GGCT - gamma-glutamylcyclotransferase Gene

Also Known as GGC; GCTG; CRF21; C7orf24

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79017

About GGCT

Cytogenetic location: 7p14.3 Genomic coordinates (GRCh38): 7:30,496,621-30,504,829 (from NCBI)

This gene has 8 transcripts (splice variants) and 194 orthologues. Ubiquitous expression in skin (RPKM 24.5), colon (RPKM 21.5) and 25 other tissues.

Summary

The protein encoded by this gene catalyzes the formation of 5-oxoproline from gamma-glutamyl dipeptides, the penultimate step in glutathione catabolism, and may play a critical role in glutathione homeostasis. The encoded protein may also play a role in cell proliferation, and the expression of this gene is a potential marker for Cancer. Pseudogenes of this gene are located on the long arm of chromosome 5 and the short arm of chromosomes 2 and 20. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2010]

GGCT Products (4)

mRNA Protein Name
NM_001199815.2 NP_001186744.1 gamma-glutamylcyclotransferase isoform 2
NM_001199816.2 NP_001186745.1 gamma-glutamylcyclotransferase isoform 3
NM_001199817.2 NP_001186746.1 gamma-glutamylcyclotransferase isoform 4
NM_024051.4 NP_076956.1 gamma-glutamylcyclotransferase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables gamma-glutamylcyclotransferase activity IDA
IDA: Inferred from direct assay
18515354 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
17932939 GOA
Biological Process GO Annotation Evidence References Source
involved in release of cytochrome c from mitochondria IMP
IMP: Inferred from mutant phenotype
16765912 GOA
Cellular Component GO Annotation Evidence References Source
located in cytosol IDA
IDA: Inferred from direct assay
16765912 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GGCT Protein Structure

AIG2_2

AIG2_2: AIG2-like family (78 - 160)

  • 0
  • 100
  • 188 a.a.
Protein Preferred Names Protein Names

gamma-glutamylcyclotransferase

  • cytochrome c-releasing factor 21

Recombinant GGCT Proteins

Cat. No. Product Name Accession Purity
HY-P70211 GGCT Protein, Human (His) O75223-1 (M1-L188) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Glutathione Synthetase Deficiency

  • 5-Oxoprolinuria

  • Pyroglutamic Aciduria

  • Pyroglutamicaciduria

  • Glutathione Synthetase Deficiency With 5-Oxoprolinuria

  • GSSD

  • Oxoprolinase Deficiency

  • 5-Oxoprolinemia

  • Deficiency Of Glutathione Synthase

  • Deficiency Of Glutathione Synthetase

  • Pyroglutamic Acidemia

  • GSS DEFICIENCY

  • Gluthathione Synthetase Deficiency

  • 5-Oxoprolinase Deficiency
Glutathionuria

  • Gamma-Glutamyltransferase Deficiency

  • Ggt Deficiency

  • Gtg Deficiency

  • Gamma-Glutamyltranspeptidase Deficiency

  • Glutathioninuria

  • Gamma-Glutamyl Transpeptidase Deficiency

  • Gamma-Glutamyl Transferase Deficiency

  • Ggt1 Deficiency

  • GLUTH
Spinocerebellar Ataxia 10

  • Spinocerebellar Ataxia Type 10

  • SCA10

  • Spinocerebellar Ataxia-10

  • Ataxia, Spinocerebellar, Type 10
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-171030 Pro-GA Activator 97.86% Unkown
HY-RS05397 GGCT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19604 Ggct Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26100 Ggct Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta GGCT VGNC VGNC:108409
Felis catus GGCT VGNC VGNC:102585
Canis familiaris GGCT VGNC VGNC:99775
Bos taurus GGCT VGNC VGNC:107225
Rattus norvegicus GGCT RGD RGD:1304876
Mus musculus GGCT MGD MGI:95700
Others GGCT NCBI