THADA - THADA armadillo repeat containing Gene

Also Known as GITA; ARMC13; Trm732

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 63892

About THADA

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:43,230,851-43,596,038 (from NCBI)

This gene has 19 transcripts (splice variants) and 201 orthologues. Ubiquitous expression in lymph node (RPKM 6.5), thyroid (RPKM 6.2) and 25 other tissues.

Summary

This gene is the target of 2p21 choromosomal aberrations in benign thyroid adenomas. Single nucleotide polymorphisms (SNPs) in this gene may be associated with type 2 diabetes and polycystic ovary syndrome. The encoded protein is likely involved in the death receptor pathway and Apoptosis. [provided by RefSeq, Sep 2016]

THADA Products (7)

mRNA Protein Name
NM_001083953.2 NP_001077422.1 thyroid adenoma-associated protein isoform a
NM_001271643.2 NP_001258572.1 thyroid adenoma-associated protein isoform b
NM_001271644.2 NP_001258573.1 thyroid adenoma-associated protein isoform c
NM_001345923.2 NP_001332852.1 thyroid adenoma-associated protein isoform d
NM_001345924.2 NP_001332853.1 thyroid adenoma-associated protein isoform e
NM_001345925.2 NP_001332854.1 thyroid adenoma-associated protein isoform a
NM_022065.5 NP_071348.3 thyroid adenoma-associated protein isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables enzyme regulator activity IGI
IGI: Inferred from genetic interaction
25404562 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of lipid homeostasis IGI
IGI: Inferred from genetic interaction
28399403 GOA
involved in negative regulation of endoplasmic reticulum calcium ion concentration IMP
IMP: Inferred from mutant phenotype
28399403 GOA
involved in tRNA methylation IGI
IGI: Inferred from genetic interaction
25404562 GOA
involved in tRNA nucleoside ribose methylation IGI
IGI: Inferred from genetic interaction
35559166 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

THADA Protein Structure

DUF2428

DUF2428: Putative death-receptor fusion protein (DUF2428) (945 - 1248)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1800
  • 1953 a.a.
Protein Preferred Names Protein Names

thyroid adenoma-associated protein

  • Trm732 homolog

THADA Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
THADA Q6YHU6 ATN1 Homo sapiens Q86V38
Validated Y2H
32814053
Intra
THADA Q6YHU6 ATN1 Homo sapiens Q86V38
Y2H Array
32814053
Intra
THADA Q6YHU6 ATN1 Homo sapiens Q86V38
Y2H Pooling
32814053
Intra
THADA Q6YHU6 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
25416956
Intra
THADA Q6YHU6 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Adenoma

  • Acinar Cell Adenoma

  • Adenomas

  • Acinic Cell Adenoma
Polycystic Ovary Syndrome

  • Polycystic Ovarian Syndrome

  • Pcos

  • Polycystic Ovarian Disease

  • Polycystic Ovaries

  • Stein-Leventhal Syndrome

  • Multicystic Ovaries

  • Polycystic Ovary

  • Sclerocystic Ovaries

  • Sclerocystic Ovary Syndrome

  • Stein-Leventhal Synd.

  • Cystic Disease Of Ovaries

  • Cystic Disease Of Ovary

  • Pco

  • Pcod

  • Sclerocystic Ovarian Degeneration

  • Polycystic Ovary Syndrome, Susceptibility To

  • Pcos - [Polycystic Ovary Syndrome]

  • Polycystic Ovary Nos

  • Pco - [Polycystic Ovary]
Hyperinsulinemic Hypoglycemia, Familial, 5

  • Hyperinsulinism Due To Insr Deficiency

  • HHF5

  • Familial Hyperinsulinemic Hypoglycemia 5

  • Hyperinsulinemic Hypoglycemia Due To Insr Deficiency

  • Hyperinsulinemic Hypoglycemia Due To Insulin Receptor Deficiency

  • Congenital Hyperinsulinism

  • Persistent Hyperinsulinemic Hypoglycemia Of Infancy

  • Phhi

  • Hyperinsulinemic Hypoglycemia Familial 5
Wolfram Syndrome 1

  • WFS1

  • Didmoad

  • Wfs

  • Diabetes Mellitus And Insipidus With Optic Atrophy And Deafness

  • Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness

  • Diabetes Insipidus And Mellitus With Optic Atrophy And Deafness Syndrome

  • Wolfram Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14468 THADA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21067 Thada Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27584 Thada Rat Pre-designed siRNA Set A Pre-designed Set / Unkown