country

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

RPLP1 - ribosomal protein lateral stalk subunit P1 Gene

Also Known as P1; LP1; RPP1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6176

About RPLP1

Cytogenetic location: 15q23 Genomic coordinates (GRCh38): 15:69,452,818-69,456,205 (from NCBI)

This gene has 5 transcripts (splice variants), 152 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 1137.8), ovary (RPKM 979.2) and 25 other tissues.

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal phosphoprotein that is a component of the 60S subunit. The protein, which is a functional equivalent of the E. coli L7/L12 ribosomal protein, belongs to the L12P family of ribosomal proteins. It plays an important role in the elongation step of protein synthesis. Unlike most ribosomal proteins, which are basic, the encoded protein is acidic. Its C-terminal end is nearly identical to the C-terminal ends of the ribosomal phosphoproteins P0 and P2. The P1 protein can interact with P0 and P2 to form a pentameric complex consisting of P1 and P2 dimers, and a P0 monomer. The protein is located in the cytoplasm. Two alternatively spliced transcript variants that encode different proteins have been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

RPLP1 Products (2)

mRNA	Protein	Name
NM_001003.3	NP_000994.1	60S acidic ribosomal protein P1 isoform 1
NM_213725.2	NP_998890.1	60S acidic ribosomal protein P1 isoform 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12054647	GOA
enables structural constituent of ribosome	IDA IDA: Inferred from direct assay	3323886	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of cytosolic large ribosomal subunit	IDA IDA: Inferred from direct assay	3323886	GOA
part of cytosolic large ribosomal subunit	IPI IPI: Inferred from physical interaction	25901680	GOA
located in cytosolic ribosome	IDA IDA: Inferred from direct assay	23636399	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RPLP1 Protein Structure

Ribosomal_60s

0
100
114 a.a.

Protein Preferred Names	Protein Names
60S acidic ribosomal protein P1	acidic ribosomal phosphoprotein P1

RPLP1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RPLP1	P05386	RPLP2	Homo sapiens	P05387	NMR	22135285
Intra	RPLP1	P05386	RPLP2	Homo sapiens	P05387	Pull Down	22135285
Intra	RPLP1	P05386	SUOX	Homo sapiens	P51687	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant RPLP1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76581	RPLP1 Protein, Human (sf9, His)	P05386-1/NP_000994.1 (M1-D114)	≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Branchiootorenal Syndrome 2	BOR2 Bor Syndrome 2 Branchiootorenal Dysplasia 2 Branchio-Oto-Renal Dysplasia 2 Branchio-Oto-Renal Syndrome Type 2 Branchiootorenal Syndrome, Type 2
Melanotic Neuroectodermal Tumor	Melanotic Neuroectodermal Tumor Of Infancy Neuroectodermal Tumor, Melanotic Infantile Melanotic Neuroectodermal Neoplasm Melanotic Neuroectodermal Tumour Melanotic Neuroectodermal Tumour Of Infancy Pigmented Neuroectodermal Tumour Of Infancy
Diamond-Blackfan Anemia	Congenital Pure Red Cell Aplasia Aase Syndrome Erythrogenesis Imperfecta Anemia, Diamond-Blackfan Congenital Hypoplastic Anemia Aase-Smith Ii Syndrome Bds Blackfan-Diamond Anemia Congenital Prca Congenital Hypoplastic Anemia, Blackfan-Diamond Type Dba Blackfan - Diamond Syndrome Chronic Constitutional Pure Red Cell Anaemia Anemia Diamond Blackfan Type Anemia Congenital Erythroid Hypoplastic Aregenerative Anemia Chronic Congenital Blackfan Diamond Syndrome Red Cell Aplasia, Pure Hereditary Aase-Smith Syndrome Ii Bda Blackfan Diamond Anemia Blackfan-Diamond Disease Blackfan-Diamond Syndrome Chronic Congenital Agenerative Anemia Congenital Erythroid Hypoplastic Anemia Congenital Hypoplastic Anemia Of Blackfan And Diamond Congenital Pure Red Cell Anemia Hypoplastic Congenital Anemia Inherited Erythroblastopenia Pure Hereditary Red Cell Aplasia Anemia, Hypoplastic, Congenital Anemia Hypoplastic Congenital Fanconi Anemia Constitutional Aplastic Anemia Diamond-Blackfan Anemia 1 Aase Smith Syndrome 2 Congenital Red Cell Aplasia Red Cell Aplasia Of Infants Pure Red Cell Aplasia Of Infants Congenital Red Cell Aplastic Anaemia Congenital Pure Red Cell Anaemia Congenital Erythroid Hypoplasia Pearson Marrow-Pancreas Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12208	RPLP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20484	Rplp1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26992	Rplp1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RPLP1	MGD	MGI:1927099
Rattus norvegicus	RPLP1	RGD	RGD:621774
Bos taurus	RPLP1	VGNC	VGNC:55142
Others	RPLP1	NCBI