APOO - apolipoprotein O Gene

Also Known as MIC26; Mic23; My025; FAM121B; MICOS26

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79135

About APOO

Cytogenetic location: Xp22.11 Genomic coordinates (GRCh38): X:23,833,353-23,907,938 (from NCBI)

This gene has 9 transcripts (splice variants), 293 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 9.7), brain (RPKM 7.6) and 25 other tissues.

Summary

This gene is a member of the Apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009]

APOO Products (1)

mRNA Protein Name
NM_024122.5 NP_077027.1 MICOS complex subunit MIC26 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25764979 GOA
Biological Process GO Annotation Evidence References Source
involved in cristae formation IMP
IMP: Inferred from mutant phenotype
25764979 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi membrane IDA
IDA: Inferred from direct assay
25764979 GOA
part of MICOS complex IDA
IDA: Inferred from direct assay
25764979 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
25764979 GOA
located in extracellular region IDA
IDA: Inferred from direct assay
25764979 GOA
located in mitochondrial inner membrane IDA
IDA: Inferred from direct assay
25764979 GOA
located in mitochondrion IDA
IDA: Inferred from direct assay
24743151 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

APOO Protein Structure

ApoO

ApoO: Apolipoprotein O (27 - 177)

  • 0
  • 100
  • 198 a.a.
Protein Preferred Names Protein Names

MICOS complex subunit MIC26

  • MICOS complex subunit MIC23

APOO Antibodies

Cat. No. Product Name Application Reactivity
HY-P84764 ApoO Antibody (YA4461) WB, IHC-P, ELISA Human, Mouse
HY-P84764A ApoO Antibody (YA4461)(PBS only) WB, IHC-P, ELISA Human, Mouse

Related Diseases

Diseases Alias
Lactic Acidosis

  • Acidosis, Lactic

  • Acidosis Lactic
Combined Oxidative Phosphorylation Deficiency 37

  • COXPD37
Barth Syndrome

  • 3-Methylglutaconic Aciduria Type 2

  • BTHS

  • Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria

  • Mga Type Ii

  • Mga2

  • Mgca2

  • Mga Type 2

  • 3-Methylglutaconic Aciduria Type Ii

  • 3-Methylglutaconic Aciduria, Type Ii

  • Mga, Type Ii

  • 3-Methylglutaconicaciduria Type 2

  • 3-Methylglutaconicaciduria Type Ii

  • Taz Defect

  • 3 Methylglutaconic Aciduria, Type Ii

  • Dnajc19 Defect

  • Cardioskeletal Myopathy-Neutropenia Syndrome

  • X-Linked Cardioskeletal Myopathy And Neutropenia

  • 3-Alpha-Methylglutaconic Aciduria Type 2

  • Agm2

  • Cardioskeletal Myopathy-Neutropenia

  • Invm

  • Left Ventricular Non-Compaction Isolated X-Linked

  • Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked

  • Agammaglobulinemia 2, Autosomal Recessive
Sengers Syndrome

  • Mitochondrial Dna Depletion Syndrome 10

  • Cardiomyopathy And Cataract

  • Cataract And Cardiomyopathy

  • MTDPS10

  • Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome

  • Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10

  • Senger Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00861 APOO Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19576 Apoo Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26073 Apoo Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus APOO MGD MGI:1915566
Bos taurus APOO VGNC VGNC:26035
Macaca mulatta APOO VGNC VGNC:103788
Rattus norvegicus APOO RGD RGD:1565289
Felis catus APOO VGNC VGNC:97354
Others APOO NCBI