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SSR3 - signal sequence receptor subunit 3 Gene

Also Known as TRAPG

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6747

About SSR3

Cytogenetic location: 3q25.31 Genomic coordinates (GRCh38): 3:156,539,553-156,555,117 (from NCBI)

This gene has 9 transcripts (splice variants) and 223 orthologues. Ubiquitous expression in thyroid (RPKM 48.0), endometrium (RPKM 38.4) and 25 other tissues.

Summary

The signal sequence receptor (SSR) is a glycosylated endoplasmic reticulum (ER) membrane receptor associated with protein translocation across the ER membrane. The SSR is comprised of four membrane proteins/subunits: alpha, beta, gamma, and delta. The first two are glycosylated subunits and the latter two are non-glycosylated subunits. This gene encodes the gamma subunit, which is predicted to span the membrane four times. [provided by RefSeq, Aug 2010]

SSR3 Products (4)

mRNA	Protein	Name
NM_001308197.2	NP_001295126.1	translocon-associated protein subunit gamma isoform 1
NM_001308204.2	NP_001295133.1	translocon-associated protein subunit gamma isoform 3
NM_001308205.2	NP_001295134.1	translocon-associated protein subunit gamma isoform 3
NM_007107.5	NP_009038.1	translocon-associated protein subunit gamma isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SSR3 Protein Structure

TRAP-gamma

0
100
185 a.a.

Protein Preferred Names	Protein Names
translocon-associated protein subunit gamma	SSR gamma

Related Diseases

Diseases	Alias
Congenital Disorder Of Glycosylation, Type In	Congenital Disorder Of Glycosylation CDG1N Congenital Disorders Of Glycosylation Cdg In Cdgin Congenital Disorder Of Glycosylation 1n Carbohydrate-Deficient Glycoprotein Syndrome Cdg Rft1-Cdg Cdg-In Congenital Disorder Of Glycosylation Type In Carbohydrate Deficient Glycoprotein Syndrome Cdg Syndrome Congenital Disorder Of Glycosylation In Carbohydrate-Deficient Glycoprotein Syndromes Cdg Syndrome Type In Carbohydrate Deficient Glycoprotein Syndrome Type In Congenital Disorder Of Glycosylation Type 1n Man5glcnac2-Pp-Dol Flippase Deficiency Glycosylation, Congenital Disorder Of Glycosylation, Congenital Disorder Of, Type In
Tylosis With Esophageal Cancer	Palmoplantar Keratoderma-Esophageal Carcinoma Syndrome TOC Keratosis Palmaris Et Plantaris With Esophageal Cancer Bennion-Patterson Syndrome Howell-Evans Syndrome Keratosis Palmoplantaris-Esophageal Carcinoma Syndrome Palmoplantar Hyperkeratosis-Esophageal Carcinoma Syndrome Tylosis-Oesophageal Carcinoma Syndrome Palmoplantar Keratoderma With Esophageal Cancer Howel-Evans Syndrome Keratosis Palmoplantaris With Esophageal Cancer Tylosis - Oesophageal Carcinoma Howel-Evans' Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13816	SSR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SSR3	VGNC	VGNC:46839
Felis catus	SSR3	VGNC	VGNC:97645
Bos taurus	SSR3	VGNC	VGNC:35321
Mus musculus	SSR3	MGD	MGI:1914687
Rattus norvegicus	SSR3	RGD	RGD:621630
Macaca mulatta	SSR3	VGNC	VGNC:82769
Others	SSR3	NCBI