ACTG2 - actin gamma 2, smooth muscle Gene

Also Known as ACT; ACTE; VSCM; ACTA3; ACTL3; ACTSG; VSCM1; MMIHS5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 72

About ACTG2

Cytogenetic location: 2p13.1 Genomic coordinates (GRCh38): 2:73,893,008-73,919,865 (from NCBI)

This gene has 9 transcripts (splice variants), 120 orthologues, 26 paralogues and is associated with 5 phenotypes. Biased expression in prostate (RPKM 1093.2), urinary bladder (RPKM 1063.1) and 7 other tissues.

Summary

Actins are highly conserved proteins that are involved in various types of cell motility and in the maintenance of the Cytoskeleton. Three types of actins, alpha, beta and gamma, have been identified in vertebrates. Alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the Cytoskeleton and as mediators of internal cell motility. This gene encodes actin gamma 2; a smooth muscle actin found in enteric tissues. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Based on similarity to peptide cleavage of related actins, the mature protein of this gene is formed by removal of two N-terminal peptides.[provided by RefSeq, Dec 2010]

ACTG2 Products (2)

mRNA	Protein	Name
NM_001199893.2	NP_001186822.1	actin, gamma-enteric smooth muscle isoform 2 precursor
NM_001615.4	NP_001606.1	actin, gamma-enteric smooth muscle isoform 1 precursor

ACTG2 Protein Structure

Actin

0
100
200
300
376 a.a.

Protein Preferred Names	Protein Names
actin, gamma-enteric smooth muscle	actin, gamma 2, smooth muscle, enteric

ACTG2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P85827	Actin smooth muscle (SMA) Antibody (YA5519)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat
HY-P85828	Actin Muscle Specific Antibody (YA5520)	IHC-P, WB, ICC/IF, ELISA	Human, Mouse, Rat, Monkey, Bovin, Pig, Chick

Related Diseases

Diseases	Alias
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 5	MMIHS5
Visceral Myopathy 1	Visceral Myopathy Megaduodenum And/Or Megacystis VSCM1 Pseudoobstruction, Idiopathic Intestinal Vscm Pseudoobstruction Idiopathic Intestinal Visceral Myopathy Familial Berdon Syndrome Idiopathic Intestinal Pseudoobstruction Infantile Visceral Myopathy Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome Mmih Megacystis Microcolon Intestinal Hypoperistalsis Syndrome Intestinal Pseudo-Obstruction Visceral Neuropathy, Familial, Autosomal Dominant
Intestinal Pseudo-Obstruction	Chronic Intestinal Pseudoobstruction Chronic Intestinal Pseudo-Obstruction Cipo Neuronal Intestinal Dysplasia Hollow Visceral Myopathy Familial Visceral Neuropathy Paralytic Ileus Intestinal Pseudoobstruction Chronic Idiopathic Intestinal Pseudo-Obstruction Ciip Congenital Short Bowel Syndrome Enteric Neuropathy Familial Visceral Myopathy Ipo Pseudo-Obstruction Of Intestine Pseudointestinal Obstruction Syndrome Pseudoobstructive Syndrome Congenital Idiopathic Intestinal Pseudoobstruction Visceral Myopathy, Familial
Autosomal Dominant Familial Visceral Neuropathy	Visceral Neuropathy, Familial, Autosomal Dominant
Visceral Neuropathy, Familial, 3, Autosomal Dominant	VSCN3 Enteric Neuropathy, Familial Pseudoobstruction, Chronic Intestinal, Neuropathic Pseudoobstruction, Idiopathic Intestinal
Actg2 Visceral Myopathy	Familial Visceral Myopathy Berdon Syndrome Familial Hollow Visceral Myopathy Hereditary Hollow Visceral Myopathy Megaduodenum And/Or Megacystis
Myopathic Intestinal Pseudoobstruction
Hyperinsulinism	Hyperinsulinemia
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1	Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome Berdon Syndrome MMIHS Megacystis Microcolon Intestinal Hypoperistalsis Syndrome Megacystis, Microcolon, Hypoperistalsis Syndrome Visceral Myopathy Mmih Syndrome Megacystis-Microcolon-Intestinal Hypoperistalsis-Hydronephrosis Syndrome MMIHS1 Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome, Mmih Mmhs
Intestinal Obstruction	Inspissated Milk Syndrome Milk Curd Syndrome
Microcolon
Csf1r-Related Brain Malformation And Osteopetrosis	Osteoporosis And Infantile Neuroaxonal Dystrophy
Breast Myoepithelial Carcinoma
Hydronephrosis	Stricture Of Ureteropelvic Junction With Hydronephrosis Hydronephrosis With Ureteral Stricture, Not Elsewhere Classified
Papillary Hidradenoma	Tubular Sweat Gland Adenomas
Prune Belly Syndrome	Eagle-Barrett Syndrome Abdominal Muscle Deficiency Syndrome PBS Abdominal Muscles, Absence Of, With Urinary Tract Abnormality And Cryptorchidism Egbrs Eagle-Barret Syndrome Urethral Obstruction Sequence Obrinsky Syndrome Triad Syndrome Obrisnksy Syndrome Euos Early Urethral Obstruction Sequence Renal Dysplasia Or Hydronephrosis, Oligohydramnios And Subsequent Lung Hypoplasia Due To Urethral Obstruction Absence Of Abdominal Muscles With Urinary Tract Abnormality And Cryptorchidism Abdomen Muscle Deficiency Syndrome Abdomen Muscular Deficiency Syndrome Abdominal Muscular Deficiency Syndrome Abdominal Muscle Aplasia Syndrome
Myopathy	Muscular Diseases Myopathies
Skin Amelanotic Melanoma	Skin Amelanotic Malignant Melanoma Amelanotic Skin Melanoma
Urofacial Syndrome 1	Urofacial Syndrome Ochoa Syndrome Hydronephrosis With Peculiar Facial Expression Ufs Inverted Smile And Occult Neuropathic Bladder Partial Facial Palsy With Urinary Abnormalities UFS1 Urofacial Ochoa'S Syndrome Urofacial Syndrome Type 1 Facial Palsy, Partial, With Urinary Abnormalities Hydronephrosis-Inverted Smile Inverted Smile-Neurogenic Bladder Hydronephrosis-Inverted Smile Syndrome Inverted Smile-Neurogenic Bladder Syndrome Partial Facial Palsy Partial With Urinary Abnormalities Urologic Diseases
Hirschsprung Disease 1	Hirschsprung Disease Aganglionic Megacolon Hscr Hirschsprung'S Disease Congenital Megacolon Congenital Intestinal Aganglionosis Colonic Aganglionosis Hirschsprung Disease, Susceptibility To, 1 Hirschsprung Disease, Protection Against HSCR1 Mgc Pelvirectal Achalasia Total Intestinal Aganglionosis Megacolon, Aganglionic Macrocolon Hscr 1 Hirschsprung Disease Type 1 Hirschsprung Disease, Type 1 Congenital Dilatation Of Colon Aganglionosis Congenital Aganglionic Megacolon Aganglionosis Of Colon Bowel Aganglionosis Colon Aganglionosis Hirschsprung Megacolon
Aortic Aneurysm, Familial Thoracic 1	Thoracic Aortic Aneurysm Annuloaortic Ectasia Familial Thoracic Aortic Aneurysm And Aortic Dissection Familial Aortic Dissection Familial Taad Familial Thoracic Aortic Aneurysm Congenital Aneurysm Of Ascending Aorta Familial Aortic Aneurysm Familial Thoracic Aortic Aneurysm And Dissection Aortic Aneurysm, Thoracic AAT1 Faa1 Aortic Dissection, Familial Aortic Aneurysm, Familial Thoracic Aneurysm, Thoracic Aortic Faa Ftaad Taa Taad Cystic Medial Necrosis Of Aorta Familial Non-Syndromic Thoracic Aortic Aneurysm And Aortic Dissection Aortic Aneurysm Thoracic Familial Aortic Aneurysms Aneurysm, Aortic, Thoracic, Familial, Type 1 Aneurysm Of Thoracic Aorta Intrathoracic Aneurysm Thoracic Aorta Aneurysm Thoracic Aortic Aneurysm Without Rupture Thoracic Aneurysm Thorax Arterial Aneurysm Thoracic Artery Aneurysm Thoracic Arterial Aneurysm Thorax Aneurysm Thorax Aortic Aneurysm Dissection Of Thoracic Aorta

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00219	ACTG2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21471	Actg2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27989	Actg2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ACTG2	RGD	RGD:2027
Felis catus	ACTG2	VGNC	VGNC:59544
Canis familiaris	ACTG2	VGNC	VGNC:37541
Mus musculus	ACTG2	MGD	MGI:104589
Macaca mulatta	ACTG2	VGNC	VGNC:69397
Bos taurus	ACTG2	VGNC	VGNC:59201
Others	ACTG2	NCBI