CHST8 - carbohydrate sulfotransferase 8 Gene

Also Known as PSS3; GalNAc4ST; GALNAC4ST1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 64377

About CHST8

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:33,621,953-33,773,509 (from NCBI)

This gene has 6 transcripts (splice variants), 262 orthologues, 6 paralogues and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

The protein encoded by this gene belongs to the sulfotransferase 2 family. It is predominantly expressed in the pituitary gland, and is localized to the golgi membrane. This protein catalyzes the transfer of sulfate to position 4 of non-reducing N-acetylgalactosamine (GalNAc) residues in both N-glycans and O-glycans. It is responsible for sulfation of GalNAc on luteinizing hormone (LH), which is required for production of the sex Hormones. Mice lacking this enzyme, exhibit increased levels of circulating LH, and precocious sexual maturation of both male and female mice. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2011]

CHST8 Products (3)

mRNA	Protein	Name
NM_001127895.2	NP_001121367.1	carbohydrate sulfotransferase 8
NM_001127896.2	NP_001121368.1	carbohydrate sulfotransferase 8
NM_022467.3	NP_071912.2	carbohydrate sulfotransferase 8

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables N-acetylgalactosamine 4-O-sulfotransferase activity	IDA IDA: Inferred from direct assay	10988300	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in hormone biosynthetic process	IEP IEP: Inferred from expression pattern	10988300	GOA
involved in proteoglycan biosynthetic process	IDA IDA: Inferred from direct assay	10988300	GOA
involved in sulfur compound metabolic process	IDA IDA: Inferred from direct assay	11445554	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHST8 Protein Structure

Sulfotransfer_2

0
100
200
300
400
424 a.a.

Protein Preferred Names	Protein Names
carbohydrate sulfotransferase 8	GALNAC-4-ST1

CHST8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CHST8	Q9H2A9	CHAT	Homo sapiens	P28329-3	Validated Y2H	32814053
Intra	CHST8	Q9H2A9	CHAT	Homo sapiens	P28329-3	Y2H Array	32814053
Intra	CHST8	Q9H2A9	CHAT	Homo sapiens	P28329-3	Y2H Pooling	32814053
Intra	CHST8	Q9H2A9	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	CHST8	Q9H2A9	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	CHST8	Q9H2A9	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	CHST8	Q9H2A9	GSN	Homo sapiens	P06396	Validated Y2H	32814053
Intra	CHST8	Q9H2A9	GSN	Homo sapiens	P06396	Y2H Pooling	32814053
Intra	CHST8	Q9H2A9	GSN	Homo sapiens	P06396	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Peeling Skin Syndrome 3	PSS3 Skin, Peeling Syndrome, Type 3
Peeling Skin Syndrome Type A	Generalized Deciduous Skin Type A Generalized Peeling Skin Syndrome Type A Non-Inflammatory Generalized Peeling Skin Syndrome Type A. Non-Inflammatory Peeling Skin Syndrome Type A Pss Type A
Peeling Skin Syndrome	Deciduous Skin Familial Continuous Skin Peeling Syndrome Idiopathic Deciduous Skin Keratosis Exfoliativa Congenita Pss Peeling Skin Disease Skin Peeling Syndrome Familial Continuous Skin Peeling Keratolysis Exfoliativa Congenita Exfoliation Syndrome Keratolysis Exfoliativa
Periarthritis
Potocki-Shaffer Syndrome	Proximal 11p Deletion Syndrome Chromosome 11p11.2 Deletion Syndrome Pss 11p11.2 Deletion P11pds Defect11 Syndrome Deletion Of Chromosome 11p11.2 POSHS

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02693	CHST8 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	CHST8	VGNC	VGNC:27348
Macaca mulatta	CHST8	VGNC	VGNC:82124
Canis familiaris	CHST8	VGNC	VGNC:39258
Felis catus	CHST8	VGNC	VGNC:60892
Mus musculus	CHST8	MGD	MGI:1916197
Rattus norvegicus	CHST8	RGD	RGD:1308979
Others	CHST8	NCBI