2. Antibody-drug Conjugate/ADC Related Others
  3. Radionuclide-Drug Conjugates (RDCs) Drug Derivative
  4. cTMTP1

cTMTP1 (Cyclic TMTP1) is the cyclic form of TMTP1 (HY-P11815). TMTP1 is a tumor-targeting peptide that selectively targets highly metastatic tumor cells. The cTMTP1-based [68Ga]Ga-DOTA-cTMTP1 probe is used for visualization of hepatocellular carcinoma. cTMTP1 can form a 68Ga-DOTA radiotracer that accumulates in highly metastatic cervical cancer cells and is used for microPET tumor visualization. cTMTP1 is applicable to research related to hepatocellular carcinoma and cervical cancer.

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cTMTP1

cTMTP1 Chemical Structure

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cTMTP1 Related Antibodies

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Description

cTMTP1 (Cyclic TMTP1) is the cyclic form of TMTP1 (HY-P11815). TMTP1 is a tumor-targeting peptide that selectively targets highly metastatic tumor cells. The cTMTP1-based [68Ga]Ga-DOTA-cTMTP1 probe is used for visualization of hepatocellular carcinoma. cTMTP1 can form a 68Ga-DOTA radiotracer that accumulates in highly metastatic cervical cancer cells and is used for microPET tumor visualization. cTMTP1 is applicable to research related to hepatocellular carcinoma and cervical cancer[1][2].

IC50 & Target[1]

RDC Peptide

 

In Vitro

cTMTP1-based radiotracer 68Ga-DOTA-TMTP1 (~18.5 KBq/well; 15-120 min; 10 μg cold cyclic TMTP1 pre-incubated for 15 min followed by 60-120 min incubation) exhibits specific, high uptake and retention in highly metastatic HeLa cervical cancer cells compared to low metastatic C-33A cells and normal End1 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

cTMTP1 Related Antibodies
In Vivo

[68Ga]Ga-DOTA-cTMTP1 (5.2 MBq; i.v.; single dose) exhibits sustained tumor retention and high tumor-to-liver ratios (ranging from 2.14 to 2.69) in subcutaneous HCC xenograft mice, demonstrating specific targeting and favorable pharmacokinetics for HCC imaging[1].
[68Ga]Ga-DOTA-cTMTP1 (i.v.; single dose) maintains high tumor-to-liver ratios (ranging from 2.20 to 2.55) and enables sensitive detection of small HCC lesions in transgenic c-Myc liver tumor mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude (male, 5−6 weeks old, ~20 g, subcutaneous xenograft via right forelimb axillary injection of 2×106 SMMC-7721 cells)[1]
Dosage: 5.2 MBq
Administration: i.v.; single dose
Result: Reached tumor uptake of 1.3 %ID/g at 15 min, 1.09 %ID/g at 30 min, and 0.74 %ID/g at 150 min postinjection.
Achieved tumor-to-liver ratios of 2.65 at 30 min, 2.37 at 60 min, 2.14 at 120 min, and 2.69 at 150 min postinjection.
Reached tumor-to-muscle ratio of 11.17 at 150 min postinjection.
Exhibited blood clearance of 1.11 %ID/g at 30 min, 0.48 %ID/g at 60 min, and 0.22 %ID/g at 120 min postinjection.
Reduced tumor uptake to 0.36 %ID/g at 30 min and 0.32 %ID/g at 60 min postinjection upon coinjection of excess linear TMTP1 (p < 0.01).
Molecular Weight

933.07

Formula

C35H60N14O12S2
Sequence

cyclo(Cys-Gly-Asn-Val-Val-Arg-Gln-Gly-Cys) (Disulfide bridge: Cys1-Cys9)
Sequence Shortening

cyclo(CGNVVRQGC) (Disulfide bridge: Cys1-Cys9)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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cTMTP1 Related Classifications

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cTMTP1Cyclic TMTP1cTMTP 1cTMTP-1Cyclic TMTP 1Cyclic TMTP-1Radionuclide-Drug Conjugates (RDCs)Drug DerivativeDrug derivativecervical cancerHCC mouse modelsHeLa cervical cancer cellsC-33A cellshepatocellular carcinomaEnd1 cellstransgenic c-Myc liver tumor micehighly metastatic tumor cellsXPNPEP2subcutaneous HCC xenograft miceInhibitorinhibitorinhibit

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