APOO - apolipoprotein O Gene

Homo sapiens

Also known as MIC26; Mic23; My025; FAM121B; MICOS26

Gene ID: 79135 | Gene type: protein coding

About APOO

Cytogenetic location: Xp22.11 Genomic coordinates (GRCh38): X:23,833,353-23,907,938 (from NCBI)

This gene has 9 transcripts (splice variants), 293 orthologues and 1 paralogue. Ubiquitous expression in heart (RPKM 9.7), brain (RPKM 7.6) and 25 other tissues.

Summary

This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009]

APOO Products(1)

mRNA	Protein	Name
NM_024122.5	NP_077027.1	MICOS complex subunit MIC26 precursor

APOO Protein Structure

ApoO

0
100
198 a.a.

Protein Preferred Names

Protein Names

MICOS complex subunit MIC26

MICOS complex subunit MIC23

Related Diseases

Diseases

Alias

Lactic Acidosis

Acidosis, Lactic

Acidosis Lactic

Combined Oxidative Phosphorylation Deficiency 37

COXPD37

Barth Syndrome

3-Methylglutaconic Aciduria Type 2	BTHS
Cardioskeletal Myopathy With Neutropenia And Abnormal Mitochondria	Mga Type Ii
Mga2	Mgca2
Mga Type 2	3-Methylglutaconic Aciduria Type Ii
3-Methylglutaconic Aciduria, Type Ii	Mga, Type Ii
3-Methylglutaconicaciduria Type 2	3-Methylglutaconicaciduria Type Ii
Taz Defect	3 Methylglutaconic Aciduria, Type Ii
Dnajc19 Defect	Cardioskeletal Myopathy-Neutropenia Syndrome
X-Linked Cardioskeletal Myopathy And Neutropenia	3-Alpha-Methylglutaconic Aciduria Type 2
Agm2	Cardioskeletal Myopathy-Neutropenia
Invm	Left Ventricular Non-Compaction Isolated X-Linked
Non-Compaction Of Left Ventricular Myocardium Isolated X-Linked	Agammaglobulinemia 2, Autosomal Recessive

Sengers Syndrome

Mitochondrial Dna Depletion Syndrome 10	Cardiomyopathy And Cataract
Cataract And Cardiomyopathy	MTDPS10
Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome	Cardiomyopathic Mitochondrial Dna Depletion Syndrome 10
Senger Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00861	APOO Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	APOO	MGD	MGI:1915566
Bos taurus	APOO	VGNC	VGNC:26035
Macaca mulatta	APOO	VGNC	VGNC:103788
Rattus norvegicus	APOO	RGD	RGD:1565289
Felis catus	APOO	VGNC	VGNC:97354