NCLN - nicalin Gene

Also Known as NET59

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 56926

About NCLN

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:3,185,930-3,209,575 (from NCBI)

This gene has 8 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in colon (RPKM 14.1), duodenum (RPKM 12.9) and 25 other tissues.

Summary

Enables ribosome binding activity. Involved in protein stabilization; regulation of protein complex stability; and regulation of protein-containing complex assembly. Located in endoplasmic reticulum membrane. Part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]

NCLN Products (2)

mRNA Protein Name
NM_001321463.2 NP_001308392.1 nicalin isoform 2 precursor
NM_020170.4 NP_064555.2 nicalin isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
17261586 GOA
enables ribosome binding IDA
IDA: Inferred from direct assay
32820719 GOA
Biological Process GO Annotation Evidence References Source
involved in multi-pass transmembrane protein insertion into ER membrane IDA
IDA: Inferred from direct assay
36261522 GOA
involved in protein stabilization IMP
IMP: Inferred from mutant phenotype
20538592 GOA
involved in regulation of protein complex stability IDA
IDA: Inferred from direct assay
20538592 GOA
involved in regulation of protein-containing complex assembly IDA
IDA: Inferred from direct assay
20538592 GOA
Cellular Component GO Annotation Evidence References Source
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
20538592 GOA
part of multi-pass translocon complex IDA
IDA: Inferred from direct assay
36261522 GOA
part of protein-containing complex IDA
IDA: Inferred from direct assay
20538592 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NCLN Protein Structure

Peptidase_M28

Peptidase_M28: Peptidase family M28 (218 - 383)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 563 a.a.
Protein Preferred Names Protein Names

nicalin

  • nicalin homolog

NCLN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
NCLN Q969V3 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
NCLN Q969V3 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
NCLN Q969V3 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Hirschsprung Disease 1

  • Hirschsprung Disease

  • Aganglionic Megacolon

  • Hscr

  • Hirschsprung'S Disease

  • Congenital Megacolon

  • Congenital Intestinal Aganglionosis

  • Colonic Aganglionosis

  • Hirschsprung Disease, Susceptibility To, 1

  • Hirschsprung Disease, Protection Against

  • HSCR1

  • Mgc

  • Pelvirectal Achalasia

  • Total Intestinal Aganglionosis

  • Megacolon, Aganglionic

  • Macrocolon

  • Hscr 1

  • Hirschsprung Disease Type 1

  • Hirschsprung Disease, Type 1

  • Congenital Dilatation Of Colon

  • Aganglionosis

  • Congenital Aganglionic Megacolon

  • Aganglionosis Of Colon

  • Bowel Aganglionosis

  • Colon Aganglionosis

  • Hirschsprung Megacolon
Lissencephaly 4

  • LIS4

  • Lissencephaly 4 With Microcephaly

  • Microlissencephaly

  • Lissencephaly, Type 4
Janus Kinase-3 Deficiency
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1

  • Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome

  • Berdon Syndrome

  • MMIHS

  • Megacystis Microcolon Intestinal Hypoperistalsis Syndrome

  • Megacystis, Microcolon, Hypoperistalsis Syndrome

  • Visceral Myopathy

  • Mmih Syndrome

  • Megacystis-Microcolon-Intestinal Hypoperistalsis-Hydronephrosis Syndrome

  • MMIHS1

  • Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome, Mmih

  • Mmhs
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS09087 NCLN Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus NCLN RGD RGD:1309355
Felis catus NCLN VGNC VGNC:80632
Mus musculus NCLN MGD MGI:1926081
Bos taurus NCLN VGNC VGNC:31919
Macaca mulatta NCLN VGNC VGNC:75032
Canis familiaris NCLN VGNC VGNC:43658
Others NCLN NCBI