SRPRA - SRP receptor subunit alpha Gene

Also Known as DP; SRPR; Sralpha

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6734

About SRPRA

Cytogenetic location: 11q24.2 Genomic coordinates (GRCh38): 11:126,235,930-126,268,895 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 1 paralogue. Ubiquitous expression in thyroid (RPKM 41.3), salivary gland (RPKM 33.7) and 25 other tissues.

Summary

The gene encodes a subunit of the endoplasmic reticulum signal recognition particle receptor that, in conjunction with the signal recognition particle, is involved in the targeting and translocation of signal sequence tagged secretory and membrane proteins across the endoplasmic reticulum. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]

SRPRA Products (2)

mRNA	Protein	Name
NM_001177842.2	NP_001171313.1	signal recognition particle receptor subunit alpha isoform 2
NM_003139.4	NP_003130.2	signal recognition particle receptor subunit alpha isoform 1

Gene Ontology

Cellular Component

Cellular Component GO Annotation	Evidence	References	Source
located in membrane	IDA IDA: Inferred from direct assay	22375059	GOA
part of signal recognition particle receptor complex	EXP EXP: Inferred from Experiment	16439358	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SRPRA Protein Structure

SRP-alpha_N

SRP54_N

SRP54

0
100
200
300
400
500
600
638 a.a.

Protein Preferred Names	Protein Names
signal recognition particle receptor subunit alpha	DP-alpha

Related Diseases

Diseases	Alias
Shwachman-Diamond Syndrome 1	Shwachman-Diamond Syndrome Shwachman Syndrome Shwachman-Bodian-Diamond Syndrome Sds Pancreatic Insufficiency And Bone Marrow Dysfunction Shwachman-Bodian Syndrome SDS1 Lipomatosis Of Pancreas, Congenital Congenital Lipomatosis Of Pancreas Shwachman-Diamond Type Metaphyseal Dysplasia Metaphyseal Chondrodysplasia, Shwachman Type Shwachman-Diamond-Oski Syndrome
Severe Congenital Neutropenia	Congenital Neutropenia Neutropenia, Severe Congenital Congenital Agranulocytosis Infantile Genetic Agranulocytosis Kostmann Disease Kostmann'S Agranulocytosis Kostmann'S Syndrome Severe Infantile Genetic Neutropenia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13780	SRPRA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SRPRA	VGNC	VGNC:77885
Canis familiaris	SRPRA	VGNC	VGNC:53450
Rattus norvegicus	SRPRA	RGD	RGD:1311504
Mus musculus	SRPRA	MGD	MGI:1914648
Bos taurus	SRPRA	VGNC	VGNC:56282
Felis catus	SRPRA	VGNC	VGNC:104332