XPNPEP2 - X-prolyl aminopeptidase 2 Gene

Homo sapiens

Also known as APP2; AEACEI

Gene ID: 7512 | Gene type: protein coding

About XPNPEP2

Cytogenetic location: Xq26.1 Genomic coordinates (GRCh38): X:129,738,979-129,769,536 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues, 7 paralogues and is associated with 2 phenotypes. Biased expression in small intestine (RPKM 88.3), kidney (RPKM 85.4) and 1 other tissue.

Summary

Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several collagen degradation products, neuropeptides, vasoactive Peptides, and cytokines. Structurally, the Enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this Enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008]

XPNPEP2 Products(1)

mRNA	Protein	Name
NM_003399.6	NP_003390.4	xaa-Pro aminopeptidase 2 precursor

XPNPEP2 Protein Structure

Creatinase_N

Peptidase_M24

0
200
400
600
674 a.a.

Protein Preferred Names

Protein Names

xaa-Pro aminopeptidase 2

X-Pro aminopeptidase 2

Recombinant XPNPEP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7499	Aminopeptidase P2 Protein, Human (HEK293, His)	O43895 (H22-A650)	≥95%

Related Diseases

Diseases

Alias

Angioedema Induced By Ace Inhibitors

AEACEI	Angioedema Induced By Ace Inhibitors, Susceptibility To
Susceptibility To Angioedema Induced By Ace Inhibitors	Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioedema
Ace Inhibitor-Related Acquired Angioedema	Acei-Related Acquired Angioedema
Acquired Angioedema With Normal C1 Inhibitor	Acquired Angioedema With Normal C1inh
Raas-Blocker-Induced Angioedema	Raas-Blocker-Induced Angioneurotic Edema
Rae	Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioneurotic Edema
Ae-Acei	Acquired Angioedema

Angioedema

Angioneurotic Oedema	Quincke'S Edema
Angioneurotic Edema	Giant Urticaria

Hereditary Angioedema

Hereditary Angioneurotic Edema	Hereditary Angioedema Type 1
Hane	Angioedema, Hereditary
Hae	Angioedemas, Hereditary
Deficiency Of C1 Esterase Inhibitor	C1 Esterase Inhibitor Deficiency
C1 Inhibitor Deficiency	Familial Angioneurotic Edema
Hereditary Bradykinine-Induced Angioedema	Hereditary Non Histamine-Induced Angioedema
Hae 1	Hae-I
Hereditary Angioneurotic Edema Type 1	Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor
Hereditary Angioedema Types I And Ii	Hereditary Angioneurotic Oedema
Familial Angioedema	Hae - [Hereditary Angioneurotic Oedema]
Bannister Disease, Hereditary	Quincke Disease Or Oedema
Hereditary Quincke Oedema

Pleuropneumonia

Epilepsy, Familial Temporal Lobe, 2

Familial Temporal Lobe Epilepsy 2	Temporal Epilepsy, Familial
ETL2	Ftle
Epilepsy, Familial Temporal Lobe	Familial Temporal Lobe Epilepsy

Nivelon-Nivelon-Mabille Syndrome

Chondrodysplasia-Pseudohermaphroditism Syndrome	NNMS
Chondrodysplasia-Disorder Of Sex Development Syndrome	Nivelon Nivelon Mabille Syndrome

Atrophic Rhinitis

Rhinitis, Atrophic	Ozena
Rhinitis Sicca	Dry Rhinitis
Ozaena

Iminoglycinuria

Iminoglycinuria, Digenic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15887	XPNPEP2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	XPNPEP2	VGNC	VGNC:36995
Mus musculus	XPNPEP2	MGD	MGI:2180001
Rattus norvegicus	XPNPEP2	RGD	RGD:621277
Felis catus	XPNPEP2	VGNC	VGNC:67111
Canis familiaris	XPNPEP2	VGNC	VGNC:48458
Macaca mulatta	XPNPEP2	VGNC	VGNC:78811
Others	XPNPEP2	NCBI

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