Diablo - diablo, IAP-binding mitochondrial protein Gene

Also Known as Smac; 0610041G12Rik; 1700006L01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 66593

Summary

Involved in positive regulation of apoptotic process. Acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c; intrinsic apoptotic signaling pathway in response to oxidative stress; and neuron apoptotic process. Located in cytoplasmic side of plasma membrane and mitochondrion. Part of CD40 receptor complex. Is expressed in several structures, including cochlea; early conceptus; ganglia; pancreas epithelium; and trigeminal nerve. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 64. Orthologous to human DIABLO (diablo IAP-binding mitochondrial protein). [provided by Alliance of Genome Resources, Apr 2022]

Diablo Products (1)

mRNA Protein Name
NM_023232.3 NP_075721.3 diablo IAP-binding mitochondrial protein precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23479728 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: Inferred from direct assay
12011074 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: Inferred from mutant phenotype
16085184 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c IDA
IDA: Inferred from direct assay
14623868 MGI
acts upstream of or within intrinsic apoptotic signaling pathway in response to oxidative stress IDA
IDA: Inferred from direct assay
16085184 MGI
acts upstream of or within neuron apoptotic process IDA
IDA: Inferred from direct assay
14623868 MGI
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
11604410 MGI
Cellular Component GO Annotation Evidence References Source
part of CD40 receptor complex IDA
IDA: Inferred from direct assay
20614026 MGI
located in cytoplasm IDA
IDA: Inferred from direct assay
15882989 MGI
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
20614026 MGI
located in mitochondrion IDA
IDA: Inferred from direct assay
14623868 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

diablo IAP-binding mitochondrial protein

diablo homolog, mitochondrial

  • direct IAP binding protein with low PI

  • direct IAP-binding protein with low pI

  • second mitochondria-derived activator of caspase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W008235 Fmoc-N-Me-Ala-OH 99.92% Unkown
HY-RS03762 DIABLO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19505 Diablo Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25999 Diablo Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Diablo NCBI NCBI:56616