SCN3A - sodium voltage-gated channel alpha subunit 3 Gene

Homo sapiens

Also known as NAC3; DEE62; EIEE62; FFEVF4; Nav1.3

Gene ID: 6328 | Gene type: protein coding

About SCN3A

Cytogenetic location: 2q24.3 Genomic coordinates (GRCh38): 2:165,087,526-165,204,050 (from NCBI)

This gene has 12 transcripts (splice variants), 130 orthologues, 26 paralogues and is associated with 4 phenotypes. Biased expression in brain (RPKM 5.7), adrenal (RPKM 1.1) and 11 other tissues.

Summary

Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the Sodium Channel alpha subunit gene family, and is found in a cluster of five alpha subunit genes on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

SCN3A Products(13)

mRNA	Protein	Name
XM_017004661.3	XP_016860150.1	sodium channel protein type 3 subunit alpha isoform X3
NM_006922.4	NP_008853.3	sodium channel protein type 3 subunit alpha isoform 1
XM_017004660.3	XP_016860149.1	sodium channel protein type 3 subunit alpha isoform X1
XM_017004665.2	XP_016860154.1	sodium channel protein type 3 subunit alpha isoform X9
NM_001081677.2	NP_001075146.1	sodium channel protein type 3 subunit alpha isoform 3
XM_047445394.1	XP_047301350.1	sodium channel protein type 3 subunit alpha isoform X4
NM_001081676.2	NP_001075145.1	sodium channel protein type 3 subunit alpha isoform 2
XM_011511610.4	XP_011509912.1	sodium channel protein type 3 subunit alpha isoform X2
XM_017004662.3	XP_016860151.1	sodium channel protein type 3 subunit alpha isoform X5
XM_047445395.1	XP_047301351.1	sodium channel protein type 3 subunit alpha isoform X7
XM_011511613.4	XP_011509915.1	sodium channel protein type 3 subunit alpha isoform X6
XM_017004664.2	XP_016860153.1	sodium channel protein type 3 subunit alpha isoform X8
XM_017004666.2	XP_016860155.1	sodium channel protein type 3 subunit alpha isoform X10

SCN3A Protein Structure

Ion_trans

Na_trans_cytopl

Ion_trans

Na_trans_assoc

Ion_trans

0
400
800
1200
1600
2000 a.a.

Protein Preferred Names

Protein Names

sodium channel protein type 3 subunit alpha

brain III voltage-gated sodium channel	sodium channel protein brain III subunit alpha
sodium channel protein type III subunit alpha	sodium channel, voltage gated, type III alpha subunit
sodium channel, voltage-gated, type III, alpha polypeptide	voltage-gated sodium channel subtype III
voltage-gated sodium channel subunit alpha Nav1.3

Related Diseases

Diseases

Alias

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Migraine, Familial Hemiplegic, 3

FHM3	Familial Hemiplegic Migraine 3
Mhp3	Migraine, Hemiplegic, Familial, Type 3

Progressive Familial Heart Block, Type Ia

PFHB1A	Bundle Branch Block
Heart Block, Nonprogressive	Lenegre-Lev Disease
Hereditary Bundle Branch System Defect	Progressive Familial Heart Block Type Ia
Pfhbia	Pccd
Hbbd	Progressive Familial Heart Block, Type 1a
Heart Block, Progressive Familial, Type I	Pfhbi
Cardiac Conduction Defect, Progressive	Heart Block, Progressive, Type Ia
Progressive Familial Heart Block Type 1a	Familial Progressive Cardiac Conduction Defect
Heart Block Progressive Familial Type 1	Familial Lenègre Disease
Familial Lev Disease	Familial Lev-Lenègre Disease
Familial Pccd	Familial Progressive Heart Block
Hereditary Bundle Branch Defect	Progressive Familial Heart Block
Progressive Familial Heart Block 1a	Cardiac Conduction Defect
Progressive Cardiac Conduction Defect	Progressive Familial Heart Block Type I
Heart Block, Progressive, Familial, Type 1a	Bundle-Branch Block
Conduction Disorder Of The Heart

Epilepsy, Idiopathic Generalized 12

EIG12	Epilepsy, Idiopathic Generalized, Susceptibility To, 12
Idiopathic Generalized Epilepsy 12	Susceptibility To Idiopathic Generalized Epilepsy 12
Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 12

Early Infantile Epileptic Encephalopathy

Early Infantile Epileptic Encephalopathy With Suppression Bursts	Early Infantile Epileptic Encephalopathy With Burst-Suppression
Eiee	Early Infantile Epileptic Encephalopathy With Suppression-Bursts
Ohtahara Syndrome	Encephalopathy, Epileptic, Early Infantile

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Dravet Syndrome

Severe Myoclonic Epilepsy Of Infancy	Smei
Severe Myoclonic Epilepsy In Infancy	Epileptic Encephalopathy, Early Infantile, 6
DRVT	Developmental And Epileptic Encephalopathy 6a
Dee6a	Eiee6
Dee6	Developmental And Epileptic Encephalopathy 6
Early Infantile Epileptic Encephalopathy 6	Myoclonic Epilepsy, Severe, Of Infancy
Sme	Severe Myoclonus Epilepsy Of Infancy
Borderline Smei	Smeb
Smeb-M	Smeb-O
Smeb-Sw	Smei-Borderland
Smei-Borderland More Than One Feature	Smei-Borderland-Myoclonic Seizures
Smei-Borderland-Spike Wave	Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures
ICEGTC	Developmental And Epileptic Encephalopathy, 6
Infantile Severe Myoclonic Epilepsy	Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures

Autonomic Nervous System Disease

Autonomic Nervous System Dysfunction	Autonomic Nervous System Disorders
Autonomic Nervous System Disorder	Autonomic Nervous System Diseases
Abnormality Of The Autonomic Nervous System

West Syndrome

Infantile Spasms	Infantile Spasms Syndrome
Infantile Spasm	X-Linked Infantile Spasm Syndrome
X-Linked Infantile Spasms	Epileptic Encephalopathy, Early Infantile, 1
Is	Tonic Spasms With Clustering, Arrest Of Psychomotor Development And Hypsarrhythmia On Eeg
West'S Syndrome	Spasms, Infantile
Is -[Infantile Spasm]	Salaam Spasm
Salaam Tic

Epilepsy, Idiopathic Generalized

Idiopathic Generalized Epilepsy	Generalised Epilepsy
Epilepsy, Generalized	EIG
Ige	Epilepsy, Idiopathic Generalized, Susceptibility To, 1
Epilepsy, Idiopathic Generalized 1	Epilepsy, Idiopathic Generalized, Susceptibility To
Epilepsy, Idiopathic, Generalized	Epilepsy, Idiopathic, Generalized, Susceptibility To, Type 1

Paroxysmal Extreme Pain Disorder

PEPD	Familial Rectal Pain
Pexpd	Submandibular, Ocular, And Rectal Pain With Flushing
Pain, Submandibular, Ocular, And Rectal, With Flushing	Rectal Pain, Familial
Submandibular, Ocular And Rectal Pain With Flushing	Familial Rectal Syndrome
Frp	Pain Disorder, Paroxysmal, Extreme

Polymicrogyria, Bilateral Perisylvian, X-Linked

Bilateral Perisylvian Polymicrogyria	Polymicrogyria, Bilateral Perisylvian
Pmgx	Perisylvian Syndrome, Congenital Bilateral
Cbps	Congenital Bilateral Perisylvian Syndrome
Perisylvian Syndrome	BPPX
Bpp

Episodic Pain Syndrome, Familial, 3

FEPS3	Familial Episodic Pain Syndrome With Predominantly Lower Limb Involvement
Familial Episodic Pain Syndrome 3

Neonatal Period Electroclinical Syndrome

Generalized Epilepsy With Febrile Seizures Plus

Gefs+	Genetic Epilepsy With Febrile Seizures Plus
Generalized Epilepsy With Febrile Seizures-Plus	Genetic Epilepsy With Febrile Seizures-Plus
Epilepsy, Generalized, With Febrile Seizures Plus

Scn3a-Related Neurodevelopmental Disorder

Abnormality Of Glucagon Secretion

Glucagon Secretion Abnormality

Abnormality Of Secretion Of Glucagon

Familial Hemiplegic Migraine

Hemiplegic Migraine, Familial	Hemiplegic-Ophthalmoplegic Migraine
Fhm	Hemiplegic Migraine Familial

Temporal Lobe Epilepsy

Epilepsy, Temporal Lobe

Epilepsy Temporal Lobe

Paine Syndrome

Pain Disorder	Pain
Microcephaly With Spastic Diplegia	Pain Syndrome

Non-Specific Early-Onset Epileptic Encephalopathy

Undetermined Early-Onset Epileptic Encephalopathy	Non-Specific Eoee
Undetermined Eoee

Long Qt Syndrome

Romano-Ward Syndrome	Long Q-T Syndrome
Lqt	Qt Syndrome, Long
Congenital Long Qt Syndrome	Familial Long Qt Syndrome

Trigeminal Nerve Disease

Trigeminal Nerve Diseases	Disorders Of 5th Cranial Nerve
Disorders Of The Fifth Cranial Nerve

Somatoform Disorder

Physiological Malfunction Arising From Mental Factor	Psychosomatic Disorder
Psychophysiologic Disorders

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Parietal Foramina

Enlarged Parietal Foramina	Hereditary Cranium Bifidum
Symmetric Parietal Foramina	Catlin Marks
Foramina Parietalia Permagna	Caitlin Marks
Cranium Bifidum	Cranium Bifidum Occultum
Fenestrae Parietals Symmetricae	Fpp
Giant Parietal Foramina	Pfm
Fenestrae Parietales Symmetricae	Foramina, Parietal

Lennox-Gastaut Syndrome

Epileptic Encephalopathy Lennox-Gastaut Type	Lennox Syndrome
Encephalopathy Of Childhood	Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves
Lgs

Childhood Absence Epilepsy

Pyknolepsy	Petit Mal Epilepsy
Absence Seizures	Absence Seizure
Petit Mal Seizure	Absence Epilepsy, Childhood
Pykno-Epilepsy	Epilepsy, Absence
Absence Epilepsy	Pycnolepsy

Episodic Pain Syndrome, Familial, 2

FEPS2

Familial Episodic Pain Syndrome 2

Developmental And Epileptic Encephalopathy 13

Epileptic Encephalopathy, Early Infantile, 13	DEE13
Eiee13	Developmental And Epileptic Encephalopathy, 13
Early Infantile Epileptic Encephalopathy 13	Scn8a Encephalopathy
Early Infantile Epileptic Encephalopathy-13	Scn8a Epilepsy
Encephalopathy, Developmental And Epileptic, Type 13

Polymicrogyria

Pmg

Erythromelalgia

Primary Erythromelalgia	Erythermalgia
Primary Erythermalgia	Mitchell Disease
Familial Erythromelalgia

Diabetic Neuropathy

Diabetic Neuropathies

Dystonia 9

DYT9	Choreoathetosis/Spasticity, Episodic
Episodic Choreoathetosis/Spasticity	Cse Choreoathetosis, Paroxysmal, With Episodic Ataxia
Choreoathetosis, Kinesigenic, With Episodic Ataxia And Spasticity	Paroxysmal Dystonic Choreathetosis With Episodic Ataxia And Spasticity
Cse	Dystonia-9
Kinesigenic Choreoathetosis With Episodic Ataxia And Spasticity	Paroxysmal Choreoathetosis With Episodic Ataxia
Dystonia, Type 9

Developmental And Epileptic Encephalopathy

Encephalopathy, Developmental And Epileptic

Familial Febrile Seizures

Familial Febrile Convulsions	Feb
Febrile Seizures, Familial

Epilepsy, Familial Focal, With Variable Foci 4

FFEVF4

Epilepsy, Familial Focal, With Variable Foci, Type 4

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Developmental And Epileptic Encephalopathy 62

DEE62	Epileptic Encephalopathy, Early Infantile, 62
Eiee62	Developmental And Epileptic Encephalopathy, 62
Early Infantile Epileptic Encephalopathy 62	Encephalopathy, Epileptic, Early Infantile, Type 62

Trigeminal Neuralgia

Tic Douloureux	Trifacial Neuralgia
Trifocal Neuralgia	Neuralgia Of The Fifth Cranial Nerve
Neuralgia Of 5th Cranial Nerve	Infraorbital Neuralgia

Benign Familial Infantile Epilepsy

Benign Familial Infantile Seizures	Bfie
Benign Familial Infantile Convulsion	Bfic
Bfis	Benign Familial Infantile Convulsions
Familial Benign Neonatal Epilepsy	Watanabe-Vigevano Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Purity	Rare Diseases
HY-RS12533	SCN3A Human Pre-designed siRNA Set A	/	Unkown
HY-RS12534	Scn3a Mouse Pre-designed siRNA Set A	/	Unkown
HY-RS12535	Scn3a Rat Pre-designed siRNA Set A	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SCN3A	RGD	RGD:3635
Mus musculus	SCN3A	MGD	MGI:98249
Bos taurus	SCN3A	VGNC	VGNC:55078
Felis catus	SCN3A	VGNC	VGNC:64922
Macaca mulatta	SCN3A	VGNC	VGNC:76985
Canis familiaris	SCN3A	VGNC	VGNC:45918