PPP1R3B - protein phosphatase 1 regulatory subunit 3B Gene

Also Known as GL; PTG; PPP1R4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79660

About PPP1R3B

Cytogenetic location: 8p23.1 Genomic coordinates (GRCh38): 8:9,136,255-9,151,539 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 210 orthologues and 6 paralogues. Broad expression in liver (RPKM 50.1), heart (RPKM 12.4) and 22 other tissues.

Summary

This gene encodes the catalytic subunit of the serine/theonine Phosphatase, protein phosphatase-1. The encoded protein is expressed in liver and skeletal muscle tissue and may be involved in regulating glycogen synthesis in these tissues. This gene may be a involved in type 2 diabetes and maturity-onset diabetes of the young. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Jan 2011]

PPP1R3B Products (2)

mRNA Protein Name
NM_001201329.2 NP_001188258.1 protein phosphatase 1 regulatory subunit 3B
NM_024607.4 NP_078883.2 protein phosphatase 1 regulatory subunit 3B

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
15231748 GOA
Biological Process GO Annotation Evidence References Source
involved in negative regulation of glycogen catabolic process IDA
IDA: Inferred from direct assay
22225877 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R3B Protein Structure

CBM_21

CBM_21: Carbohydrate/starch-binding module (family 21) (128 - 232)

  • 0
  • 100
  • 200
  • 285 a.a.
Protein Preferred Names Protein Names

protein phosphatase 1 regulatory subunit 3B

  • PP1 subunit R4

PPP1R3B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PPP1R3B Q86XI6 PPP1CC Homo sapiens P36873
Anti Tag CoIP
33961781
Intra
PPP1R3B Q86XI6 PPP1CA Homo sapiens P62136
Y2H
15231748
Intra
PPP1R3B Q86XI6 PPP1CA Homo sapiens P62136
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Glycogen Storage Disease Vi

  • Glycogen Storage Disease Type Vi

  • Hers Disease

  • GSD6

  • Gsd Vi

  • Hepatic Glycogen Phosphorylase Deficiency

  • Phosphorylase Deficiency Glycogen-Storage Disease Of Liver

  • Hers' Disease

  • Glycogen Storage Disease Type 6

  • Glycogen Storage Disease 6

  • Gsd Type Vi

  • Glycogenosis Type Vi

  • Glycogen Storage Disease, Type Vi

  • Hepatophosphorylase Deficiency Glycogenosis

  • Liver Phosphorylase Deficiency Syndrome

  • Glycogen Storage Disease Due To Liver Glycogen Phosphorylase Deficiency

  • Gsd Due To Liver Glycogen Phosphorylase Deficiency

  • Gsd Type 6

  • Glycogenosis Due To Liver Glycogen Phosphorylase Deficiency

  • Glycogenosis Type 6

  • Hepatic Phosphorylase Deficiency

  • Liver Glycogen Phosphorylase Deficiency

  • Her

  • Glycogen Storage Disease Vib

  • Gsd-Vi

  • Liver Phosphorylase Deficiency

  • Storage Disease, Glycogen, Type Vi
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10999 PPP1R3B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PPP1R3B MGD MGI:2177268
Rattus norvegicus PPP1R3B RGD RGD:621600
Macaca mulatta PPP1R3B VGNC VGNC:104472
Felis catus PPP1R3B VGNC VGNC:107422
Canis familiaris PPP1R3B VGNC VGNC:44897
Bos taurus PPP1R3B VGNC VGNC:33243
Others PPP1R3B NCBI