MSL1 - MSL complex subunit 1 Gene

Also Known as MSL-1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 339287

About MSL1

Cytogenetic location: 17q21.1 Genomic coordinates (GRCh38): 17:40,121,971-40,136,917 (from NCBI)

This gene has 11 transcripts (splice variants) and 232 orthologues. Ubiquitous expression in testis (RPKM 22.1), brain (RPKM 17.6) and 25 other tissues.

Summary

Predicted to enable chromatin binding activity. Involved in histone H4-K16 acetylation. Located in nucleoplasm. Part of MSL complex. [provided by Alliance of Genome Resources, Apr 2022]

MSL1 Products (4)

mRNA Protein Name
NM_001012241.2 NP_001012241.1 male-specific lethal 1 homolog isoform 1
NM_001365919.1 NP_001352848.1 male-specific lethal 1 homolog isoform 2
NM_001365920.1 NP_001352849.1 male-specific lethal 1 homolog isoform 3
NM_001365921.2 NP_001352850.1 male-specific lethal 1 homolog isoform 4

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16227571 GOA
enables protein-macromolecule adaptor activity IDA
IDA: Inferred from direct assay
22547026 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of DNA-templated transcription IDA
IDA: Inferred from direct assay
22547026 GOA
Cellular Component GO Annotation Evidence References Source
part of MSL complex IDA
IDA: Inferred from direct assay
20018852 GOA
located in nucleus IDA
IDA: Inferred from direct assay
15561718 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MSL1 Protein Structure

PEHE

PEHE: PEHE domain (473 - 591)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 614 a.a.
Protein Preferred Names Protein Names

male-specific lethal 1 homolog

  • MSL1-like 1

MSL1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MSL1 Q68DK7 MSL2 Homo sapiens Q9HCI7
Anti Bait CoIP
16227571
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08716 MSL1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13503 SNRPB2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21006 Oprk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus MSL1 VGNC VGNC:63635
Bos taurus MSL1 VGNC VGNC:31698
Rattus norvegicus MSL1 RGD RGD:1564778
Canis familiaris MSL1 VGNC VGNC:43443
Macaca mulatta MSL1 VGNC VGNC:74844
Mus musculus MSL1 MGD MGI:1921276
Others MSL1 NCBI