XCL2 - X-C motif chemokine ligand 2 Gene

Also Known as SCM1B; SCYC2; SCM-1b

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6846

About XCL2

Cytogenetic location: 1q24.2 Genomic coordinates (GRCh38): 1:168,540,768-168,543,997 (from NCBI)

This gene has 1 transcript (splice variant), 117 orthologues and 25 paralogues. Broad expression in spleen (RPKM 4.0), bone marrow (RPKM 3.8) and 18 other tissues.

Summary

Predicted to enable CCR Chemokine Receptor binding activity and chemokine activity. Predicted to be involved in several processes, including cellular response to cytokine stimulus; leukocyte chemotaxis; and positive regulation of T cell chemotaxis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

XCL2 Products (1)

mRNA Protein Name
NM_003175.4 NP_003166.1 cytokine SCM-1 beta precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XCL2 Protein Structure

IL8

IL8: Small cytokines (intecrine/chemokine), interleukin-8 like (31 - 83)

  • 0
  • 100
  • 114 a.a.
Protein Preferred Names Protein Names

cytokine SCM-1 beta

  • XC chemokine ligand 2

XCL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
XCL2 Q9UBD3 KRTAP10-9 Homo sapiens P60411
Validated Y2H
25416956
Intra
XCL2 Q9UBD3 KRTAP10-9 Homo sapiens P60411
Y2H Array
25416956
Intra
XCL2 Q9UBD3 KRTAP10-9 Homo sapiens P60411
Y2H Prey Pooling
25416956
Intra
XCL2 Q9UBD3 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
XCL2 Q9UBD3 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
XCL2 Q9UBD3 CCL5 Homo sapiens P13501
SPR
28381538
Intra
XCL2 Q9UBD3 CXCL12 Homo sapiens P48061
SPR
28381538
Intra
XCL2 Q9UBD3 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra
XCL2 Q9UBD3 NOTCH2NLA Homo sapiens Q7Z3S9
Validated Y2H
25416956
Intra
XCL2 Q9UBD3 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant XCL2 Proteins

Cat. No. Product Name Accession Purity
HY-P74461 XCL2/SCM-1 beta Protein, Human (sf9, His) Q9UBD3 (M1-G114) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Recombinase Activating Gene 1 Deficiency
Combined Cellular And Humoral Immune Defects With Granulomas

  • Combined Immunodeficiency With Skin Granulomas

  • CCHIDG

  • Cid Due To Rag 1/2 Deficiency

  • Combined Immunodeficiency Due To Rag 1/2 Deficiency

  • Combined Immunodeficiency With Granulomatosis

  • CHIDG

  • Immune Defects, Combined Cellular And Humoral With Granulomas
Photokeratitis
Immunodeficiency 44

  • IMD44
Cataract 44

  • CTRCT44

  • Total Early-Onset Cataract

  • Cataract 44 And Hypotrichosis

  • Cataract And Hypotrichosis

  • Cataract, Type 44
Bardet-Biedl Syndrome 1

  • BBS1

  • Bardet-Biedl Syndrome 1, Modifier Of

  • Bardet-Biedl Syndrome

  • BBS

  • Bardet-Biedl Syndrome, Type 1

  • Laurence-Moon-Bardet-Biedl Syndrome
Iminoglycinuria

  • Iminoglycinuria, Digenic

  • IG
Leber Plus Disease

  • Leber Congenital Amaurosis

  • Lca

  • Leber'S Amaurosis

  • Leber'S Disease

  • Amaurosis Congenita Of Leber

  • Amaurosis Congenita Of Leber, Type 1

  • Lhon Plus Disease

  • Congenital Absence Of The Rods And Cones

  • Congenital Retinal Blindness

  • Crb

  • Congenital Amaurosis Of Retinal Origin

  • Leber'S Congenital Amaurosis

  • Leber Congenital Amaurosis 1

  • Leber'S Congenital Tapetoretinal Degeneration

  • Leber'S Congenital Tapetoretinal Dysplasia

  • Lca1

  • Leber Congenital Amaurosis Type 1

  • Retinal Blindness, Congenital

  • Amaurosis, Leber Congenital

  • Dysgenesis Neuroepithelialis Retinae

  • Hereditary Epithelial Dysplasia Of Retina

  • Hereditary Retinal Aplasia

  • Heredoretinopathia Congenitalis

  • Leber Abiotrophy

  • Leber Congenital Tapetoretinal Degeneration

  • Lebers Congenital Amaurosis

  • Optic Atrophy, Hereditary, Leber
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15867 XCL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus XCL2 MGD MGI:104593