Mllt3 - myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3 Gene

Also Known as Af9; D4Ertd321e; 2210011H10Rik; 2610012I03Rik; 3830408D16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70122

Summary

Predicted to enable chromatin binding activity and lysine-acetylated histone binding activity. Acts upstream of or within anterior/posterior pattern specification; gene expression; and segment specification. Located in nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and limb bud. Orthologous to human MLLT3 (MLLT3 super elongation complex subunit). [provided by Alliance of Genome Resources, Apr 2022]

Mllt3 Products (7)

mRNA Protein Name
NM_001286158.2 NP_001273087.1 protein AF-9 isoform 3
NM_001404955.1 NP_001391884.1 protein AF-9 isoform 4
NM_001404956.1 NP_001391885.1 protein AF-9 isoform 5
NM_001404957.1 NP_001391886.1 protein AF-9 isoform 6
NM_001404958.1 NP_001391887.1 protein AF-9 isoform 7
NM_027326.4 NP_081602.3 protein AF-9 isoform 1
NM_029931.4 NP_084207.2 protein AF-9 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12776190 MGI
Biological Process GO Annotation Evidence References Source
acts upstream of or within anterior/posterior pattern specification IMP
IMP: Inferred from mutant phenotype
12242306 MGI
acts upstream of or within gene expression IDA
IDA: Inferred from direct assay
20427473 MGI
acts upstream of or within gene expression IMP
IMP: Inferred from mutant phenotype
20427473 MGI
acts upstream of or within segment specification IMP
IMP: Inferred from mutant phenotype
12242306 MGI
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
20427473 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein AF-9

  • myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog

  • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)

  • translocated to, 3

  • myeloid/lymphoid or mixed-lineage leukemia translocated to chromosome 3 protein homolog

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-W105310A Croconic acid disodium 99.98% Unkown
HY-112804 SGC-iMLLT Inhibitor 99.33% Unkown
HY-155412 PFI-6 99.91% Unkown
HY-181834 PROTAC MLLT1 Degrader-1 Degrader / Unkown
HY-RS08496 MLLT3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mllt3 NCBI NCBI:4300