SLC22A23 - solute carrier family 22 member 23 Gene

Also Known as C6orf85

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 63027

About SLC22A23

Cytogenetic location: 6p25.2 Genomic coordinates (GRCh38): 6:3,268,973-3,457,050 (from NCBI)

This gene has 12 transcripts (splice variants), 327 orthologues and 22 paralogues. Ubiquitous expression in stomach (RPKM 8.9), colon (RPKM 8.8) and 25 other tissues.

Summary

SLC22A23 belongs to a large family of transmembrane proteins that function as uniporters, symporters, and antiporters to transport organic ions across cell membranes (Jacobsson et al., 2007 [PubMed 17714910]).[supplied by OMIM, Mar 2008]

SLC22A23 Products (9)

mRNA Protein Name
NM_001286455.1 NP_001273384.1 solute carrier family 22 member 23 isoform b
NM_001286456.2 NP_001273385.1 solute carrier family 22 member 23 isoform c
NM_001382317.1 NP_001369246.1 solute carrier family 22 member 23 isoform d
NM_001382318.1 NP_001369247.1 solute carrier family 22 member 23 isoform e
NM_001382319.1 NP_001369248.1 solute carrier family 22 member 23 isoform f
NM_001382320.1 NP_001369249.1 solute carrier family 22 member 23 isoform g
NM_001382321.1 NP_001369250.1 solute carrier family 22 member 23 isoform h
NM_015482.2 NP_056297.1 solute carrier family 22 member 23 isoform a
NM_021945.6 NP_068764.3 solute carrier family 22 member 23 isoform b

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC22A23 Protein Structure

Sugar_tr

Sugar_tr: Sugar (and other) transporter (235 - 623)

  • 0
  • 200
  • 400
  • 600
  • 686 a.a.
Protein Preferred Names Protein Names

solute carrier family 22 member 23

  • ion transporter protein

SLC22A23 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
SLC22A23 A1A5C7 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
Intra
SLC22A23 A1A5C7 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra
SLC22A23 A1A5C7 KRTAP5-9 Homo sapiens P26371
Y2H Array
25416956
Intra
SLC22A23 A1A5C7 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra
SLC22A23 A1A5C7 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra
SLC22A23 A1A5C7 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
31515488
Intra
SLC22A23 A1A5C7 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Wolf-Hirschhorn Syndrome

  • Pitt-Rogers-Danks Syndrome

  • WHS

  • Chromosome 4p16.3 Deletion Syndrome

  • Wittwer Syndrome

  • 4p- Syndrome

  • Pitt Syndrome

  • 4p Deletion Syndrome

  • Distal Deletion 4p

  • Distal Monosomy 4p

  • Telomeric Deletion 4p

  • Prds

  • 4p Syndrome

  • Chromosome 4p Syndrome

  • Microcephaly, Iugr, Hypertelorism, Ptosis, Iris Coloboma, Hooked Nose, External Ear Dysplasia, Psychomotor Retardation

  • Wolf Syndrome

  • Chromosome 4p Deletion Syndrome

  • Chromosome 4p Monosomy

  • Del Syndrome

  • Monosomy 4p

  • Partial Monosomy 4p

  • Chromosome 4 Short Arm Deletion
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS13073 SLC22A23 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta SLC22A23 VGNC VGNC:83466
Mus musculus SLC22A23 MGD MGI:1920352
Rattus norvegicus SLC22A23 RGD RGD:620302
Canis familiaris SLC22A23 VGNC VGNC:59141
Bos taurus SLC22A23 VGNC VGNC:54236
Felis catus SLC22A23 VGNC VGNC:65244
Others SLC22A23 NCBI