Pik3c3 - phosphatidylinositol 3-kinase, catalytic subunit type 3 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 65052

About Pik3c3

Primary_assembly 18: 21,845,295-21,929,048 forward strand.mRatBN7.2:CM026991.1

This gene has 3 transcripts (splice variants), 210 orthologues, 9 paralogues and is associated with 1 phenotype. Biased expression in Thymus (RPKM 128.6), Kidney (RPKM 122.) and 9 other tissues.

Summary

Enables 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including autophagosome assembly; phosphatidylinositol-mediated signaling; and response to leucine. Predicted to be located in several cellular components, including autolysosome; cytoplasmic vesicle; and midbody. Predicted to be part of phosphatidylinositol 3-kinase complex, class III, type I and phosphatidylinositol 3-kinase complex, class III, type II. Predicted to be active in several cellular components, including endosome; peroxisome; and phagophore assembly site. Orthologous to human PIK3C3 (phosphatidylinositol 3-kinase catalytic subunit type 3). [provided by Alliance of Genome Resources, Apr 2022]

Pik3c3 Products (1)

mRNA Protein Name
NM_022958.2 NP_075247.1 phosphatidylinositol 3-kinase catalytic subunit type 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 1-phosphatidylinositol-3-kinase activity IDA
IDA: Inferred from direct assay
12244116 RGD
Biological Process GO Annotation Evidence References Source
involved in autophagosome assembly IMP
IMP: Inferred from mutant phenotype
12453151 RGD
involved in endosome organization IMP
IMP: Inferred from mutant phenotype
12453151 RGD
involved in phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: Inferred from mutant phenotype
12244116 RGD
involved in protein processing IMP
IMP: Inferred from mutant phenotype
11171063 RGD
involved in response to L-leucine IEP
IEP: Inferred from expression pattern
19015198 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Pik3c3 Protein Structure

C2_PI3K_class_III

C2_PI3K_class_III: cd08397 (25 - 185)

PI3Ka_III

PI3Ka_III: cd00870 (282 - 502)

PI3Kc_III

PI3Kc_III: cd00896 (538 - 882)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 887 a.a.
Protein Preferred Names Protein Names

phosphatidylinositol 3-kinase catalytic subunit type 3

  • PI-3K Vps34p

  • PI3-kinase type 3

  • PI3K type 3

  • catalytic phosphatidylinositol 3-kinase 3

  • phosphoinositide-3-kinase, class 3

  • ptdIns-3-kinase type 3

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-12481 SAR405 Inhibitor 99.74% Unkown
HY-137506 XST-14 99.26% Unkown
HY-12481A SAR405 R enantiomer Control 99.94% Unkown
HY-RS10521 Pik3c3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-122888 MPT0L145 / Unkown
HY-181062 VWK147 / Unkown
HY-RS10520 PIK3C3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10522 Pik3c3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pik3c3 NCBI NCBI:5289