2. Gene
  3. Pik3c3 - phosphatidylinositol 3-kinase, catalytic subunit type 3 Gene

Pik3c3 - phosphatidylinositol 3-kinase, catalytic subunit type 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 65052 | Gene type: protein coding

About Pik3c3

Primary_assembly 18: 21,845,295-21,929,048 forward strand.mRatBN7.2:CM026991.1

This gene has 3 transcripts (splice variants), 210 orthologues, 9 paralogues and is associated with 1 phenotype. Biased expression in Thymus (RPKM 128.6), Kidney (RPKM 122.) and 9 other tissues.

Summary

Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including autophagosome assembly; phosphatidylinositol-mediated signaling; and response to leucine. Predicted to be located in several cellular components, including autolysosome; cytoplasmic vesicle; and midbody. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in several cellular components, including endosome; peroxisome; and phagophore assembly site. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3). [provided by Alliance of Genome Resources, Apr 2022]

Pik3c3 Products(1)

mRNA Protein Name
NM_022958.2 NP_075247.1 phosphatidylinositol 3-kinase catalytic subunit type 3

Pik3c3 Protein Structure

C2_PI3K_class_III

C2_PI3K_class_III: cd08397 (25 - 185)

PI3Ka_III

PI3Ka_III: cd00870 (282 - 502)

PI3Kc_III

PI3Kc_III: cd00896 (538 - 882)

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  • 887 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 3-kinase catalytic subunit type 3

PI-3K Vps34p

PI3-kinase type 3

PI3K type 3

catalytic phosphatidylinositol 3-kinase 3

phosphoinositide-3-kinase, class 3

ptdIns-3-kinase type 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12481 SAR405 Inhibitor 98.99% Unkown
HY-137506 XST-14 99.69% Unkown
HY-12481A SAR405 R enantiomer 99.78% Unkown
HY-RS10520 PIK3C3 Human Pre-designed siRNA Set A / Unkown
HY-RS10521 Pik3c3 Mouse Pre-designed siRNA Set A / Unkown
HY-RS10522 Pik3c3 Rat Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pik3c3 NCBI NCBI:5289