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ULK4 - unc-51 like kinase 4 Gene

Also Known as FAM7C1; REC01035

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54986

About ULK4

Cytogenetic location: 3p22.1 Genomic coordinates (GRCh38): 3:41,246,599-41,962,103 (from NCBI)

This gene has 12 transcripts (splice variants), 182 orthologues and 1 paralogue. Broad expression in testis (RPKM 5.0), thyroid (RPKM 0.8) and 16 other tissues.

Summary

This gene encodes a member of the unc-51-like serine/threonine kinase (STK) family. Members of this protein family play a role in neuronal growth and endocytosis. The encoded protein is likely involved in neurite branching, neurite elongation and neuronal migration. Genome-wide association studies (GWAS) indicate an association of variations in this gene with blood pressure and hypertension. Sequence variations in this gene may also be be associated with psychiatric disorders, including schizophrenia and bipolar disorder. Pseudogenes associated with this gene have been identified and are located on chromosome 15. [provided by RefSeq, Jul 2016]

ULK4 Products (3)

mRNA	Protein	Name
NM_001322500.2	NP_001309429.1	serine/threonine-protein kinase ULK4 isoform 2
NM_001322501.2	NP_001309430.1	serine/threonine-protein kinase ULK4 isoform 3
NM_017886.4	NP_060356.2	serine/threonine-protein kinase ULK4 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within microtubule cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	24284070	GOA
acts upstream of or within protein kinase C deactivation	IMP IMP: Inferred from mutant phenotype	24284070	GOA
acts upstream of or within regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	24284070	GOA
acts upstream of or within regulation of MAPK cascade	IMP IMP: Inferred from mutant phenotype	24284070	GOA
acts upstream of or within regulation of neuron migration	IMP IMP: Inferred from mutant phenotype	24284070	GOA
acts upstream of or within regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	24284070	GOA
acts upstream of or within regulation of p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	24284070	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ULK4 Protein Structure

Pkinase

0
200
400
600
800
1000
1200
1275 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase ULK4

ULK4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ULK4	Q96C45	ANKRD40	Homo sapiens	Q6AI12	Anti Tag CoIP	28514442
Intra	ULK4	Q96C45	ANKRD40	Homo sapiens	Q6AI12	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Cardiomyopathy, Dilated, 1e	Left Ventricular Noncompaction 9 Left Ventricular Noncompaction 5 Dilated Cardiomyopathy 1e Dilated Cardiomyopathy 1s CMD1E Cdcd2 Cardiomyopathy, Dilated, 1y CMD1Y Cardiomyopathy, Dilated, 1s CMD1S Dilated Cardiomyopathy 1y Dilated Cardiomyopathy With Conduction Defect 2 Dilated Cardiomyopathy With Conduction Disorder And Arrhythmia Cardiomyopathy, Dilated, With Conduction Disorder And Arrhythmia Cardiomyopathy, Dilated, With Conduction Defect 2 Cardiomyopathy Dilated With Conduction Defect Type 2 Cardiomyopathy, Dilated 1e Cardiomyopathy, Dilated 1s Cardiomyopathy, Dilated 1y Left Ventricular Non-Compaction 5 LVNC5 Left Ventricular Non-Compaction 9 LVNC9 Cardiomyopathy, Dilated, Type 1e Cardiomyopathy, Dilated, Type 1s Cardiomyopathy, Dilated, Type 1y
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15458	ULK4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ULK4	VGNC	VGNC:48131
Mus musculus	ULK4	MGD	MGI:1921622
Rattus norvegicus	ULK4	RGD	RGD:1565726
Macaca mulatta	ULK4	VGNC	VGNC:82565
Bos taurus	ULK4	VGNC	VGNC:107015
Felis catus	ULK4	VGNC	VGNC:66817
Others	ULK4	NCBI