NCLN - nicalin Gene

Homo sapiens

Also known as NET59

Gene ID: 56926 | Gene type: protein coding

About NCLN

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,185,930-3,209,575 (from NCBI)

This gene has 8 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in colon (RPKM 14.1), duodenum (RPKM 12.9) and 25 other tissues.

Summary

Enables ribosome binding activity. Involved in protein stabilization; regulation of protein complex stability; and regulation of protein-containing complex assembly. Located in endoplasmic reticulum membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

NCLN Products(2)

mRNA	Protein	Name
NM_001321463.2	NP_001308392.1	nicalin isoform 2 precursor
NM_020170.4	NP_064555.2	nicalin isoform 1 precursor

NCLN Protein Structure

Peptidase_M28

0
100
200
300
400
500
563 a.a.

Protein Preferred Names

Protein Names

nicalin

nicalin homolog

Related Diseases

Diseases

Alias

Hirschsprung Disease 1

Hirschsprung Disease	Aganglionic Megacolon
Hscr	Hirschsprung'S Disease
Congenital Megacolon	Congenital Intestinal Aganglionosis
Colonic Aganglionosis	Hirschsprung Disease, Susceptibility To, 1
Hirschsprung Disease, Protection Against	HSCR1
Mgc	Pelvirectal Achalasia
Total Intestinal Aganglionosis	Megacolon, Aganglionic
Macrocolon	Hscr 1
Hirschsprung Disease Type 1	Hirschsprung Disease, Type 1
Congenital Dilatation Of Colon	Aganglionosis
Congenital Aganglionic Megacolon	Aganglionosis Of Colon
Bowel Aganglionosis	Colon Aganglionosis
Hirschsprung Megacolon

Lissencephaly 4

LIS4	Lissencephaly 4 With Microcephaly
Microlissencephaly	Lissencephaly, Type 4

Janus Kinase-3 Deficiency

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome	Berdon Syndrome
MMIHS	Megacystis Microcolon Intestinal Hypoperistalsis Syndrome
Megacystis, Microcolon, Hypoperistalsis Syndrome	Visceral Myopathy
Mmih Syndrome	Megacystis-Microcolon-Intestinal Hypoperistalsis-Hydronephrosis Syndrome
MMIHS1	Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome, Mmih
Mmhs

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09087	NCLN Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NCLN	RGD	RGD:1309355
Felis catus	NCLN	VGNC	VGNC:80632
Mus musculus	NCLN	MGD	MGI:1926081
Bos taurus	NCLN	VGNC	VGNC:31919
Macaca mulatta	NCLN	VGNC	VGNC:75032
Canis familiaris	NCLN	VGNC	VGNC:43658