CERK - ceramide kinase Gene

Also Known as LK4; hCERK; dA59H18.2; dA59H18.3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 64781

About CERK

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:46,684,410-46,738,252 (from NCBI)

This gene has 4 transcripts (splice variants), 264 orthologues and 4 paralogues. Ubiquitous expression in small intestine (RPKM 16.4), duodenum (RPKM 15.6) and 25 other tissues.

Summary

CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, Apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]

CERK Products (1)

mRNA Protein Name
NM_022766.6 NP_073603.2 ceramide kinase

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables ceramide kinase activity IDA
IDA: Inferred from direct assay
11956206 GOA
enables magnesium ion binding IDA
IDA: Inferred from direct assay
10947957 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence References Source
involved in ceramide metabolic process IDA
IDA: Inferred from direct assay
19501188 GOA
Cellular Component GO Annotation Evidence References Source
located in membrane IDA
IDA: Inferred from direct assay
11956206 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
16269826 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CERK Protein Structure

DAGK_cat

DAGK_cat: Diacylglycerol kinase catalytic domain (132 - 275)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 537 a.a.
Protein Preferred Names Protein Names

ceramide kinase

  • acylsphingosine kinase

CERK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CERK Q8TCT0 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
Intra
CERK Q8TCT0 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
32296183
Intra
CERK Q8TCT0 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
32296183
Intra
CERK Q8TCT0 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
CERK Q8TCT0 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
CERK Q8TCT0 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
Intra
CERK Q8TCT0 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
Intra
CERK Q8TCT0 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
CERK Q8TCT0 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
CERK Q8TCT0 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra
CERK Q8TCT0 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra
CERK Q8TCT0 KRTAP19-6 Homo sapiens Q3LI70
Y2H Prey Pooling
32296183
Intra
CERK Q8TCT0 KRTAP19-6 Homo sapiens Q3LI70
Y2H Array
32296183
Intra
CERK Q8TCT0 KRTAP19-1 Homo sapiens Q8IUB9
Y2H Prey Pooling
32296183
Intra
CERK Q8TCT0 KRTAP19-1 Homo sapiens Q8IUB9
Y2H Array
32296183
Intra
CERK Q8TCT0 NHLRC4 Homo sapiens P0CG21
Y2H Prey Pooling
32296183
Intra
CERK Q8TCT0 NHLRC4 Homo sapiens P0CG21
Y2H Array
32296183
Intra
CERK Q8TCT0 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
CERK Q8TCT0 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
CERK Q8TCT0 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
CERK Q8TCT0 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
CERK Q8TCT0 TRIM42 Homo sapiens Q8IWZ5
Y2H Prey Pooling
32296183
Intra
CERK Q8TCT0 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
32296183
Intra
CERK Q8TCT0 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
Intra
CERK Q8TCT0 OIP5 Homo sapiens O43482
Y2H Array
32296183
Intra
CERK Q8TCT0 CRYBA1 Homo sapiens P05813
Y2H Prey Pooling
32296183
Intra
CERK Q8TCT0 CRYBA1 Homo sapiens P05813
Y2H Array
32296183
Intra
CERK Q8TCT0 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
Intra
CERK Q8TCT0 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
Intra
CERK Q8TCT0 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
Intra
CERK Q8TCT0 MTUS2 Homo sapiens Q5JR59
Y2H Array
25416956
Intra
CERK Q8TCT0 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
32296183
Intra
CERK Q8TCT0 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
32296183
Intra
CERK Q8TCT0 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Array
32296183
Intra
CERK Q8TCT0 KRTAP3-1 Homo sapiens Q9BYR8
Validated Y2H
32296183
Intra
CERK Q8TCT0 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Retinitis Pigmentosa 26

  • RP26

  • Retinitis Pigmentosa-26

  • Retinitis Pigmentosa, Type 26
Cochlear Disease

  • Cochlear Diseases
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Farber Lipogranulomatosis

  • Farber Disease

  • Acid Ceramidase Deficiency

  • Ceramidase Deficiency

  • Ac Deficiency

  • N-Laurylsphingosine Deacylase Deficiency

  • Farber'S Disease

  • FRBRL

  • Farber'S Lipogranulomatosis

  • Acylsphingosine Deacylase Deficiency

  • Farber-Uzman Syndrome

  • Acy
Hereditary Sensory And Autonomic Neuropathy Type 1

  • Hereditary Sensory And Autonomic Neuropathy Type I

  • Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome

  • Hsan1e

  • Hsan1

  • Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy

  • Hsn1e

  • Hsnie

  • Hereditary Sensory Neuropathy Type Ie

  • Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome

  • Hereditary Sensory And Autonomic Neuropathy Type Ie

  • Hereditary Sensory And Autonomic Neuropathy Type 1e

  • Hereditary Sensory Neuropathy With Hearing Loss And Dementia

  • Dnmt1-Complex Disorder

  • Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss

  • Hsn Ie

  • Hereditary Sensory Autonomic Neuropathy, Type 1

  • Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]
Retinal Degeneration

  • Degeneration Of Retina
Intracranial Berry Aneurysm

  • Familial Aneurysmal Subarachnoid Hemorrhage

  • Familial Berry Aneurysm

  • Familial Intracranial Saccular Aneurysm

  • Saccular Cerebral Aneurysm

  • Aneurysm, Intracranial Berry

  • Aneurysmal Subarachnoid Hemorrhage

  • Aneurysm, Intracranial Berry, 1
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Cone-Rod Dystrophy 2

  • Cone-Rod Dystrophy

  • CORD2

  • Cone-Rod Retinal Dystrophy

  • Rcrd2

  • Cone-Rod Retinal Dystrophy 2

  • Crd2

  • Cord

  • Crd

  • Retinal Cone-Rod Dystrophy

  • Cone-Rod Retinal Dystrophy-2

  • Retinal Cone-Rod Dystrophy 2

  • Tapetoretinal Degeneration

  • Cone-Rod Degeneration

  • Cone Rod Dystrophy

  • Dystrophy, Cone-Rod

  • Dystrophy, Cone-Rod, Type 2

  • Retinitis Pigmentosa

  • Retinitis Pigmentosa 2

  • Progressive Cone-Rod Dystrophy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13945 NVP 231 Inducer 99.73% Unkown
HY-RS02534 CERK Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19583 Cerk Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26080 Cerk Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus CERK RGD RGD:1305019
Canis familiaris CERK VGNC VGNC:54519
Macaca mulatta CERK VGNC VGNC:71030
Bos taurus CERK VGNC VGNC:55885
Felis catus CERK VGNC VGNC:83527
Mus musculus CERK MGD MGI:2386052
Others CERK NCBI