CEP192 - centrosomal protein 192 Gene

Also Known as PPP1R62

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55125

About CEP192

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:12,991,362-13,125,036 (from NCBI)

This gene has 14 transcripts (splice variants) and 221 orthologues. Ubiquitous expression in testis (RPKM 8.2), gall bladder (RPKM 6.1) and 25 other tissues.

Summary

Enables Phosphatase binding activity. Involved in centrosome-templated microtubule nucleation; mitotic spindle assembly; and protein localization to centrosome. Located in centriole; centrosome; and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

CEP192 Products (1)

mRNA	Protein	Name
NM_032142.4	NP_115518.3	centrosomal protein of 192 kDa

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables phosphatase binding	IDA IDA: Inferred from direct assay	19389623	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19389623	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in centrosome-templated microtubule nucleation	IMP IMP: Inferred from mutant phenotype	17980596	GOA
involved in mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	17980596	GOA
involved in protein localization to centrosome	IMP IMP: Inferred from mutant phenotype	17980596	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in centriole	IDA IDA: Inferred from direct assay	32060285	GOA
located in centrosome	IDA IDA: Inferred from direct assay	17980596	GOA
located in procentriole	IDA IDA: Inferred from direct assay	24997597	GOA
part of procentriole replication complex	IPI IPI: Inferred from physical interaction	24997597	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
centrosomal protein of 192 kDa	192 kDa centrosomal protein

CEP192 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CEP192	Q8TEP8	NUP50	Homo sapiens	Q9UKX7	Anti Bait CoIP	35709258
Intra	CEP192	Q8TEP8	PLK4	Homo sapiens	O00444	Anti Bait CoIP	24997597

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Autosomal Dominant Intellectual Developmental Disorder 40	Autosomal Dominant Non-Syndromic Intellectual Disability 40 Autosomal Dominant Mental Retardation 40 Mrd40 Mental Retardation, Autosomal Dominant 40
Alstrom Syndrome	ALMS Alström Syndrome Alss Alstrom-Hallgren Syndrome Alstroem Syndrome
Ovarian Endometrioid Stromal Sarcoma
Ovary Sarcoma	Sarcoma Of Ovary
Mulibrey Nanism	MUL Muscle-Liver-Brain-Eye Nanism Pericardial Constriction And Growth Failure Perheentupa Syndrome Mulibrey Growth Disorder Mulibrey Nanism Syndrome Pericardial Constriction With Growth Failure Nanism Mulibrey
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Primary Microcephaly	True Microcephaly Microcephaly, Primary
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02508	CEP192 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CEP192	RGD	RGD:1562797
Bos taurus	CEP192	VGNC	VGNC:27199
Felis catus	CEP192	VGNC	VGNC:82467
Mus musculus	CEP192	MGD	MGI:1918049
Canis familiaris	CEP192	VGNC	VGNC:58297
Others	CEP192	NCBI