PRSS8 - serine protease 8 Gene

Homo sapiens

Also known as CAP1; PROSTASIN

Gene ID: 5652 | Gene type: protein coding

About PRSS8

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:31,131,433-31,135,727 (from NCBI)

This gene has 6 transcripts (splice variants) and 105 orthologues. Broad expression in small intestine (RPKM 73.7), colon (RPKM 73.6) and 14 other tissues.

Summary

This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate LIGHT and heavy chains that associate via a disulfide bond to form the heterodimeric Enzyme. This Enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial Sodium Channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]

PRSS8 Products(1)

mRNA	Protein	Name
NM_002773.5	NP_002764.1	prostasin preproprotein

PRSS8 Protein Structure

Trypsin

0
100
200
300
343 a.a.

Protein Preferred Names

Protein Names

prostasin

channel-activating protease 1

Recombinant PRSS8 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77153	Prostasin/PRSS8 Protein, Human (HEK293, His)	Q16651 (A30-R322)	≥95%

Related Diseases

Diseases

Alias

Pseudohypoaldosteronism

Ichthyosis, Congenital, Autosomal Recessive 11

Autosomal Recessive Congenital Ichthyosis 11	Ichthyosis With Hypotrichosis, Autosomal Recessive
Arih	Ichthyosis And Follicular Atrophoderma With Hypotrichosis And Hypohidrosis
Autosomal Recessive Ichthyosis With Hypotrichosis	ARCI11
Ifah	Hypotrichosis-Congenital Ichthyosis Syndrome
Ichthyosis-Follicular Atrophoderma-Hypotrichosis Syndrome	Ichthyosis-Follicular Atrophoderma-Hypotrichosis-Hypohidrosis Syndrome
Ichthyosis-Hypotrichosis Syndrome	Ifah Syndrome
Ihs

Conn'S Syndrome

Cushing Syndrome	Hyperaldosteronism
Primary Hyperaldosteronism	Hypercortisolism
Primary Aldosteronism	Cushing'S Syndrome
Adrenal Gland Hyperfunction	Conn Syndrome
Hyperadrenalism	Ectopic Acth Syndrome
Hyperadrenocorticism	Cushing Disease
Cushing'S Disease	Adrenal Cortex Adenoma
Corticotroph Pituitary Adenoma	Pituitary Corticotroph Micro-Adenoma
Pituitary-Dependent Cushing Syndrome	Pituitary Acth Hypersecretion
Acth Syndrome, Ectopic	Acth-Secreting Pituitary Adenoma
Adrenal Hyperfunction Resulting From Pituitary Acth Excess	Ectopic Adrenocorticotropic Hormone Syndrome
Nodular Primary Adrenocortical Dysplasia	Pituitary Dependent Cushing Syndrome
Pituitary Cushing Syndrome	Pituitary-Dependant Cushing Syndrome
Pituitary-Dependant Hypercortisolism	Pituitary-Dependant Hypercortisolism Disorder
Aldosteronism Primary	Acth Syndrome Ectopic
Adrenal Cushing'S Syndrome	Adrenal Cortical Adenoma
Cushing Syndrome Nos	Cortisol Hypersecretion
Corticoadrenal Hypersecretion	Cushing Syndrome Secondary To Ectopic Acth-Secretion
Ectopic Cushing Syndrome	Hypercortisolism Due To Nonpituitary Tumour
Ectopic Acth - [Adrenocorticotropic Hormone] Secretion	Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome
Idiopathic Aldosteronism	Aldosteronism
Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia	Primary Aldosteronism Due To Adrenal Hyperplasia

Hypotrichosis

Ichthyosis

Ichthyoses	Non-Syndromic Ichthyosis
Congenital Ichthyosis

Diarrhea 5, With Tufting Enteropathy, Congenital

Congenital Diarrhea 5 With Tufting Enteropathy	Congenital Tufting Enteropathy
DIAR5	Cte
Intestinal Epithelial Cell Dysplasia	Tufting Enteropathy
Ied	Intestinal Epithelial Dysplasia
Enteropathy, Congenital Tufting	Congenital Diarrhoea 5 With Tufting Enteropathy
Congenital Familial Intractable Diarrhea With Epithelial Or Epithelium Abnormalities	Congenital Familial Intractable Diarrhoea With Epithelial Or Epithelium Abnormalities
Congenital Enteropathy	Congenital Familial Intractable Diarrhea With Enterocytes Assembly Abnormalities
Non-Syndromic Congenital Tufting Enteropathy	Diarrhea, Type 5, With Tufting Enteropathy, Congenital
Intestinal Intraepithelial Neoplasia

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Liddle Syndrome 1

Liddle Syndrome	Pseudoaldosteronism
Liddle'S Syndrome	LIDLS1
Lidls	Pseudohyperaldosteronism
Pseudoprimary Hyperaldosteronism	Pseudohyperaldosteronism Type 1
Liddles Syndrome

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

Autosomal Recessive Congenital Ichthyosis

Lamellar Ichthyosis	Congenital Ichthyosiform Erythroderma
Li	Congenital Nonbullous Ichthyosiform Erythroderma
Arci	Congenital Lamellar Ichthyosis
Nonbullous Congenital Ichthyosiform Erythroderma	Cie
Congenital Non-Bullous Ichthyosiform Erythroderma	Erythrodermic Ichthyosis
Nbcie	Ncie
Non-Bullous Congenital Ichthyosiform Erythroderma	Collodion Baby
Ichthyosis, Lamellar	Non Bullous Congenital Ichthyosiform Erythroderma
Ichthyosiform Erythroderma, Brocq Congenital, Nonbullous Form	Ichthyosiform Erythroderma, Congenital, Nonbullous, 1
Collodion Baby Syndrome	Ichthyoses, Lamellar
Nbie	Nonbullous Ichthyosiform Erythroderma
Classic Lamellar Ichthyosis	Ichthyosiform Erythroderma Nonbullous Congenital
Ichthyosiform Erythroderma Congenital	Ichthyosis, Congenital, Autosomal Recessive
Ichthyosiform Erythroderma, Congenital	Collodion Fetus
Non-Bullous Ichthyosiform Erythroderma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11259	PRSS8 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PRSS8	RGD	RGD:619973
Macaca mulatta	PRSS8	VGNC	VGNC:76433
Mus musculus	PRSS8	MGD	MGI:1923810
Canis familiaris	PRSS8	VGNC	VGNC:45074
Felis catus	PRSS8	VGNC	VGNC:69092
Bos taurus	PRSS8	VGNC	VGNC:33426
Others	PRSS8	NCBI

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