DMRTA1 - DMRT like family A1 Gene

Also Known as DMO; DMRT4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 63951

About DMRTA1

Cytogenetic location: 9p21.3 Genomic coordinates (GRCh38): 9:22,446,824-22,455,740 (from NCBI)

This gene has 1 transcript (splice variant), 178 orthologues and 8 paralogues. Broad expression in liver (RPKM 4.0), kidney (RPKM 3.0) and 19 other tissues.

Summary

Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in germ cell development; regulation of transcription by RNA polymerase II; and sex differentiation. Predicted to act upstream of or within male mating behavior and ovarian follicle development. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

DMRTA1 Products (1)

mRNA Protein Name
NM_022160.3 NP_071443.2 doublesex- and mab-3-related transcription factor A1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: Inferred from direct assay
28473536 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DMRTA1 Protein Structure

DM

DM: DM DNA binding domain (93 - 139)

DMA

DMA: DMRTA motif (327 - 364)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 504 a.a.
Protein Preferred Names Protein Names

doublesex- and mab-3-related transcription factor A1

DMRTA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
DMRTA1 Q5VZB9 KIF1B Homo sapiens O60333-2
Validated Y2H
32814053
Intra
DMRTA1 Q5VZB9 KIF1B Homo sapiens O60333-2
Y2H Array
32814053
Intra
DMRTA1 Q5VZB9 KIF1B Homo sapiens O60333-2
Y2H Pooling
32814053
Intra
DMRTA1 Q5VZB9 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
Intra
DMRTA1 Q5VZB9 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
Intra
DMRTA1 Q5VZB9 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
Intra
DMRTA1 Q5VZB9 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
DMRTA1 Q5VZB9 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
DMRTA1 Q5VZB9 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Dermoid Cyst Of Ovary

  • Dermoid Cyst

  • Ovarian Dermoid Cyst

  • Teratoma, Ovarian
Diabetes Mellitus, Neonatal, With Congenital Hypothyroidism

  • Neonatal Diabetes Mellitus With Congenital Hypothyroidism

  • Ndh Syndrome

  • NDH

  • Neonatal Diabetes-Congenital Hypothyroidism-Congenital Glaucoma-Hepatic Fibrosis-Polycystic Kidneys Syndrome
Dermatopathia Pigmentosa Reticularis

  • DPR
Chronic Wasting Disease

  • Wasting Disease, Chronic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS03831 DMRTA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris DMRTA1 VGNC VGNC:51707
Bos taurus DMRTA1 VGNC VGNC:28113
Rattus norvegicus DMRTA1 RGD RGD:1309796
Macaca mulatta DMRTA1 VGNC VGNC:108198
Felis catus DMRTA1 VGNC VGNC:61530
Mus musculus DMRTA1 MGD MGI:2653627
Others DMRTA1 NCBI