LPCAT1 - lysophosphatidylcholine acyltransferase 1 Gene

Also Known as AYTL2; lpcat; AGPAT9; LPLAT8; PFAAP3; AGPAT10; LPCAT-1; lysoPAFAT

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 79888

About LPCAT1

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:1,461,427-1,523,960 (from NCBI)

This gene has 6 transcripts (splice variants), 1 gene allele, 249 orthologues and 4 paralogues. Broad expression in lung (RPKM 73.0), spleen (RPKM 32.6) and 18 other tissues.

Summary

This gene encodes a member of the 1-acyl-sn-glycerol-3-phosphate Acyltransferase family of proteins. The encoded enzyme plays a role in phospholipid metabolism, specifically in the conversion of lysophosphatidylcholine to phosphatidylcholine in the presence of acyl-CoA. This process is important in the synthesis of lung surfactant and platelet-activating factor (PAF). Elevated expression of this gene may contribute to the progression of oral squamous cell, prostate, breast, and Other human cancers. [provided by RefSeq, Sep 2016]

LPCAT1 Products (1)

mRNA	Protein	Name
NM_024830.5	NP_079106.3	lysophosphatidylcholine acyltransferase 1

LPCAT1 Protein Structure

Acyltransferase

EF-hand_6

EF-hand_8

0
100
200
300
400
500
534 a.a.

Protein Preferred Names	Protein Names
lysophosphatidylcholine acyltransferase 1	1-acylglycerol-3-phosphate O-acyltransferase

LPCAT1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81530	LPCAT1 Antibody (YA1275)	IHC-P	Human
HY-P81530A	LPCAT1 Antibody (YA1275)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Epithelioid Trophoblastic Tumor	Trophoblastic Tumor, Epithelioid
Newborn Respiratory Distress Syndrome	Hyaline Membrane Disease Respiratory Distress Syndrome Of Newborn Neonatal Respiratory Distress Hmd - Hyaline Membrane Disease Neonatal Respiratory Distress Syndrome Pulmonary Hyaline Membrane Disease Pulmonary Hypoperfusion Syndrome Of Newborn Respiratory Distress Syndrome, Newborn Respiratory Distress Syndrome Cardiorespiratory Distress Syndrome Of Newborn Distress Respiratory Syndrome Newborn Idiopathic Respiratory Distress Syndrome Idiopathic Respiratory Distress Syndrome Of Newborn Newborn Idiopathic Respiratory Distress Syndrome Respiratory Distress Syndrome In Newborn Rds - [Respiratory Distress Syndrome] Of Newborn Newborn Cardiorespiratory Distress Syndrome
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W140439	1-Oleoyl-sn-glycero-3-phosphocholine		99.58%	Unkown
HY-112825	TSI-01	Inhibitor	98.52%	Unkown
HY-RS07764	LPCAT1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18199	Lpcat1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24675	Lpcat1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LPCAT1	RGD	RGD:1311599
Mus musculus	LPCAT1	MGD	MGI:2384812
Macaca mulatta	LPCAT1	VGNC	VGNC:74361
Felis catus	LPCAT1	VGNC	VGNC:63264
Bos taurus	LPCAT1	VGNC	VGNC:30961
Canis familiaris	LPCAT1	VGNC	VGNC:42748
Others	LPCAT1	NCBI