CHST8 - carbohydrate sulfotransferase 8 Gene

Homo sapiens

Also known as PSS3; GalNAc4ST; GALNAC4ST1

Gene ID: 64377 | Gene type: protein coding

About CHST8

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:33,621,953-33,773,509 (from NCBI)

This gene has 6 transcripts (splice variants), 262 orthologues, 6 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex Hormones. Mice lacking this Enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

CHST8 Products(3)

mRNA	Protein	Name
NM_001127895.2	NP_001121367.1	carbohydrate sulfotransferase 8
NM_001127896.2	NP_001121368.1	carbohydrate sulfotransferase 8
NM_022467.3	NP_071912.2	carbohydrate sulfotransferase 8

CHST8 Protein Structure

Sulfotransfer_2

0
100
200
300
400
424 a.a.

Protein Preferred Names

Protein Names

carbohydrate sulfotransferase 8

GALNAC-4-ST1

Related Diseases

Diseases

Alias

Peeling Skin Syndrome 3

PSS3	Skin, Peeling Syndrome, Type 3

Peeling Skin Syndrome Type A

Generalized Deciduous Skin Type A	Generalized Peeling Skin Syndrome Type A
Non-Inflammatory Generalized Peeling Skin Syndrome Type A.	Non-Inflammatory Peeling Skin Syndrome Type A
Pss Type A

Peeling Skin Syndrome

Deciduous Skin	Familial Continuous Skin Peeling Syndrome
Idiopathic Deciduous Skin	Keratosis Exfoliativa Congenita
Pss	Peeling Skin Disease
Skin Peeling Syndrome	Familial Continuous Skin Peeling
Keratolysis Exfoliativa Congenita	Exfoliation Syndrome
Keratolysis Exfoliativa

Periarthritis

Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome	Chromosome 11p11.2 Deletion Syndrome
Pss	11p11.2 Deletion
P11pds	Defect11 Syndrome
Deletion Of Chromosome 11p11.2	POSHS

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02693	CHST8 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CHST8	VGNC	VGNC:27348
Macaca mulatta	CHST8	VGNC	VGNC:82124
Canis familiaris	CHST8	VGNC	VGNC:39258
Felis catus	CHST8	VGNC	VGNC:60892
Mus musculus	CHST8	MGD	MGI:1916197
Rattus norvegicus	CHST8	RGD	RGD:1308979

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