XPNPEP2 - X-prolyl aminopeptidase 2 Gene

Also Known as APP2; AEACEI

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7512

About XPNPEP2

Cytogenetic location: Xq26.1 Genomic coordinates (GRCh38): X:129,738,979-129,769,536 (from NCBI)

This gene has 3 transcripts (splice variants), 204 orthologues, 7 paralogues and is associated with 2 phenotypes. Biased expression in small intestine (RPKM 88.3), kidney (RPKM 85.4) and 1 other tissue.

Summary

Aminopeptidase P is a hydrolase specific for N-terminal imido bonds, which are common to several Collagen degradation products, neuropeptides, vasoactive peptides, and cytokines. Structurally, the enzyme is a member of the 'pita bread fold' family and occurs in mammalian tissues in both soluble and GPI-anchored membrane-bound forms. A membrane-bound and soluble form of this enzyme have been identified as products of two separate genes. [provided by RefSeq, Jul 2008]

XPNPEP2 Products (1)

mRNA Protein Name
NM_003399.6 NP_003390.4 xaa-Pro aminopeptidase 2 precursor

Gene Ontology

  • Cellular Component
Cellular Component GO Annotation Evidence References Source
located in extracellular exosome IDA
IDA: Inferred from direct assay
21082674 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

XPNPEP2 Protein Structure

Creatinase_N

Creatinase_N: Creatinase/Prolidase N-terminal domain (54 - 185)

Peptidase_M24

Peptidase_M24: Metallopeptidase family M24 (392 - 575)

  • 0
  • 200
  • 400
  • 600
  • 674 a.a.
Protein Preferred Names Protein Names

xaa-Pro aminopeptidase 2

  • X-Pro aminopeptidase 2

Recombinant XPNPEP2 Proteins

Cat. No. Product Name Accession Purity
HY-P7499 Aminopeptidase P2 Protein, Human (HEK293, His) O43895 (H22-A650) ≥ 80%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Angioedema Induced By Ace Inhibitors

  • AEACEI

  • Angioedema Induced By Ace Inhibitors, Susceptibility To

  • Susceptibility To Angioedema Induced By Ace Inhibitors

  • Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioedema

  • Ace Inhibitor-Related Acquired Angioedema

  • Acei-Related Acquired Angioedema

  • Acquired Angioedema With Normal C1 Inhibitor

  • Acquired Angioedema With Normal C1inh

  • Raas-Blocker-Induced Angioedema

  • Raas-Blocker-Induced Angioneurotic Edema

  • Rae

  • Renin-Angiotensin-Aldosterone System-Blocker-Induced Angioneurotic Edema

  • Ae-Acei

  • Acquired Angioedema
Angioedema

  • Angioneurotic Oedema

  • Quincke'S Edema

  • Angioneurotic Edema

  • Giant Urticaria
Hereditary Angioedema

  • Hereditary Angioneurotic Edema

  • Hereditary Angioedema Type 1

  • Hane

  • Angioedema, Hereditary

  • Hae

  • Angioedemas, Hereditary

  • Deficiency Of C1 Esterase Inhibitor

  • C1 Esterase Inhibitor Deficiency

  • C1 Inhibitor Deficiency

  • Familial Angioneurotic Edema

  • Hereditary Bradykinine-Induced Angioedema

  • Hereditary Non Histamine-Induced Angioedema

  • Hae 1

  • Hae-I

  • Hereditary Angioneurotic Edema Type 1

  • Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor

  • Hereditary Angioedema Types I And Ii

  • Hereditary Angioneurotic Oedema

  • Familial Angioedema

  • Hae - [Hereditary Angioneurotic Oedema]

  • Bannister Disease, Hereditary

  • Quincke Disease Or Oedema

  • Hereditary Quincke Oedema
Pleuropneumonia
Epilepsy, Familial Temporal Lobe, 2

  • Familial Temporal Lobe Epilepsy 2

  • Temporal Epilepsy, Familial

  • ETL2

  • Ftle

  • Epilepsy, Familial Temporal Lobe

  • Familial Temporal Lobe Epilepsy
Nivelon-Nivelon-Mabille Syndrome

  • Chondrodysplasia-Pseudohermaphroditism Syndrome

  • NNMS

  • Chondrodysplasia-Disorder Of Sex Development Syndrome

  • Nivelon Nivelon Mabille Syndrome
Atrophic Rhinitis

  • Rhinitis, Atrophic

  • Ozena

  • Rhinitis Sicca

  • Dry Rhinitis

  • Ozaena
Iminoglycinuria

  • Iminoglycinuria, Digenic

  • IG
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P11814 cTMTP1 / Unkown
HY-P11816 DOTA-cTMTP1 / Unkown
HY-RS15887 XPNPEP2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18585 Xpnpep2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25070 Xpnpep2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus XPNPEP2 VGNC VGNC:36995
Mus musculus XPNPEP2 MGD MGI:2180001
Rattus norvegicus XPNPEP2 RGD RGD:621277
Felis catus XPNPEP2 VGNC VGNC:67111
Canis familiaris XPNPEP2 VGNC VGNC:48458
Macaca mulatta XPNPEP2 VGNC VGNC:78811
Others XPNPEP2 NCBI