RIOK2 - RIO kinase 2 Gene

Also Known as RIO2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 55781

About RIOK2

Cytogenetic location: 5q15 Genomic coordinates (GRCh38): 5:97,160,867-97,183,247 (from NCBI)

This gene has 7 transcripts (splice variants), 198 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 5.0), ovary (RPKM 4.8) and 25 other tissues.

Summary

Predicted to enable protein kinase activity. Involved in several processes, including positive regulation of rRNA processing; positive regulation of ribosomal small subunit export from nucleus; and regulation of mitotic metaphase/anaphase transition. Located in cytoplasm. Part of preribosome, small subunit precursor. [provided by Alliance of Genome Resources, Apr 2022]

RIOK2 Products (2)

mRNA Protein Name
NM_001159749.2 NP_001153221.1 serine/threonine-protein kinase RIO2 isoform 2
NM_018343.3 NP_060813.2 serine/threonine-protein kinase RIO2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21880710 GOA
Biological Process GO Annotation Evidence References Source
involved in maturation of SSU-rRNA IMP
IMP: Inferred from mutant phenotype
19564402 GOA
involved in positive regulation of rRNA processing IDA
IDA: Inferred from direct assay
19564402 GOA
involved in positive regulation of ribosomal small subunit export from nucleus IMP
IMP: Inferred from mutant phenotype
19564402 GOA
involved in protein autophosphorylation IMP
IMP: Inferred from mutant phenotype
21880710 GOA
involved in regulation of mitotic metaphase/anaphase transition IMP
IMP: Inferred from mutant phenotype
21880710 GOA
involved in ribosomal small subunit biogenesis IMP
IMP: Inferred from mutant phenotype
19564402 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IMP
IMP: Inferred from mutant phenotype
19564402 GOA
part of preribosome, small subunit precursor IDA
IDA: Inferred from direct assay
19564402 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RIOK2 Protein Structure

Rio2_N

Rio2_N: Rio2, N-terminal (9 - 91)

RIO1

RIO1: RIO1 family (108 - 279)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 552 a.a.
Protein Preferred Names Protein Names

serine/threonine-protein kinase RIO2

Related Diseases

Diseases Alias
Cecum Carcinoma

  • Cecum Cancer

  • Caecum Carcinoma

  • Carcinoma Of Cecum

  • Cecal Cancer

  • Malignant Neoplasm Of Caecum

  • Malignant Tumor Of The Cecum
Cecum Adenocarcinoma

  • Cecal Adenocarcinoma

  • Adenocarcinoma Of Cecum
Diamond-Blackfan Anemia

  • Congenital Pure Red Cell Aplasia

  • Aase Syndrome

  • Erythrogenesis Imperfecta

  • Anemia, Diamond-Blackfan

  • Congenital Hypoplastic Anemia

  • Aase-Smith Ii Syndrome

  • Bds

  • Blackfan-Diamond Anemia

  • Congenital Prca

  • Congenital Hypoplastic Anemia, Blackfan-Diamond Type

  • Dba

  • Blackfan - Diamond Syndrome

  • Chronic Constitutional Pure Red Cell Anaemia

  • Anemia Diamond Blackfan Type

  • Anemia Congenital Erythroid Hypoplastic

  • Aregenerative Anemia Chronic Congenital

  • Blackfan Diamond Syndrome

  • Red Cell Aplasia, Pure Hereditary

  • Aase-Smith Syndrome Ii

  • Bda

  • Blackfan Diamond Anemia

  • Blackfan-Diamond Disease

  • Blackfan-Diamond Syndrome

  • Chronic Congenital Agenerative Anemia

  • Congenital Erythroid Hypoplastic Anemia

  • Congenital Hypoplastic Anemia Of Blackfan And Diamond

  • Congenital Pure Red Cell Anemia

  • Hypoplastic Congenital Anemia

  • Inherited Erythroblastopenia

  • Pure Hereditary Red Cell Aplasia

  • Anemia, Hypoplastic, Congenital

  • Anemia Hypoplastic Congenital

  • Fanconi Anemia

  • Constitutional Aplastic Anemia

  • Diamond-Blackfan Anemia 1

  • Aase Smith Syndrome 2

  • Congenital Red Cell Aplasia

  • Red Cell Aplasia Of Infants

  • Pure Red Cell Aplasia Of Infants

  • Congenital Red Cell Aplastic Anaemia

  • Congenital Pure Red Cell Anaemia

  • Congenital Erythroid Hypoplasia

  • Pearson Marrow-Pancreas Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-147655 CQ211 Inhibitor 99.90% Unkown
HY-112158 NSC139021 99.77% Unkown
HY-139893 ERGi-USU-6 mesylate Inhibitor 95.0% Unkown
HY-170574 CQ627 Degrader 98.93% Unkown
HY-156792 RIOK2-IN-1 Inhibitor / Unkown
HY-175733 CQ3196 Inhibitor / Unkown
HY-156465 RIOK2-IN-2 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta RIOK2 VGNC VGNC:76774
Bos taurus RIOK2 VGNC VGNC:50056
Felis catus RIOK2 VGNC VGNC:97605
Mus musculus RIOK2 MGD MGI:1914295
Rattus norvegicus RIOK2 RGD RGD:1311588
Canis familiaris RIOK2 VGNC VGNC:53201
Others RIOK2 NCBI