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TNS1 - tensin 1 Gene

Also Known as TNS; MXRA6; MST091; MST122; MST127; MSTP091; MSTP122; MSTP127; PPP1R155

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7145

About TNS1

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:217,799,791-218,033,982 (from NCBI)

This gene has 24 transcripts (splice variants), 222 orthologues and 6 paralogues. Broad expression in fat (RPKM 95.5), lung (RPKM 38.8) and 21 other tissues.

Summary

The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

TNS1 Products (4)

mRNA	Protein	Name
NM_001308022.2	NP_001294951.1	tensin-1 isoform 2
NM_001308023.2	NP_001294952.1	tensin-1 isoform 3
NM_001387777.1	NP_001374706.1	tensin-1 isoform 4
NM_022648.7	NP_072174.3	tensin-1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17190795	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in focal adhesion	IDA IDA: Inferred from direct assay	11023826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TNS1 Protein Structure

PTEN_C2

SH2

PTB

0
300
600
900
1200
1500
1735 a.a.

Protein Preferred Names	Protein Names
tensin-1	Matrix-remodelling-associated protein 6

TNS1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TNS1	Q9HBL0	MET	Homo sapiens	P08581	FPS	24728074
Intra	TNS1	Q9HBL0	KIT	Homo sapiens	P10721	FPS	24728074
Intra	TNS1	Q9HBL0	AR	Homo sapiens	P10275	FPS	24728074

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Gastric Fundus Cancer	Gastric Fundus Carcinoma Ca Fundus - Stomach Malignant Neoplasm Of Fundus Of Stomach Malignant Tumor Of Fundus Of Stomach Cancer Of Fundus Of Stomach Carcinoma Of Fundus Of Stomach Malignant Neoplasm Of Gastric Fundus
Cowden Syndrome 1	Bannayan-Riley-Ruvalcaba Syndrome Pten Hamartoma Tumor Syndrome Lhermitte-Duclos Disease Bannayan-Zonana Syndrome Phts Riley-Smith Syndrome Bzs Ruvalcaba-Myhre-Smith Syndrome Multiple Hamartoma Syndrome Rmss Brrs Dysplastic Gangliocytoma Of The Cerebellum CWS1 Cs Cd Mham Pten Hamartoma Tumor Syndrome With Granular Cell Tumor Macrocephaly Multiple Lipomas And Hemangiomata Bannayan-Ruvalcaba-Riley Syndrome Myhre-Riley-Smith Syndrome LDD Cerebelloparenchymal Disorder Vi Hamartoma Syndrome, Multiple Bbrs Macrocephaly, Pseudopapilledema, And Multiple Hemangiomata Macrocephaly, Multiple Lipomas, And Hemangiomata Macrocephaly Pseudopapilledema And Multiple Hemangiomas Ruvalcaba -Myhre-Smith Syndrome Ruvalcaba-Myhre Syndrome Cowden Disease Macrocephaly Pseudopapilledema And Multiple Hemangiomata Cerebellar Granule Cell Hypertrophy And Megalencephaly Cpd6 Pten Hamartoma Tumor Syndromes Cowden Syndrome, Type 1
Orthostatic Intolerance	Mitral Valve Prolapse Neurocirculatory Asthenia Mitral Valve Prolapse Syndrome Irritable Heart Systolic Click-Murmur Syndrome Soldiers Heart Cardiovascular Malfunction Arising From Mental Factors Cardiovascular Neurosis Da Costa'S Syndrome Krishaber'S Disease Barlow'S Syndrome Floppy Mitral Valve Mitral Leaflet Syndrome Myxomatous Mitral Valve Prolapse Postural Orthostatic Tachycardia Syndrome Due To Net Deficiency Familial Orthostatic Tachycardia Due To Norepinephrine Transporter Deficiency Orthostatic Intolerance Due To Net Deficiency Pots Due To Net Deficiency OI Intolerance, Orthostatic Mitral Valve Prolapse, Familial, X-Linked Ballooning Mitral Valve Barlow Syndrome Flail Mitral Leaflet Myxomatous Mitral Valve Mitral Valve Prolapse-Click Syndrome Prolapsing Mitral Valve Leaflet Syndrome Billowing Mitral Valve Leaflet Posterior Mitral Leaflet Deformity Ballooning Posterior Leaflet Syndrome Blue Valve Syndrome Floppy Mitral Valve Syndrome Mitral Valvular Prolapse Systolic Click Syndrome
Cowden Syndrome	Cowden Disease Multiple Hamartoma Syndrome Cowden'S Disease Lhermitte-Duclos Disease Cd Cs Mham Dysplastic Gangliocytoma Of Cerebellum Cowden'S Syndrome Hamartoma Syndrome, Multiple

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14867	TNS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19524	Pycard Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21447	Tns1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27965	Tns1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TNS1	RGD	RGD:68427
Mus musculus	TNS1	MGD	MGI:104552
Macaca mulatta	TNS1	VGNC	VGNC:78414
Canis familiaris	TNS1	VGNC	VGNC:47701
Felis catus	TNS1	VGNC	VGNC:66435
Bos taurus	TNS1	VGNC	VGNC:36207
Others	TNS1	NCBI