YIPF5 - Yip1 domain family member 5 Gene

Also Known as MEDS2; SB140; SMAP5; YIP1A; SMAP-5; FinGER5

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 81555

About YIPF5

Cytogenetic location: 5q31.3 Genomic coordinates (GRCh38): 5:144,158,162-144,170,659 (from NCBI)

This gene has 6 transcripts (splice variants), 214 orthologues, 3 paralogues and is associated with 2 phenotypes. Ubiquitous expression in placenta (RPKM 14.2), thyroid (RPKM 12.3) and 25 other tissues.

Summary

Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; regulation of ER to Golgi vesicle-mediated transport; and vesicle fusion with Golgi apparatus. Located in Golgi apparatus; endoplasmic reticulum; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

YIPF5 Products (3)

mRNA Protein Name
NM_001024947.4 NP_001020118.1 protein YIPF5 isoform a
NM_001271732.2 NP_001258661.1 protein YIPF5 isoform b
NM_030799.9 NP_110426.4 protein YIPF5 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
23736259 GOA
Biological Process GO Annotation Evidence References Source
involved in insulin processing IMP
IMP: Inferred from mutant phenotype
33164986 GOA
involved in regulation of ER to Golgi vesicle-mediated transport IMP
IMP: Inferred from mutant phenotype
33164986 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

YIPF5 Protein Structure

Yip1

Yip1: Yip1 domain (97 - 228)

  • 0
  • 100
  • 200
  • 257 a.a.
Protein Preferred Names Protein Names

protein YIPF5

  • YIP1 family member 5

YIPF5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
YIPF5 Q969M3 YIF1A Homo sapiens O95070
Y2H Prey Pooling
32296183
Intra
YIPF5 Q969M3 YIF1A Homo sapiens O95070
Anti Tag CoIP
26496610
Intra
YIPF5 Q969M3 YIF1A Homo sapiens O95070
Y2H Array
32296183
Intra
YIPF5 Q969M3 YIF1A Homo sapiens O95070
Anti Tag CoIP
35271311
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Microcephaly, Epilepsy, And Diabetes Syndrome 2

  • MEDS2
Primary Microcephaly-Epilepsy-Permanent Neonatal Diabetes Syndrome
Spontaneous Ocular Nystagmus

  • Visual Deprivation Nystagmus

  • Ocular Nystagmus

  • Searching Eye Movements

  • Nystagmus, Pathologic
Microcephaly

  • Microencephaly

  • Microcephalus

  • Microcephalic

  • Nanocephaly

  • Congenital Microcephaly

  • Brain Hypoplasia

  • Brain Nondevelopment

  • Cephalic Hypoplasia

  • Undeveloped Cerebrum

  • Undeveloped Brain

  • Micrencephalon

  • Micrencephaly
Spinal Muscular Atrophy, Type Ii

  • SMA2

  • Sma Ii

  • Muscular Atrophy, Spinal, Intermediate Type

  • Muscular Atrophy, Spinal, Infantile Chronic Form

  • Intermediate Spinal Muscular Atrophy

  • Spinal Muscular Atrophy Type Ii

  • Spinal Muscular Atrophy-2

  • Spinal Muscular Atrophy 2

  • Spinal Muscular Atrophy Type 2

  • Dubowitz Disease

  • Proximal Spinal Muscular Atrophy Type 2

  • Sma Type 2

  • Sma Type Ii

  • Sma-Ii

  • Spinal Muscular Atrophy Infantile Chronic Form

  • Spinal Muscular Atrophy Intermediate Type

  • Spinal Muscular Atrophies Of Childhood

  • Atrophy, Muscular, Spinal, Type Ii

  • Muscular Atrophy, Spinal, Type Ii
Epiphyseal Dysplasia, Multiple, With Early-Onset Diabetes Mellitus

  • Wolcott-Rallison Syndrome

  • Med-Iddm Syndrome

  • Iddm-Med Syndrome

  • Wolcott Rallison Syndrome

  • WRS

  • Epiphyseal Dysplasia Multiple With Early-Onset Diabetes Mellitus

  • Early-Onset Diabetes Mellitus With Multiple Epiphyseal Dysplasia

  • Multiple Epiphyseal Dysplasia With Early-Onset Diabetes Mellitus
Permanent Neonatal Diabetes Mellitus

  • Pndm

  • Permanent Diabetes Mellitus Of Infancy

  • Pdmi

  • Neonatal Diabetes Mellitus, Permanent
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15925 YIPF5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta YIPF5 VGNC VGNC:79461
Felis catus YIPF5 VGNC VGNC:67143
Canis familiaris YIPF5 VGNC VGNC:48491
Rattus norvegicus YIPF5 RGD RGD:1359165
Bos taurus YIPF5 VGNC VGNC:37027
Mus musculus YIPF5 MGD MGI:1914430
Others YIPF5 NCBI