Mutyh - mutY DNA glycosylase Gene

Also Known as Myh; Mutyha; Mutyhb; Mutyhc; Mutyhbeta; Mutyhalpha; 5730495A01Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 70603

Summary

Predicted to enable DNA N-glycosylase activity; DNA binding activity; and MutSalpha complex binding activity. Involved in negative regulation of necroptotic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in familial adenomatous polyposis; familial adenomatous polyposis 2; and stomach carcinoma. Orthologous to human MUTYH (mutY DNA glycosylase). [provided by Alliance of Genome Resources, Apr 2022]

Mutyh Products (3)

mRNA Protein Name
NM_001159581.1 NP_001153053.1 adenine DNA glycosylase isoform a
NM_001316747.1 NP_001303676.1 adenine DNA glycosylase isoform b
NM_133250.2 NP_573513.2 adenine DNA glycosylase isoform a

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in negative regulation of necroptotic process IMP
IMP: Inferred from mutant phenotype
28059467 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

adenine DNA glycosylase

  • a/G-specific adenine DNA glycosylase

  • mMYH

  • mutY homolog alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08854 MUTYH Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22658 Mutyh Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29172 Mutyh Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mutyh NCBI NCBI:4595