ApoO Antibody (YA4461)
(Synonyms: MYO25; FAM121B; MGC4825)ApoO Antibody (YA4461) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ApoO.
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Host:
Mouse
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Isotype:
IgG1
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Application:
WB, IHC-P, ELISA
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Reactivity :
Human, Mouse
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Formulation:
Supplied in ascitic fluid containing 0.03% sodium azide.
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Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
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IHC-P
IHC-P: Immunohistochemistry-Paraffin
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ELISA
ELISA: Enzyme Linked Immunosorbent Assay
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|---|---|---|---|
| Dilution Ratio | 1:500-1:2000 | 1:200-1:1000 | 1:10000 |
Product Details
ApoO Antibody (YA4461) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to ApoO.
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Host Mouse
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Clonality Monoclonal
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Species ReactivityHuman, Mouse
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Observed Molecular WeightObserved band size: 22 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
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Calculated Molecular Weight Predicted band size: 22 kDa
Purified recombinant fragment of ApoO aa 26-198.
affinity purified.
Non-conjugated
Unmodified
IgG1
Product Properties
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Appearance
Liquid
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Formulation
Supplied in ascitic fluid containing 0.03% sodium azide.
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Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
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선적
Shipping with blue ice.
Background
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Function
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a crucial role in crista junction formation and mitochondrial function (PubMed:25764979). Can promote cardiac lipotoxicity by enhancing mitochondrial respiration and fatty acid metabolism in cardiac myoblasts (PubMed:24743151). Promotes cholesterol efflux from macrophage cells. Detected in HDL, LDL and VLDL. Secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL (PubMed:16956892)
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Subcellular Localization
Mitochondrion inner membrane; Single-pass membrane protein; Secreted; Mitochondrion; Golgi apparatus membrane; Endoplasmic reticulum membrane
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Expression
Tissue_specificity:It was expressed in all tissues tested. Its expression was upregulated in diabetic hearts. -
Isoforms & Post-Translational Modification
Q9BUR5 has 2 isomers: Q9BUR5-1: 22285 Da (predicted); Q9BUR5-2: 20199 Da (predicted).
O-glycosylation; glycosaminoglycan of chondroitin-sulfate type -
Subunit
Component of the mitochondrial contact site and cristae organizing system (MICOS) complex, composed of at least MICOS10/MIC10, CHCHD3/MIC19, CHCHD6/MIC25, APOOL/MIC27, IMMT/MIC60, APOO/MIC23/MIC26 and MICOS13/MIC13.
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SwissProt ID
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Synonyms
MYO25; FAM121B; MGC4825
각종 서류
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