PRCC - proline rich mitotic checkpoint control factor Gene

Also Known as TPRC; RCCP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5546

About PRCC

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:156,767,535-156,800,815 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and is associated with 68 phenotypes. Ubiquitous expression in brain (RPKM 14.8), spleen (RPKM 14.1) and 25 other tissues.

Summary

This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010]

PRCC Products (1)

mRNA Protein Name
NM_005973.5 NP_005964.3 proline-rich protein PRCC

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
11717438 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of cell cycle IDA
IDA: Inferred from direct assay
11717438 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
11717438 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PRCC Protein Structure

PRCC

PRCC: Mitotic checkpoint regulator, MAD2B-interacting (275 - 491)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 491 a.a.
Protein Preferred Names Protein Names

proline-rich protein PRCC

  • PRCC, proline rich mitotic checkpoint control factor

PRCC Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PRCC Q92733 HOMER3 Homo sapiens Q9NSC5
Validated Y2H
26871637
Intra
PRCC Q92733 HOMER3 Homo sapiens Q9NSC5
Y2H Array
26871637
Intra
PRCC Q92733 HOMER3 Homo sapiens Q9NSC5
Y2H Prey Pooling
26871637
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Renal Cell Carcinoma, Papillary, 1

  • Papillary Renal Cell Carcinoma

  • Hereditary Papillary Renal Cell Carcinoma

  • Papillary Renal Cell Carcinoma, Sporadic

  • Papillary Renal Cell Adenocarcinoma

  • RCCP

  • RCCP1

  • Renal Cell Carcinoma, Papillary

  • Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

  • Chromophil Carcinoma Of Kidney

  • Papillary Kidney Carcinoma

  • Sporadic Papillary Renal Cell Carcinoma

  • Chromophil Renal Cell Carcinoma

  • Papillary Renal Carcinoma, Malignant -

  • Papillary Renal Cell Carcinoma, Bilateral -

  • Papillary Renal Cell Carcinoma, Familial -

  • Papillary Renal Cell Carcinoma, Multiple -

  • Papillary Renal Cell Carcinoma, Sporadic -

  • Renal Adenocarcinoma

  • Chromophil Rcc

  • Hprcc

  • Renal Cell Carcinoma Papillary

  • Chromophilic Renal Cell Carcinoma

  • Prcc

  • Carcinoma, Renal Cell, Papillary, Type 1

  • Type 1 Papillary Renal Cell Carcinoma

  • Renal Cell Carcinoma

  • Hereditary Papillary Renal Carcinoma
Renal Cell Carcinoma, Xp11-Associated

  • RCCX1

  • Mit Family Translocation Renal Cell Carcinoma

  • Renal Cell Carcinoma, Papillary, 1

  • Carcinoma Associated With Mitf/Tfe Translocation

  • Translocation Renal Cell Carcinoma

  • Renal Cell Carcinoma Xp11-Associated

  • Renal Cell Carcinoma Papillary 1

  • Carcinoma, Renal Cell, Xp11-Associated
Late Yaws

  • Yaws Gummata And Ulcers

  • Gummata And Ulcers Due To Yaws

  • Gummata Of Yaws

  • Gummatous Frambeside

  • Multiple Papillomata Due To Yaws And Wet Crab Yaws

  • Nodular Late Yaws

  • Ulcers Of Yaws
Epithelial Predominant Wilms' Tumor

  • Epithelial Predominant Kidney Adenosarcoma

  • Epithelial Predominant Renal Wilms Tumor

  • Epithelial Predominant Renal Wilms Tumour

  • Epithelial Predominant Wilms' Tumour
Childhood Kidney Cell Carcinoma

  • Pediatric Renal Cell Carcinoma

  • Childhood Renal Cell Carcinoma
Metanephric Adenoma
Renal Adenoma

  • Renal Cell Adenoma
Alveolar Soft Part Sarcoma

  • ASPS

  • Alveolar Soft-Part Sarcoma

  • Sarcoma, Alveolar Soft Part

  • Alveolar Soft Tissue Sarcoma

  • Sarcoma Alveolar Soft Part

  • Adult Alveolar Soft-Part Sarcoma

  • Childhood Alveolar Soft-Part Sarcoma
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Nephrogenic Adenofibroma

  • Metanephric Adenofibroma
Collecting Duct Carcinoma

  • Kidney Medullary Carcinoma

  • Renal Medullary Carcinoma

  • Bdc

  • Bellini Carcinoma

  • Bellini Duct Carcinoma

  • Cdc

  • Collecting Duct Carcinoma Of The Kidney

  • Renal Cell Adenocarcinoma

  • Carcinoma Of Renal Collecting Duct

  • Renal Carcinoma, Collecting Duct Type

  • Renal Cell Carcinoma

  • Bellini'S Duct Carcinoma

  • Renal Collecting Duct Carcinoma

  • Adenocarcinoma Of Kidney
Perivascular Epithelioid Cell Tumor

  • Pecoma

  • Perivascular Epithelioid Cell Neoplasms

  • Neoplasm With Perivascular Epithelioid Cell Differentiation
Hawkinsinuria

  • 4-Alpha-Hydroxyphenylpyruvate Hydroxylase Deficiency

  • 4-Hppd Deficiency

  • 4-Hydroxyphenylpyruvic Acid Dioxygenase Deficiency

  • HWKS

  • HAWK
Bejel

  • Njovera

  • Dichuchwa

  • Nonvenereal Endemic Syphilis

  • Endemic Syphilis

  • Frenga

  • Nonvenereal Syphilis

  • Treponemal Infections

  • Non-Venereal Endemic Syphilis

  • Siti

  • Skerljevo

  • Belesh
Yaws

  • Frambesia

  • Frambesia Tropica

  • Bouba

  • Frambosie

  • Polypapilloma Tropicum

  • Thymosis

  • Endemic Treponematoses

  • Treponema Pertenue Infection

  • Pian

  • Framboesia

  • Framboesia Tropica

  • Castellani

  • Infection By Treponema Pertenue

  • Parangi

  • Framboesioma

  • Chancre Of Yaws

  • Primary Framboesia

  • Initial Lesions Of Yaws

  • Mother Yaw

  • Initial Framboesia
Kidney Benign Neoplasm

  • Renal And Ureteral Tumor

  • Benign Kidney Neoplasm
Chromophobe Renal Cell Carcinoma

  • Chromophobe Adenocarcinoma

  • Chromophobe Carcinoma Of Kidney

  • Kidney Chromophobe

  • Renal Cell Carcinoma, Chromophobe Cell

  • Crcc

  • Chrcc

  • Chromophobe Renal Cell Adenocarcinoma

  • Chromophobe Renal Carcinoma

  • Chromophobe Carcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11056 PRCC Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PRCC RGD RGD:1309037
Felis catus PRCC VGNC VGNC:69031
Canis familiaris PRCC VGNC VGNC:56084
Macaca mulatta PRCC VGNC VGNC:100046
Mus musculus PRCC MGD MGI:2137738
Bos taurus PRCC VGNC VGNC:56085
Others PRCC NCBI