GGCT - gamma-glutamylcyclotransferase Gene

Homo sapiens

Also known as GGC; GCTG; CRF21; C7orf24

Gene ID: 79017 | Gene type: protein coding

About GGCT

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:30,496,621-30,504,829 (from NCBI)

This gene has 8 transcripts (splice variants) and 194 orthologues. Ubiquitous expression in skin (RPKM 24.5), colon (RPKM 21.5) and 25 other tissues.

Summary

The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for Cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

GGCT Products(4)

mRNA	Protein	Name
NM_001199815.2	NP_001186744.1	gamma-glutamylcyclotransferase isoform 2
NM_001199816.2	NP_001186745.1	gamma-glutamylcyclotransferase isoform 3
NM_001199817.2	NP_001186746.1	gamma-glutamylcyclotransferase isoform 4
NM_024051.4	NP_076956.1	gamma-glutamylcyclotransferase isoform 1

GGCT Protein Structure

AIG2_2

0
100
188 a.a.

Protein Preferred Names

Protein Names

gamma-glutamylcyclotransferase

cytochrome c-releasing factor 21

Recombinant GGCT Proteins

Cat. No.	Product Name	Accession	Purity
HY-P70211	GGCT Protein, Human (His)	O75223 (M1-L188)	≥95%

Related Diseases

Diseases

Alias

Glutathione Synthetase Deficiency

5-Oxoprolinuria	Pyroglutamic Aciduria
Pyroglutamicaciduria	Glutathione Synthetase Deficiency With 5-Oxoprolinuria
GSSD	Oxoprolinase Deficiency
5-Oxoprolinemia	Deficiency Of Glutathione Synthase
Deficiency Of Glutathione Synthetase	Pyroglutamic Acidemia
GSS DEFICIENCY	Gluthathione Synthetase Deficiency
5-Oxoprolinase Deficiency

Glutathionuria

Gamma-Glutamyltransferase Deficiency	Ggt Deficiency
Gtg Deficiency	Gamma-Glutamyltranspeptidase Deficiency
Glutathioninuria	Gamma-Glutamyl Transpeptidase Deficiency
Gamma-Glutamyl Transferase Deficiency	Ggt1 Deficiency
GLUTH

Spinocerebellar Ataxia 10

Spinocerebellar Ataxia Type 10	SCA10
Spinocerebellar Ataxia-10	Ataxia, Spinocerebellar, Type 10

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05397	GGCT Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	GGCT	VGNC	VGNC:108409
Felis catus	GGCT	VGNC	VGNC:102585
Canis familiaris	GGCT	VGNC	VGNC:99775
Bos taurus	GGCT	VGNC	VGNC:107225
Rattus norvegicus	GGCT	RGD	RGD:1304876
Mus musculus	GGCT	MGD	MGI:95700
Others	GGCT	NCBI