ZFHX4 - zinc finger homeobox 4 Gene

Also Known as ZFH4; ZHF4

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 79776

About ZFHX4

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:76,681,247-76,867,281 (from NCBI)

This gene has 14 transcripts (splice variants), 207 orthologues, 20 paralogues and is associated with 3 phenotypes. Broad expression in testis (RPKM 2.1), adrenal (RPKM 2.1) and 16 other tissues.

Summary

Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

ZFHX4 Products (2)

mRNA Protein Name
NM_001410934.1 NP_001397863.1 zinc finger homeobox protein 4 isoform 2
NM_024721.5 NP_078997.4 zinc finger homeobox protein 4 isoform 1

ZFHX4 Protein Structure

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (645 - 667)

zf-met

zf-met: Zinc-finger of C2H2 type (699 - 723)

zf-C2H2

zf-C2H2: Zinc finger, C2H2 type (1593 - 1617)

Homeobox

Homeobox: Homeobox domain (2130 - 2186)

Homeobox

Homeobox: Homeobox domain (2227 - 2283)

Homeobox

Homeobox: Homeobox domain (2606 - 2662)

Homeobox

Homeobox: Homeobox domain (2930 - 2986)

  • 0
  • 600
  • 1200
  • 1800
  • 2400
  • 3000
  • 3616 a.a.
Protein Preferred Names Protein Names

zinc finger homeobox protein 4

  • zinc-finger homeodomain protein 4

Related Diseases

Diseases Alias
Ptosis, Hereditary Congenital 1

  • Ptosis, Hereditary Congenital, 1

  • PTOS1

  • Ptosis, Hereditary Congenital, Type 1
Congenital Ptosis

  • Congenital Blepharoptosis

  • Congenital Eyelid Ptosis
Marcus Gunn Phenomenon

  • Jaw-Winking Syndrome

  • Marcus-Gunn Syndrome

  • Jaw-Winking

  • Maxillopalpebral Synkinesis

  • Abnormal Innervation Syndrome Of Eyelid

  • Jaw-Blinking

  • Pterygoid-Levator Synkinesis

  • Familial Marcus Gunn Phenomenon

  • Marcus Gunn Syndrome

  • Mandibulo-Palpebral Synkinesis-Ptosis Syndrome

  • Marcus-Gunn Phenomenon
Ptosis

  • Blepharoptosis

  • Drooping Eyelid

  • Droopy Eyelid

  • Ptosis Of Eyelid

  • Paralysis Of Levator Palpebrae Superioris
Chromosome 8q21.11 Deletion Syndrome

  • 8q21.11 Microdeletion Syndrome

  • Del(8)(Q21.11)

  • Deletion 8q21.11

  • Monosomy 8q21.11
Peters-Plus Syndrome

  • Krause-Kivlin Syndrome

  • Peters Plus Syndrome

  • Peters Anomaly

  • Irido-Corneo-Trabecular Dysgenesis

  • PTRPLS

  • Peters Anomaly With Short-Limb Dwarfism

  • Peters Anomaly-Short Limb Dwarfism Syndrome

  • Peters Anomaly With Short Limb Dwarfism

  • Peters Congenital Glaucoma

  • Krause-Van Schooneveld-Kivlin Syndrome

  • Peters' Plus Syndrome

  • Peters'-Plus Syndrome

  • Anomaly Peters
Duane Retraction Syndrome

  • Stilling-Turk-Duane Syndrome

  • Duane'S Syndrome

  • Duane Syndrome

  • Isolated Duane Retraction Syndrome

  • Co-Contractive Retraction Syndrome

  • Duane Anomaly, Isolated

  • Ocular Retraction Syndrome

  • Drs

  • Durs
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16037 ZFHX4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ZFHX4 VGNC VGNC:67229
Canis familiaris ZFHX4 VGNC VGNC:48608
Rattus norvegicus ZFHX4 RGD RGD:1563022
Macaca mulatta ZFHX4 VGNC VGNC:79902
Mus musculus ZFHX4 MGD MGI:2137668
Bos taurus ZFHX4 VGNC VGNC:37158