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Prkaa1 - protein kinase AMP-activated catalytic subunit alpha 1 Gene

Also Known as AMPKalpha1

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 65248

Summary

Enables several functions, including AMP-activated protein kinase activity; ATP binding activity; and protein C-terminus binding activity. Involved in several processes, including cold acclimation; energy homeostasis; and fatty acid homeostasis. Located in several cellular components, including apical plasma membrane; dendrite; and neuronal cell body. Part of nucleotide-activated protein kinase complex. Used to study type 2 diabetes mellitus. Biomarker of cholestasis. Human ortholog(s) of this gene implicated in Huntington's disease; breast cancer; colon cancer; and lung non-small cell carcinoma. Orthologous to human PRKAA1 (protein kinase AMP-activated catalytic subunit alpha 1). [provided by Alliance of Genome Resources, Apr 2022]

Prkaa1 Products (1)

mRNA	Protein	Name
NM_019142.3	NP_062015.2	5'-AMP-activated protein kinase catalytic subunit alpha-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables AMP-activated protein kinase activity	IDA IDA: Inferred from direct assay	11069105	RGD
enables AMP-activated protein kinase activity	IMP IMP: Inferred from mutant phenotype	8955377	RGD
enables ATP binding	IDA IDA: Inferred from direct assay	16648175	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	11069105	RGD
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	8955377	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	14511394	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to calcium ion	IMP IMP: Inferred from mutant phenotype	25788287	RGD
involved in cellular response to ethanol	IEP IEP: Inferred from expression pattern	20164678	RGD
involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	25788287	RGD
involved in cellular response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	18081811	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	17720864	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	27090119	RGD
involved in cold acclimation	IDA IDA: Inferred from direct assay	21945600	RGD
involved in energy homeostasis	IDA IDA: Inferred from direct assay	11724780	RGD
involved in fatty acid homeostasis	IDA IDA: Inferred from direct assay	11724780	RGD
involved in negative regulation of insulin receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	20501641	RGD
involved in positive regulation of cell population proliferation	IDA IDA: Inferred from direct assay	17720864	RGD
involved in positive regulation of glycolytic process	IDA IDA: Inferred from direct assay	11069105	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	8955377	RGD
involved in regulation of vesicle-mediated transport	IMP IMP: Inferred from mutant phenotype	19139597	RGD
involved in response to activity	IDA IDA: Inferred from direct assay	17253964	RGD
involved in response to caffeine	IDA IDA: Inferred from direct assay	19608206	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	27090119	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	29091898	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	18256313	RGD
located in axon	IMP IMP: Inferred from mutant phenotype	25788287	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	18256313	RGD
located in cytosol	IDA IDA: Inferred from direct assay	27090119	RGD
located in dendrite	IMP IMP: Inferred from mutant phenotype	25788287	RGD
located in neuronal cell body	IMP IMP: Inferred from mutant phenotype	25788287	RGD
part of nucleotide-activated protein kinase complex	IDA IDA: Inferred from direct assay	16648175	RGD
located in nucleus	IDA IDA: Inferred from direct assay	27090119	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	14511394	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
5'-AMP-activated protein kinase catalytic subunit alpha-1	ACACA kinase AMPK alpha-1 chain HMGCR kinase acetyl-CoA carboxylase kinase hydroxymethylglutaryl-CoA reductase kinase protein kinase, AMP-activated, alpha 1 catalytic subunit tau-protein kinase PRKAA1

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148065	FMF-06-098-1	Inhibitor	98.77%	Unkown
HY-RS11100	PRKAA1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P11779	Ac-RKAA-PABC-MMAE	Inhibitor	/	Unkown
HY-P11779A	Ac-RKAA-PABC-MMAE TFA	Inhibitor	/	Unkown
HY-RS29496	Prkaa1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-185634	PROTAC GSK3 degrader-1		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Prkaa1	NCBI	NCBI:5562