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ZNF711 - zinc finger protein 711 Gene

Also Known as ZNF4; ZNF5; ZNF6; CMPX1; MRX65; MRX97; XLID97; Zfp711; dJ75N13.1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7552

About ZNF711

Cytogenetic location: Xq21.1 Genomic coordinates (GRCh38): X:85,243,991-85,273,357 (from NCBI)

This gene has 4 transcripts (splice variants), 218 orthologues, 38 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 23.7), brain (RPKM 10.7) and 16 other tissues.

Summary

This gene encodes a Zinc Finger Protein of unknown function. It bears similarity to a Zinc Finger Protein which acts as a transcriptional activator. This gene lies in a region of the X chromosome which has been associated with cognitive disability. [provided by RefSeq, Jul 2008]

ZNF711 Products (9)

mRNA	Protein	Name
NM_001330574.2	NP_001317503.1	zinc finger protein 711 isoform 1
NM_001375431.1	NP_001362360.1	zinc finger protein 711 isoform 1
NM_001375432.1	NP_001362361.1	zinc finger protein 711 isoform 1
NM_001375433.1	NP_001362362.1	zinc finger protein 711 isoform 1
NM_001375434.1	NP_001362363.1	zinc finger protein 711 isoform 2
NM_001375435.1	NP_001362364.1	zinc finger protein 711 isoform 2
NM_001375436.1	NP_001362365.1	zinc finger protein 711 isoform 2
NM_001375437.1	NP_001362366.1	zinc finger protein 711 isoform 2
NM_021998.5	NP_068838.3	zinc finger protein 711 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20346720	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20346720	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20346720	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	31691806	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	20346720	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNF711 Protein Structure

Zfx_Zfy_act

zf-C2H2

zf-H2C2_5

zf-H2C2_2

zf-C2H2_4

zf-H2C2_2

zf-H2C2_5

zf-H2C2_2

zf-C2H2_4

0
200
400
600
761 a.a.

Protein Preferred Names	Protein Names
zinc finger protein 711	dJ75N13.1 (znf6-like)

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, X-Linked 97	XLID97 Mental Retardation, X-Linked 97 Mrx97 Mrx65 Mrxz Mental Retardation, X-Linked 65 Mental Retardation, X-Linked, Type 97 Mental Retardation, X-Linked, Znf711-Related
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability
Non-Syndromic X-Linked Intellectual Disability 97	Mrx65 Mrx97 Mrxz X-Linked Mental Retardation 65 X-Linked Mental Retardation 97
Partington Syndrome	X-Linked Reticulate Pigmentary Disorder PRTS Partington X-Linked Mental Retardation Syndrome Mrxs1 Mrx36 Intellectual Developmental Disorder, X-Linked, Syndromic 1 Partington Disease Pdr Partington-Mulley Syndrome Russell-Silver Syndrome, X-Linked Mental Retardation, X-Linked, Syndromic 1 Mental Retardation, X-Linked, With Dystonic Movements, Ataxia, And Seizures Mental Retardation, X-Linked 36 X-Linked Reticulate Pigmentary Disorder With Systemic Manifestations X-Linked Russell-Silver Syndrome Intelectual Disability-Dystonic Movements-Ataxia-Seizures Syndrome Intellectual Disability, X-Linked, Syndromic 1 Intellectual Disability, X-Linked, With Dystonic Movements, Ataxia, And Seizures Partington X-Linked Intellectual Disability Syndrome X-Linked Intellectual Deficit-Dystonia-Dysarthria X-Linked Mental Retardation With Dystonic Movements, Ataxia, And Seizures Familial Cutaneous Amyloidosis X-Linked Cutaneous Amyloidosis Xlpdr X-Linked Intellectual Disability-Dystonia-Dysarthria Syndrome Pigmentary Disorder, Reticulate, With Systemic Manifestations
Syndromic X-Linked Intellectual Disability Siderius Type	Mrxssd Siderius-Hamel Syndrome Siderius X-Linked Mental Retardation Syndrome
Familial Behcet-Like Autoinflammatory Syndrome	Autoinflammatory Syndrome, Familial, Behcet-Like A20 Haploinsufficiency
Corpus Callosum, Agenesis Of, With Abnormal Genitalia	Proud Syndrome Corpus Callosum Agenesis-Abnormal Genitalia Syndrome Acc With Abnormal Genitalia Proud-Levine-Carpenter Syndrome Microcephaly-Corpus Callosum Agenesis-Abnormal Genitalia Syndrome Corpus Callosum Agenesis With Abnormal Genitalia New X-Linked Syndrome With Seizures, Acquired Micrencephaly, And Agenesis Of The Corpus Callosum Proud Levine Carpenter Syndrome Acc-Abnormal Genitalia Syndrome Agenesis Of The Corpus Callosum, With Abnormal Genitalia ACCAG Micrencephaly-Corpus Callosum Agenesis-Abnormal Genitalia Congenital Neurologic Anomalies
Bleeding Disorder, Platelet-Type, 17	Platelet-Type Bleeding Disorder 17 BDPLT17 Thrombasthenia-Thrombocytopenia, Hereditary Hereditary Thrombasthenia-Thrombocytopenia Autosomal Dominant Macrothrombocytopenia Gfi1b-Related Autosomal Dominant Platelet Disorder Gfi1b-Related Bleeding Disorder, Platelet Type 17
Developmental And Epileptic Encephalopathy 1	Epileptic Encephalopathy, Early Infantile, 1 Infantile Epileptic-Dyskinetic Encephalopathy DEE1 Eiee1 Issx1 Xmesid X-Linked Infantile Spasm Syndrome 1 X-Linked Infantile Spasm Syndrome X-Linked Spasticity-Intellectual Disability-Epilepsy Syndrome Developmental And Epileptic Encephalopathy, 1 Infantile Epileptic Dyskinetic Encephalopathy Infantile Spasm Syndrome, X-Linked 1 West Syndrome, X-Linked Ohtahara Syndrome, X-Linked Early Infantile Epileptic Encephalopathy 1 Early Infantile Epileptic Encephalopathy-1 Issx X-Linked Ohtahara Syndrome X-Linked West Syndrome Infantile Spasm Syndrome X-Linked 1 Myoclonic Epilepsy X-Linked With Intellectual Disability And Spasticity Ohtahara Syndrome X-Linked West Syndrome X-Linked Encephalopathy, Epileptic, Early Infantile, Type 1
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Syndromic Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16169	ZNF711 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZNF711	RGD	RGD:1562768
Mus musculus	ZNF711	MGD	MGI:3045342
Bos taurus	ZNF711	VGNC	VGNC:37337
Canis familiaris	ZNF711	VGNC	VGNC:48806
Others	ZNF711	NCBI