SRPRA - SRP receptor subunit alpha Gene

Homo sapiens

Also known as DP; SRPR; Sralpha

Gene ID: 6734 | Gene type: protein coding

About SRPRA

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:126,235,930-126,268,895 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 41.3), salivary gland (RPKM 33.7) and 25 other tissues.

Summary

The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

SRPRA Products(2)

mRNA	Protein	Name
NM_001177842.2	NP_001171313.1	signal recognition particle receptor subunit alpha isoform 2
NM_003139.4	NP_003130.2	signal recognition particle receptor subunit alpha isoform 1

SRPRA Protein Structure

SRP-alpha_N

SRP54_N

SRP54

0
100
200
300
400
500
600
638 a.a.

Protein Preferred Names

Protein Names

signal recognition particle receptor subunit alpha

DP-alpha

Related Diseases

Diseases

Alias

Shwachman-Diamond Syndrome 1

Shwachman-Diamond Syndrome	Shwachman Syndrome
Shwachman-Bodian-Diamond Syndrome	Sds
Pancreatic Insufficiency And Bone Marrow Dysfunction	Shwachman-Bodian Syndrome
SDS1	Lipomatosis Of Pancreas, Congenital
Congenital Lipomatosis Of Pancreas	Shwachman-Diamond Type Metaphyseal Dysplasia
Metaphyseal Chondrodysplasia, Shwachman Type	Shwachman-Diamond-Oski Syndrome

Severe Congenital Neutropenia

Congenital Neutropenia	Neutropenia, Severe Congenital
Congenital Agranulocytosis	Infantile Genetic Agranulocytosis
Kostmann Disease	Kostmann'S Agranulocytosis
Kostmann'S Syndrome	Severe Infantile Genetic Neutropenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13780	SRPRA Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SRPRA	VGNC	VGNC:77885
Canis familiaris	SRPRA	VGNC	VGNC:53450
Rattus norvegicus	SRPRA	RGD	RGD:1311504
Mus musculus	SRPRA	MGD	MGI:1914648
Bos taurus	SRPRA	VGNC	VGNC:56282
Felis catus	SRPRA	VGNC	VGNC:104332

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