TMEM135 - transmembrane protein 135 Gene

Also Known as PMP52

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 65084

About TMEM135

Cytogenetic location: 11q14.2 Genomic coordinates (GRCh38): 11:87,037,934-87,328,824 (from NCBI)

This gene has 9 transcripts (splice variants), 222 orthologues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 8.2), adrenal (RPKM 4.0) and 24 other tissues.

Summary

Predicted to be involved in peroxisome organization. Predicted to act upstream of or within response to cold and response to food. Predicted to be located in mitochondrion and peroxisome. [provided by Alliance of Genome Resources, Apr 2022]

TMEM135 Products (2)

mRNA	Protein	Name
NM_001168724.2	NP_001162195.1	transmembrane protein 135 isoform 2
NM_022918.4	NP_075069.3	transmembrane protein 135 isoform 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	33961781	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
transmembrane protein 135	peroxisomal membrane protein 52

TMEM135 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TMEM135	Q86UB9	BIRC6	Homo sapiens	Q9NR09	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Joubert Syndrome 30	JBTS30 Joubert Syndrome, Type 30
Retinal Dystrophy With Leukodystrophy	RDLKD Acbd5 Deficiency Dystrophy, Retinal, With Leukodystrophy
Peroxisomal Biogenesis Disorder	Zellweger Spectrum Disorders Peroxisome Biogenesis Disorder-Zellweger Syndrome Spectrum Disorders Of Peroxisome Biogenesis Zellweger Spectrum Zellweger Syndrome Spectrum Peroxisomal Biogenesis Disorders Pbd, Zss Pbd-Zsd Pbd-Zss Pbd-Zellweger Spectrum Disorder Peroxisomal Biogenesis Disorders, Zellweger Syndrome Spectrum Peroxisome Biogenesis Disorder Peroxisome Biogenesis Disorder Spectrum Peroxisome Biogenesis Disorders Zellweger Spectrum Disorder Hyperpipecolic Acidaemia
Zellweger Syndrome	Cerebrohepatorenal Syndrome Zellweger Leukodystrophy Zs Congenital Iron Overload Chr Zws Severe Pbd-Zsd Severe Peroxisome Biogenesis Disorder-Zellweger Spectrum Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14667	TMEM135 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TMEM135	VGNC	VGNC:56288
Canis familiaris	TMEM135	VGNC	VGNC:47473
Mus musculus	TMEM135	MGD	MGI:1920009
Felis catus	TMEM135	VGNC	VGNC:66273
Rattus norvegicus	TMEM135	RGD	RGD:1309948
Macaca mulatta	TMEM135	VGNC	VGNC:79585