BDH2 - 3-hydroxybutyrate dehydrogenase 2 Gene

Also Known as DHRS6; EFA6R; SDR15C1; UCPA-OR; UNQ6308; PRO20933

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56898

About BDH2

This gene has 9 transcripts (splice variants) and 201 orthologues. Broad expression in kidney (RPKM 50.7), duodenum (RPKM 25.0) and 23 other tissues.

Summary

Enables 3-hydroxybutyrate dehydrogenase activity and NAD binding activity. Involved in epithelial cell differentiation and fatty acid beta-oxidation. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

BDH2 Products (1)

mRNA Protein Name
NM_020139.4 NP_064524.3 dehydrogenase/reductase SDR family member 6

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables 3-hydroxybutyrate dehydrogenase activity IDA
IDA: Inferred from direct assay
16380372 GOA
enables NAD binding IDA
IDA: Inferred from direct assay
16380372 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in epithelial cell differentiation IDA
IDA: Inferred from direct assay
21492153 GOA
involved in fatty acid beta-oxidation IDA
IDA: Inferred from direct assay
16380372 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16380372 GOA
NOT located in mitochondrion IDA
IDA: Inferred from direct assay
16380372 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BDH2 Protein Structure

adh_short_C2

adh_short_C2: Enoyl-(Acyl carrier protein) reductase (15 - 243)

  • 0
  • 100
  • 200
  • 245 a.a.
Protein Preferred Names Protein Names

dehydrogenase/reductase SDR family member 6

3-hydroxybutyrate dehydrogenase type 2

  • (R)-beta-hydroxybutyrate dehydrogenase

Recombinant BDH2 Proteins

Cat. No. Product Name Accession Purity
HY-P7659 BDH2 Protein, Human (His) AAH01953.1 (M1-L245) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Alpha-Methylacetoacetic Aciduria

  • Beta-Ketothiolase Deficiency

  • 3-Ketothiolase Deficiency

  • 3-Oxothiolase Deficiency

  • Mitochondrial Acetoacetyl-Coa Thiolase Deficiency

  • Alpha-Methylacetoaceticaciduria

  • Mat Deficiency

  • T2 Deficiency

  • 2-Methyl-3-Hydroxybutyricacidemia

  • Beta Ketothiolase Deficiency

  • Pseudo-Zellweger Syndrome

  • 2-Methyl-3-Hydroxybutyric Acidemia

  • 3-Ktd Deficiency

  • Peroxisomal Thiolase Deficiency

  • 2-Methylacetoacetyl-Coenzyme A Thiolase Deficiency

  • 3-Alpha-Oxothiolase Deficiency

  • Methylacetoacetyl-Coenzyme A Thiolase Deficiency

  • Mitochondrial 2-Methylacetoacetyl-Coa Thiolase Deficiency - Potassium Stimulated

  • Β-Ketothiolase Deficiency

  • Alpha Methylacetoacetic Aciduria

  • Alpha-Methyl-Acetoacetyl-Coa Thiolase Deficiency

  • Mitochondrial Acetoacetyl-Coenzyme A Thiolase Deficiency

  • 3KTD

  • Aciduria, Alpha-Methylacetoacetic

  • Deficiency Of Acetyl-Coa Acetyltransferase

  • Deficiency Of Acetyl-Coa Acyltransferase

  • Hepatic Methionine Adenosyltransferase Deficiency

  • Bifunctional Peroxisomal Enzyme Deficiency
Alcohol Dependence

  • Alcoholism

  • Alcohol Dependence, Susceptibility To

  • Alcohol Dependence, Protection Against

  • Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

  • Alcoholism, Susceptibility To

  • Alcoholic Intoxication, Chronic

  • Pharyngeal Neoplasms

  • Chronic Alcoholism

  • Dipsomania

  • Alcohol Addiction

  • Ethanol Dependence

  • Chronic Ethanolism

  • Chronic Alcoholic Disease Nos

  • Alcoholic Disease Nos

  • Alcoholic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS01453 BDH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19878 Bdh2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26377 Bdh2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus BDH2 VGNC VGNC:26458
Canis familiaris BDH2 VGNC VGNC:38423
Felis catus BDH2 VGNC VGNC:60097
Rattus norvegicus BDH2 RGD RGD:1309898
Mus musculus BDH2 MGD MGI:1917022
Macaca mulatta BDH2 VGNC VGNC:70161
Others BDH2 NCBI