MSL2 - MSL complex subunit 2 Gene

Also Known as MSL-2; MSL2L1; RNF184

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55167

About MSL2

Cytogenetic location: 3q22.3 Genomic coordinates (GRCh38): 3:136,148,917-136,196,335 (from NCBI)

This gene has 8 transcripts (splice variants), 263 orthologues and is associated with 1 phenotype. Ubiquitous expression in bone marrow (RPKM 16.6), lymph node (RPKM 11.8) and 25 other tissues.

Summary

Predicted to enable ubiquitin protein Ligase activity. Involved in histone H4-K16 acetylation. Part of MSL complex. [provided by Alliance of Genome Resources, Apr 2022]

MSL2 Products (2)

mRNA Protein Name
NM_001145417.2 NP_001138889.1 E3 ubiquitin-protein ligase MSL2 isoform 2
NM_018133.4 NP_060603.2 E3 ubiquitin-protein ligase MSL2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables histone H2B ubiquitin ligase activity IDA
IDA: Inferred from direct assay
21726816 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16227571 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
19033443 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
19033443 GOA
involved in protein monoubiquitination IDA
IDA: Inferred from direct assay
21726816 GOA
Cellular Component GO Annotation Evidence References Source
part of MSL complex IDA
IDA: Inferred from direct assay
20018852 GOA
is active in chromatin IDA
IDA: Inferred from direct assay
21726816 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16227571 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

E3 ubiquitin-protein ligase MSL2

  • E3 ubiquitin-protein transferase MSL2

MSL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MSL2 Q9HCI7 MSL1 Homo sapiens Q68DK7
Anti Tag CoIP
28514442
Intra
MSL2 Q9HCI7 MSL1 Homo sapiens Q68DK7
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Basilicata-Akhtar Syndrome

  • Mrxs36

  • MRXSBA

  • Mental Retardation, X-Linked, Syndromic, Basilicata-Akhtar Type

  • Mental Retardation, X-Linked, Syndromic 36

  • X-Linked Syndromic Mental Retardation 36

  • X-Linked Syndromic Mental Retardation Basilicata-Akhtar Type
Atrial Septal Defect 3

  • ASD3

  • Atrial Heart Septal Defect 3

  • Septal Defect, Atrial, Type 3
Koolen-De Vries Syndrome

  • KDVS

  • 17q21.31 Microdeletion Syndrome

  • Microdeletion 17q21.31 Syndrome

  • Chromosome 17q21.31 Deletion Syndrome

  • Koolen De Vries Syndrome

  • Kansl1-Related Intellectual Disability Syndrome

  • Chromosome 17q21.31 Microdeletion Syndrome

  • Monosomy 17q21.31

  • 17q21.31 Deletion Syndrome

  • Koolen Syndrome

  • Del(17)(Q21.31)
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08717 MSL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MSL2 VGNC VGNC:63636
Rattus norvegicus MSL2 RGD RGD:1310355
Bos taurus MSL2 VGNC VGNC:31699
Mus musculus MSL2 MGD MGI:1925103
Macaca mulatta MSL2 VGNC VGNC:74827
Canis familiaris MSL2 VGNC VGNC:43444
Others MSL2 NCBI