Map3k20 - mitogen-activated protein kinase kinase kinase 20 Gene

Also Known as MRK; Zak; MLTK; HCCS-4; MLTKbeta; MLTKalpha; B230120H23Rik

Species: Mus musculus

Gene Type: protein coding

Gene ID: 65964

Summary

Enables ATP binding activity; MAP kinase kinase kinase activity; and magnesium ion binding activity. Involved in intracellular signal transduction; limb development; and protein phosphorylation. Acts upstream of or within Cytoskeleton organization and embryonic digit morphogenesis. Located in cytoplasm and nucleus. Is expressed in heart; limb; limb bud; and urinary system. Used to study split hand-foot malformation. Human ortholog(s) of this gene implicated in centronuclear myopathy 6 with fiber-type disproportion. Orthologous to human MAP3K20 (mitogen-activated protein kinase kinase kinase 20). [provided by Alliance of Genome Resources, Apr 2022]

Map3k20 Products (3)

mRNA	Protein	Name
NM_001164791.2	NP_001158263.1	mitogen-activated protein kinase kinase kinase 20 isoform 3
NM_023057.6	NP_075544.1	mitogen-activated protein kinase kinase kinase 20 isoform 1
NM_178084.5	NP_835185.2	mitogen-activated protein kinase kinase kinase 20 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	11042189	MGI
enables MAP kinase kinase kinase activity	IDA IDA: Inferred from direct assay	11042189	MGI
enables magnesium ion binding	IDA IDA: Inferred from direct assay	11042189	MGI
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	11042189	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in JNK cascade	IMP IMP: Inferred from mutant phenotype	27598200	MGI
acts upstream of or within cytoskeleton organization	IDA IDA: Inferred from direct assay	11042189	MGI
involved in embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	26755636	MGI
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	11042189	MGI
involved in limb development	IMP IMP: Inferred from mutant phenotype	26755636	MGI
involved in p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	27598200	MGI
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	11042189	MGI
involved in stress-activated MAPK cascade	IMP IMP: Inferred from mutant phenotype	32289254	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11042189	MGI
located in nucleus	IDA IDA: Inferred from direct assay	11042189	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
mitogen-activated protein kinase kinase kinase 20	MLK-like mitogen-activated protein triple kinase MLK-related kinase human cervical cancer suppressor gene 4 protein leucine zipper- and sterile alpha motif kinase ZAK leucine zipper- and sterile alpha motif-containing kinase mitogen-activated protein

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148061	DB1113		99.86%	Unkown
HY-148063	DB0614		96.07%	Unkown
HY-RS08055	MAP3K20 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map3k20	NCBI	NCBI:51776