PYGB - glycogen phosphorylase B Gene

Homo sapiens

Also known as GPBB

Gene ID: 5834 | Gene type: protein coding

About PYGB

Cytogenetic location: 20p11.21 Genomic coordinates (GRCh38): 20:25,248,085-25,298,012 (from NCBI)

This gene has 3 transcripts (splice variants), 176 orthologues and 2 paralogues. Broad expression in colon (RPKM 67.8), heart (RPKM 66.8) and 23 other tissues.

Summary

The protein encoded by this gene is a glycogen phosphorylase found predominantly in the brain. The encoded protein forms homodimers which can associate into homotetramers, the enzymatically active form of glycogen phosphorylase. The activity of this Enzyme is positively regulated by AMP and negatively regulated by ATP, ADP, and glucose-6-phosphate. This Enzyme catalyzes the rate-determining step in glycogen degradation. [provided by RefSeq, Jul 2008]

PYGB Products(1)

mRNA	Protein	Name
NM_002862.4	NP_002853.2	glycogen phosphorylase, brain form

PYGB Protein Structure

Phosphorylase

0
200
400
600
843 a.a.

Protein Preferred Names

Protein Names

glycogen phosphorylase, brain form

phosphorylase, glycogen

Related Diseases

Diseases

Alias

Glycogen Storage Disease Vi

Glycogen Storage Disease Type Vi	Hers Disease
GSD6	Gsd Vi
Hepatic Glycogen Phosphorylase Deficiency	Phosphorylase Deficiency Glycogen-Storage Disease Of Liver
Hers' Disease	Glycogen Storage Disease Type 6
Glycogen Storage Disease 6	Gsd Type Vi
Glycogenosis Type Vi	Glycogen Storage Disease, Type Vi
Hepatophosphorylase Deficiency Glycogenosis	Liver Phosphorylase Deficiency Syndrome
Glycogen Storage Disease Due To Liver Glycogen Phosphorylase Deficiency	Gsd Due To Liver Glycogen Phosphorylase Deficiency
Gsd Type 6	Glycogenosis Due To Liver Glycogen Phosphorylase Deficiency
Glycogenosis Type 6	Hepatic Phosphorylase Deficiency
Liver Glycogen Phosphorylase Deficiency	Her
Glycogen Storage Disease Vib	Gsd-Vi
Liver Phosphorylase Deficiency	Storage Disease, Glycogen, Type Vi

Glycogen Storage Disease Viii

Glycogen Storage Disease Type Viii	Glycogenosis Type Viii
Glycogen Storage Disease 8	Hepatic Glycogen Phosphorylase Kinase Deficiency
Glycogenosis Type 8	Hepatic Phosphorylase Kinase Deficiency
Pykl	Phosphorylase Kinase Deficiency Of Liver
Glycogen Storage Disease, Type Ix

Glycogen Storage Disease V

Mcardle Disease	Myophosphorylase Deficiency
Glycogen Storage Disease Type V	Muscle Glycogen Phosphorylase Deficiency
Pygm Deficiency	Gsd V
Glycogen Storage Disease, Type V	Glycogenosis Type V
Glycogen Storage Disease Type 5	GSD5
Pygmy	Mcardle'S Disease
Mcardle Type Glycogen Storage Disease	Gsd Type V
Pygmy, African	Gsdv
Gsd 5	Glycogenosis 5
Mcardle Syndrome	Muscle Phosphorylase Deficiency
Glycogen Storage Disease Due To Muscle Glycogen Phosphorylase Deficiency	Gsd Due To Muscle Glycogen Phosphorylase Deficiency
Gsd Type 5	Glycogenosis Due To Muscle Glycogen Phosphorylase Deficiency
Glycogenosis Type 5	Glycogen Storage Disease 5
Gsd-V	Mcardles Disease
Storage Disease, Glycogen, Type V

Glycogen Storage Disease Ixa

Glycogen Storage Disease Type 9a	Glycogen Storage Disease Type Ixa
Glycogenosis Type 9a	Glycogenosis Type Ixa
Gsd Type 9a	Gsd Type Ixa
Gsd9a

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Myoclonic Epilepsy Of Lafora

Lafora Disease	Epilepsy, Progressive Myoclonic 2b
EPM2	Melf
Epilepsy, Progressive Myoclonic 2a	Epm2a
Lafora'S Disease	Lafora Body Disease
Lbd	Epilepsy, Progressive Myoclonic, 2a
Lafora Progressive Myoclonic Epilepsy	Epilepsy Progressive Myoclonic 2
Lafora Body Disorder	Pme Type 2
Progressive Myoclonic Epilepsy Type 2	Progressive Myoclonus Epilepsy Type 2
Epilepsy, Progressive Myoclonic 2	Epm2b
Ld	Progressive Myoclonic Epilepsy 2
Progressive Myoclonic Epilepsy 2a	Progressive Myoclonic Epilepsy 2b
Progressive Myoclonic Epilepsy Lafora Type	Epilepsy, Myoclonic, Of Lafora

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11488	PYGB Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PYGB	MGD	MGI:97828
Rattus norvegicus	PYGB	RGD	RGD:3460
Felis catus	PYGB	VGNC	VGNC:69192
Bos taurus	PYGB	VGNC	VGNC:57019
Canis familiaris	PYGB	VGNC	VGNC:52899
Macaca mulatta	PYGB	VGNC	VGNC:76631