Smc6 - structural maintenance of chromosomes 6 Gene

Also Known as SMC-6; Smc6l1; mKIAA4103; 2810489L22Rik; 3830418C19Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 67241

Summary

Predicted to enable damaged DNA binding activity; single-stranded DNA binding activity; and ubiquitin protein Ligase binding activity. Predicted to be involved in DNA recombination; cellular senescence; and positive regulation of chromosome segregation. Predicted to act upstream of or within DNA recombination and DNA repair. Located in chromosome; mitotic spindle pole; and nucleus. Part of Smc5-Smc6 complex. Is expressed in central nervous system; embryo; retina; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human SMC6 (structural maintenance of chromosomes 6). [provided by Alliance of Genome Resources, Apr 2022]

Smc6 Products (3)

mRNA Protein Name
NM_001324476.1 NP_001311405.1 structural maintenance of chromosomes protein 6 isoform 2
NM_001361252.1 NP_001348181.1 structural maintenance of chromosomes protein 6 isoform 3
NM_025695.4 NP_079971.2 structural maintenance of chromosomes protein 6 isoform 1

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
part of Smc5-Smc6 complex IDA
IDA: Inferred from direct assay
26919979 MGI
located in chromosome, centromeric region IDA
IDA: Inferred from direct assay
26919979 MGI
located in mitotic spindle pole IDA
IDA: Inferred from direct assay
26919979 MGI
located in nucleus IDA
IDA: Inferred from direct assay
26919979 MGI
located in sex chromosome IDA
IDA: Inferred from direct assay
11408570 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

structural maintenance of chromosomes protein 6

  • SMC protein 6

  • SMC6 structural maintenance of chromosomes 6-like 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13422 SMC6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Smc6 NCBI NCBI:79677