SLCO1A2 - solute carrier organic anion transporter family member 1A2 Gene

Also Known as OATP; OATP-A; OATP1A2; SLC21A3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6579

About SLCO1A2

Cytogenetic location: 12p12.1 Genomic coordinates (GRCh38): 12:21,264,600-21,419,634 (from NCBI)

This gene has 17 transcripts (splice variants), 159 orthologues and 10 paralogues. Biased expression in brain (RPKM 6.2), lung (RPKM 0.9) and 2 other tissues.

Summary

This gene encodes a sodium-independent transporter which mediates cellular uptake of organic ions in the liver. Its substrates include bile acids, bromosulphophthalein, and some steroidal compounds. The protein is a member of the SLC21A family of solute carriers. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2008]

SLCO1A2 Products (37)

mRNA Protein Name
NM_001386878.1 NP_001373807.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_001386879.1 NP_001373808.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_001386880.1 NP_001373809.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_001386881.1 NP_001373810.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_001386882.2 NP_001373811.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_001386886.1 NP_001373815.1 solute carrier organic anion transporter family member 1A2 isoform 2
NM_001386887.1 NP_001373816.1 solute carrier organic anion transporter family member 1A2 isoform 4
NM_001386890.1 NP_001373819.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386908.1 NP_001373837.1 solute carrier organic anion transporter family member 1A2 isoform 8
NM_001386919.1 NP_001373848.1 solute carrier organic anion transporter family member 1A2 isoform 8
NM_001386920.1 NP_001373849.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386921.1 NP_001373850.1 solute carrier organic anion transporter family member 1A2 isoform 10 precursor
NM_001386922.1 NP_001373851.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386926.1 NP_001373855.1 solute carrier organic anion transporter family member 1A2 isoform 2
NM_001386927.1 NP_001373856.1 solute carrier organic anion transporter family member 1A2 isoform 8
NM_001386929.1 NP_001373858.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386931.1 NP_001373860.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386937.1 NP_001373866.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386938.1 NP_001373867.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386939.1 NP_001373868.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386940.1 NP_001373869.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386946.1 NP_001373875.1 solute carrier organic anion transporter family member 1A2 isoform 7 precursor
NM_001386947.1 NP_001373876.1 solute carrier organic anion transporter family member 1A2 isoform 2
NM_001386948.1 NP_001373877.1 solute carrier organic anion transporter family member 1A2 isoform 3 precursor
NM_001386949.1 NP_001373878.1 solute carrier organic anion transporter family member 1A2 isoform 2
NM_001386951.1 NP_001373880.1 solute carrier organic anion transporter family member 1A2 isoform 6 precursor
NM_001386952.1 NP_001373881.1 solute carrier organic anion transporter family member 1A2 isoform 3 precursor
NM_001386953.1 NP_001373882.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386954.1 NP_001373883.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386958.1 NP_001373887.1 solute carrier organic anion transporter family member 1A2 isoform 5 precursor
NM_001386959.1 NP_001373888.1 solute carrier organic anion transporter family member 1A2 isoform 9 precursor
NM_001386960.1 NP_001373889.1 solute carrier organic anion transporter family member 1A2 isoform 2
NM_001386961.1 NP_001373890.1 solute carrier organic anion transporter family member 1A2 isoform 13
NM_001386962.1 NP_001373891.1 solute carrier organic anion transporter family member 1A2 isoform 11
NM_001386963.1 NP_001373892.1 solute carrier organic anion transporter family member 1A2 isoform 12
NM_021094.4 NP_066580.1 solute carrier organic anion transporter family member 1A2 isoform 1
NM_134431.5 NP_602307.1 solute carrier organic anion transporter family member 1A2 isoform 1

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables organic anion transmembrane transporter activity IDA
IDA: Inferred from direct assay
10873595 GOA
enables transmembrane transporter activity IDA
IDA: Inferred from direct assay
25132355 GOA
Cellular Component GO Annotation Evidence References Source
located in basal plasma membrane IDA
IDA: Inferred from direct assay
35307651 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
25132355 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLCO1A2 Protein Structure

OATP

OATP: Organic Anion Transporter Polypeptide (OATP) family (20 - 598)

Kazal_2

Kazal_2: Kazal-type serine protease inhibitor domain (445 - 486)

  • 0
  • 200
  • 400
  • 600
  • 670 a.a.
Protein Preferred Names Protein Names

solute carrier organic anion transporter family member 1A2

  • OATP-1

SLCO1A2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P810930 OATP1 Antibody WB, IHC-P Human, Mouse, Rat

Related Diseases

Diseases Alias
Cholestasis

  • Obstruction Of Bile Duct

  • Bile Duct Obstruction

  • Bile Occlusion

  • Extrahepatic Biliary Obstruction

  • Extrahepatic Bile Duct Obstruction

  • Bile Stasis

  • Biliary Stasis

  • Obstructive Hyperbilirubinemia

  • Obstructed Jaundice

  • Bile Duct Obstructed

  • Bile Ductal Obstruction

  • Biliary Duct Obstruction

  • Obstructed Bile Ductal

  • Obstructed Biliary Duct

  • Obstructed Biliary Ductal

  • Jaundice Regurgitation

  • Obstructive Jaundice

  • Cholestatic Jaundice

  • Cholestatic Jaundice Syndrome
Carbapenem Allergy
Intrahepatic Cholestasis

  • Cholestasis, Intrahepatic

  • Neonatal Intrahepatic Cholestasis

  • Cholestasis Intrahepatic

  • Cholestasis Of Pregnancy
Cholelithiasis
Allan-Herndon-Dudley Syndrome

  • AHDS

  • Allan-Herndon Syndrome

  • Monocarboxylate Transporter 8 Deficiency

  • MCT8 DEFICIENCY

  • Mental Retardation, X-Linked, With Hypotonia

  • Triiodothyronine Resistance

  • T3 Resistance

  • Mental Retardation And Muscular Atrophy

  • Mct8-Specific Thyroid Hormone Cell-Membrane Transporter Deficiency

  • Intellectual Disability And Muscular Atrophy

  • Monocarboxylate Transporter-8 Deficiency

  • T3 Resisitence

  • Triiodothyronine Resistence

  • X-Linked Intellectual Disability With Hypotonia

  • Mct8 -Specific Thyroid Hormone Cell Transporter Deficiency

  • Monocarboxylate Transporter 8 Deficiency

  • X-Linked Intellectual Disability-Hypotonia Syndrome
Dubin-Johnson Syndrome

  • DJS

  • Chronic Idiopathic Jaundice

  • Jaundice, Chronic Idiopathic

  • Hyperbilirubinemia, Dubin-Johnson Type

  • Hyperbilirubinemia Ii

  • Hyperbilirubinemia Type 2

  • Conjugated Hyperbilirubinemia

  • Dubin-Sprinz Disease

  • Sprinz-Nelson Syndrome

  • Hblrdj

  • Dubin Johnson Syndrome

  • Hyperbilirubinemia 2

  • Black Liver-Jaundice Syndrome

  • Chronic Idiopathic Jaundice With Pigmented Liver

  • Dubin-Sprinz Syndrome

  • Hyperbilirubinaemia Type 2

  • Djs - [Dubin-Johnson Syndrome]
Cholestasis, Benign Recurrent Intrahepatic, 1

  • Benign Recurrent Intrahepatic Cholestasis

  • BRIC1

  • Summerskill Syndrome

  • Bric

  • Summerskill-Walshe-Tygstrup Syndrome

  • Cholestasis, Benign Recurrent Intrahepatic

  • Benign Recurrent Intrahepatic Cholestasis 1

  • Benign Recurrent Intrahepatic Cholestasis Type 1

  • Bric Type 1

  • Low Gamma-Gt Familial Intrahepatic Cholestasis

  • Recurrent Familial Intrahepatic Cholestasis

  • Cholestasis, Benign Recurrent Intrahepatic 1

  • Mild Atp8b1 Deficiency

  • Recurrent Familial Intrahepatic Cholestasis 1

  • Abcb11-Related Intrahepatic Cholestasis

  • Atp8b1-Related Intrahepatic Cholestasis

  • Cholestasis, Intrahepatic, Recurrent, Benign, Type 1

  • Progressive Intrahepatic Cholestasis

  • Cholestasis, Progressive Familial Intrahepatic 3

  • Bric - [Benign Recurrent Intrahepatic Cholestasis]
Extrahepatic Cholestasis

  • Cholestasis, Extrahepatic

  • Extrahepatic Biliary Stasis

  • Extrahepatic Obstructive Biliary Disease

  • Cholestasis Extrahepatic
Intrahepatic Cholestasis Of Pregnancy

  • Recurrent Intrahepatic Cholestasis Of Pregnancy

  • Gravidic Intrahepatic Cholestasis

  • Pregnancy-Related Cholestasis

  • Icp

  • Pregnancy Related Cholestasis

  • Cholestasis, Intrahepatic Of Pregnancy

  • Familial Intrahepatic Cholestasis Of Pregnancy

  • Familial Recurrent Intrahepatic Cholestasis Of Pregnancy

  • Ricp

  • Obstetric Cholestasis
Bilirubin Metabolic Disorder

  • Hyperbilirubinemia

  • Hereditary Hyperbilirubinemia

  • Hyperbilirubinemia, Hereditary

  • Hyperbilirubinaemia
Gilbert Syndrome

  • Gilbert Disease

  • Gilbert'S Disease

  • Gilbert'S Syndrome

  • Cholemia, Familial

  • Familial Nonhemolytic Jaundice

  • Meulengracht Syndrome

  • Gilbert Syndrome, Susceptibility To

  • Hyperbilirubinemia, Gilbert Type

  • Hblrg

  • Hyperbilirubinemia, Arias Type

  • Hyperbilirubinemia I

  • Constitutional Hyperbilirubinemia

  • Gilbert-Meulengracht Syndrome

  • Hereditary Nonhemolytic Jaundice

  • Hyperbilirubinemia Arias Type

  • Hyperbilirubinemia Type 1

  • Constitutional Liver Dysfunction

  • Gilbert-Lereboullet Syndrome

  • Hyperbilirubinemia 1

  • Unconjugated Benign Bilirubinemia

  • GILBS

  • Gilberts Syndrome

  • Familial Nonhaemolytic Jaundice

  • Constitutional Hyperbilirubinaemia

  • Hereditary Nonhaemolytic Bilirubinaemia

  • Familial Nonhaemolytic Bilirubinaemia

  • Idiopathic Hyperbilirubinaemia

  • Icterus Intermittens Juvenilis

  • Chronic Intermittent Juvenile Jaundice

  • Low-Grade Chronic Hyperbilirubinaemia Syndrome

  • Benign Unconjugated Bilirubinaemia Syndrome

  • Hereditary Nonhaemolytic Jaundice

  • Idiopathic Unconjugated Hyperbilirubinaemia

  • Gilbert--Lereboullet Syndrome

  • Constitutional Hepatic Dysfunction

  • Meulengracht Icterus

  • Cholaemia Familiaris Simplex

  • Familial Cholaemia

  • Congenital Familial Cholaemia

  • Physiologic Cholaemia

  • Hyperbilirubinaemia Type 1

  • Gilbert Cholaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13351 SLCO1A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SLCO1A2 VGNC VGNC:65442
Macaca mulatta SLCO1A2 VGNC VGNC:77601
Canis familiaris SLCO1A2 VGNC VGNC:46493
Bos taurus SLCO1A2 VGNC VGNC:34949
Rattus norvegicus SLCO1A2 RGD RGD:621389
Others SLCO1A2 NCBI