PRRG1 - proline rich and Gla domain 1 Gene
Also Known as PRGP1
Species: Homo sapiens
About PRRG1
This gene has 9 transcripts (splice variants), 203 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 6.8), gall bladder (RPKM 4.8) and 23 other tissues.
Summary
This gene encodes a vitamin K-dependent, gamma-carboxyglutamic acid (Gla)-containing, single-pass transmembrane protein. This protein contains a Gla domain at the N-terminus, preceded by a propeptide sequence required for post-translational gamma-carboxylation of specific glutamic acid residues by a vitamin K-dependent gamma-carboxylase. The C-terminus is proline-rich containing PPXY and PXXP motifs found in a variety of signaling and cytoskeletal proteins. This gene is highly expressed in the spinal cord. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]
PRRG1 Products (5)
| mRNA | Protein | Name |
|---|---|---|
| NM_000950.3 | NP_000941.1 | transmembrane gamma-carboxyglutamic acid protein 1 isoform 1 precursor |
| NM_001142395.2 | NP_001135867.1 | transmembrane gamma-carboxyglutamic acid protein 1 isoform 1 precursor |
| NM_001173486.2 | NP_001166957.1 | transmembrane gamma-carboxyglutamic acid protein 1 isoform 2 precursor |
| NM_001173489.2 | NP_001166960.1 | transmembrane gamma-carboxyglutamic acid protein 1 isoform 1 precursor |
| NM_001173490.2 | NP_001166961.1 | transmembrane gamma-carboxyglutamic acid protein 1 isoform 1 precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
PRRG1 Protein Structure
Gla: Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain (25 - 65)
- 0
- 100
- 200
- 218 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
transmembrane gamma-carboxyglutamic acid protein 1 |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Vitamin K-Dependent Clotting Factors, Combined Deficiency Of, 1 |
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| Meckel Syndrome, Type 7 |
|
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| Hereditary Combined Deficiency Of Vitamin K-Dependent Clotting Factors |
|
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| Vitamin K Deficiency Bleeding |
|
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| Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Felis catus | PRRG1 | VGNC | VGNC:69084 |
| Canis familiaris | PRRG1 | VGNC | VGNC:45055 |
| Rattus norvegicus | PRRG1 | RGD | RGD:1561320 |
| Bos taurus | PRRG1 | VGNC | VGNC:106878 |
| Mus musculus | PRRG1 | MGD | MGI:1917364 |
| Others | PRRG1 | NCBI |