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CLMP - CXADR like membrane protein Gene

Also Known as ACAM; ASAM; CSBM; CSBS

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79827

About CLMP

Cytogenetic location: 11q24.1 Genomic coordinates (GRCh38): 11:123,069,872-123,195,248 (from NCBI)

This gene has 4 transcripts (splice variants), 397 orthologues, 14 paralogues and is associated with 3 phenotypes. Broad expression in fat (RPKM 45.1), endometrium (RPKM 20.9) and 17 other tissues.

Summary

This gene encodes a type I transmembrane protein that is localized to junctional complexes between endothelial and epithelial cells and may have a role in cell-cell adhesion. Expression of this gene in white adipose tissue is implicated in adipocyte maturation and development of obesity. This gene is also essential for normal intestinal development and mutations in the gene are associated with congenital short bowel syndrome. [provided by RefSeq, Aug 2015]

CLMP Products (1)

mRNA	Protein	Name
NM_024769.5	NP_079045.1	CXADR-like membrane protein precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in digestive tract development	IMP IMP: Inferred from mutant phenotype	22155368	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in bicellular tight junction	IDA IDA: Inferred from direct assay	22155368	GOA
located in cytoplasmic microtubule	IDA IDA: Inferred from direct assay	23264731	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLMP Protein Structure

V-set

Ig_2

0
100
200
300
373 a.a.

Protein Preferred Names	Protein Names
CXADR-like membrane protein	CAR-like membrane protein

CLMP Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CLMP	Q9H6B4	LCN2	Homo sapiens	P80188	Y2H Array	32296183
Intra	CLMP	Q9H6B4	LCN2	Homo sapiens	P80188	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CLMP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7609	ASAM/CLMP Protein, Human (HEK293, His)	Q9H6B4 (T19-M233)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Congenital Short Bowel Syndrome	CSBS Congenital Short Bowel Congenital Short Bowel And Malrotation Syndrome Csbm Bowel, Short, Syndrome, Congenital Intestinal Pseudo-Obstruction
Intestinal Pseudo-Obstruction	Chronic Intestinal Pseudoobstruction Chronic Intestinal Pseudo-Obstruction Cipo Neuronal Intestinal Dysplasia Hollow Visceral Myopathy Familial Visceral Neuropathy Paralytic Ileus Intestinal Pseudoobstruction Chronic Idiopathic Intestinal Pseudo-Obstruction Ciip Congenital Short Bowel Syndrome Enteric Neuropathy Familial Visceral Myopathy Ipo Pseudo-Obstruction Of Intestine Pseudointestinal Obstruction Syndrome Pseudoobstructive Syndrome Congenital Idiopathic Intestinal Pseudoobstruction Visceral Myopathy, Familial
Short Bowel Syndrome	Short Gut Syndrome Acquired Short Bowel Syndrome Secondary Short Bowel Syndrome Short Bowel Nos
Interstitial Myocarditis
Testicular Thecoma
Cataract 4, Multiple Types	Cataract 4 Multiple Types CTRCT4 Cca3 Pcc Aculeiform Cataract Cataract 4, Multiple Types, With Or Without Microcornea Cataract, Crystalline Aculeiform Caca Cataract, Congenital, Cerulean Type, 3 Congenital Cataract Cerulean Type 3 Cataract Congenital Dominant Non Nuclear Ccp Cataract, Nonnuclear Polymorphic Congenital Cataract, Punctate, Progressive Juvenile-Onset Cataract 4 Multiple Types With Or Without Microcornea Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract Cataract, Polymorphic Congenital Congenital Cataract Blue Dot Type 3 Congenital Non-Nuclear Polymorphic Cataract Crystalline Aculeiform Cataract Punctate, Progressive Juvenile-Onset, Cataract Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant
Trichothiodystrophy	Ttd Amish Brittle Hair Syndrome Bids Syndrome Brittle Hair-Intellectual Impairment-Decreased Fertility-Short Stature Syndrome Ibids Pibids Trichothiodystrophy Syndromes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02821	CLMP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19312	Clmp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25803	Clmp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	CLMP	VGNC	VGNC:71328
Felis catus	CLMP	VGNC	VGNC:60967
Mus musculus	CLMP	MGD	MGI:1918816
Bos taurus	CLMP	VGNC	VGNC:50091
Rattus norvegicus	CLMP	RGD	RGD:708569
Others	CLMP	NCBI