ABHD10 - abhydrolase domain containing 10, depalmitoylase Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 55347

About ABHD10

Cytogenetic location: 3q13.2 Genomic coordinates (GRCh38): 3:111,979,026-111,993,368 (from NCBI)

This gene has 5 transcripts (splice variants) and 230 orthologues. Ubiquitous expression in kidney (RPKM 20.6), thyroid (RPKM 19.7) and 25 other tissues.

Summary

This gene encodes a mitochondrially-localized enzyme that acts in liver cells as a hydrolase. The encoded protein removes glucuronide from mycophenolic acid acyl-glucuronide. There is a pseudogene for this gene on chromosome 6. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

ABHD10 Products (2)

mRNA	Protein	Name
NM_001272069.2	NP_001258998.1	palmitoyl-protein thioesterase ABHD10, mitochondrial isoform 2
NM_018394.4	NP_060864.1	palmitoyl-protein thioesterase ABHD10, mitochondrial isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IDA IDA: Inferred from direct assay	22294686	GOA
enables palmitoyl-(protein) hydrolase activity	IDA IDA: Inferred from direct assay	31740833	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	33961781	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in acyl deglucuronidation	IDA IDA: Inferred from direct assay	22294686	GOA
involved in protein depalmitoylation	IDA IDA: Inferred from direct assay	31740833	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytosol	IDA IDA: Inferred from direct assay	22294686	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	31740833	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ABHD10 Protein Structure

Abhydrolase_6

0
100
200
306 a.a.

Protein Preferred Names	Protein Names
palmitoyl-protein thioesterase ABHD10, mitochondrial	abhydrolase domain-containing protein 10, mitochondrial

ABHD10 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ABHD10	Q9NUJ1	HSPBAP1	Homo sapiens	Q96EW2	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ABHD10 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76706	ABHD10 Protein, Human (sf9, His)	Q9NUJ1-1 (T53-N306)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Hypoglycemia, Leucine-Induced	Leucine-Sensitive Hypoglycemia Of Infancy Leucine-Induced Hypoglycemia LIH Hypoglycemia Of Infancy, Leucine-Sensitive Familial Infantile Hypoglycemia Precipitated By Leucine Hypoglycemia Leucine Induced Hypoglycemia Leucine-Induced
Hypotonia-Cystinuria Syndrome	Cystinuria With Mitochondrial Disease 2p21 Microdeletion Syndrome HCS Homozygous 2p16 Deletion Syndrome, Formerly 2p21 Deletion Syndrome Del(2)(P21) Monosomy 2p21 Atypical Hypotonia-Cystinuria Syndrome Atypical Hcs
Williams-Beuren Syndrome	Williams Syndrome WBS Wms Deletion 7q11.23 Monosomy 7q11.23 Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb Fanconi Schlesinger Syndrome Beuren Syndrome Elfin Facies Syndrome Elfin Facies With Hypercalcemia Hypercalcemia-Supravalvar Aortic Stenosis Ws

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00084	ABHD10 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20131	Abhd10 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26635	Abhd10 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	ABHD10	VGNC	VGNC:56123
Macaca mulatta	ABHD10	VGNC	VGNC:69534
Mus musculus	ABHD10	MGD	MGI:2442422
Rattus norvegicus	ABHD10	RGD	RGD:1308084
Bos taurus	ABHD10	VGNC	VGNC:25488
Others	ABHD10	NCBI