KATNAL2 - katanin catalytic subunit A1 like 2 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83473

About KATNAL2

Cytogenetic location: 18q21.1 Genomic coordinates (GRCh38): 18:46,917,594-47,102,243 (from NCBI)

This gene has 25 transcripts (splice variants), 202 orthologues and 9 paralogues. Broad expression in testis (RPKM 2.3), thyroid (RPKM 1.9) and 23 other tissues.

Summary

Predicted to enable microtubule-severing ATPase activity. Predicted to be involved in cytoplasmic microtubule organization. Located in cytoplasm; microtubule; and spindle pole. [provided by Alliance of Genome Resources, Apr 2022]

KATNAL2 Products (14)

mRNA Protein Name
NM_001353899.1 NP_001340828.1 katanin p60 ATPase-containing subunit A-like 2 isoform 1
NM_001353900.1 NP_001340829.1 katanin p60 ATPase-containing subunit A-like 2 isoform 2
NM_001353901.1 NP_001340830.1 katanin p60 ATPase-containing subunit A-like 2 isoform 3
NM_001353902.1 NP_001340831.1 katanin p60 ATPase-containing subunit A-like 2 isoform 4
NM_001353903.1 NP_001340832.1 katanin p60 ATPase-containing subunit A-like 2 isoform 6
NM_001353904.1 NP_001340833.1 katanin p60 ATPase-containing subunit A-like 2 isoform 7
NM_001353905.1 NP_001340834.1 katanin p60 ATPase-containing subunit A-like 2 isoform 8
NM_001353906.1 NP_001340835.1 katanin p60 ATPase-containing subunit A-like 2 isoform 8
NM_001353907.1 NP_001340836.1 katanin p60 ATPase-containing subunit A-like 2 isoform 9
NM_001353908.1 NP_001340837.1 katanin p60 ATPase-containing subunit A-like 2 isoform 10
NM_001353909.1 NP_001340838.1 katanin p60 ATPase-containing subunit A-like 2 isoform 11
NM_001367621.1 NP_001354550.1 katanin p60 ATPase-containing subunit A-like 2 isoform 13
NM_001387690.1 NP_001374619.1 katanin p60 ATPase-containing subunit A-like 2 isoform 13
NM_031303.3 NP_112593.2 katanin p60 ATPase-containing subunit A-like 2 isoform 5

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25910212 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
26929214 GOA
located in microtubule IDA
IDA: Inferred from direct assay
26929214 GOA
located in spindle IDA
IDA: Inferred from direct assay
26929214 GOA
located in spindle pole IDA
IDA: Inferred from direct assay
26929214 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KATNAL2 Protein Structure

LisH

LisH: LisH (27 - 53)

AAA

AAA: ATPase family associated with various cellular activities (AAA) (290 - 421)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 538 a.a.
Protein Preferred Names Protein Names

katanin p60 ATPase-containing subunit A-like 2

  • katanin catalytic subunit A like 2

KATNAL2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KATNAL2 Q8IYT4 LNX1 Homo sapiens Q8TBB1
Y2H Array
32296183
Intra
KATNAL2 Q8IYT4 LNX1 Homo sapiens Q8TBB1
Y2H Prey Pooling
32296183
Intra
KATNAL2 Q8IYT4 LNX1 Homo sapiens Q8TBB1
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Fraser Syndrome 2

  • FRASRS2
Ceroid Lipofuscinosis, Neuronal, 8

  • Neuronal Ceroid Lipofuscinosis 8

  • CLN8

  • Cln8 Disease

  • Epilepsy Mental Deterioration Finnish Type

  • Northern Epilepsy

  • Cln8 Disease, Epmr

  • Cln8 Disease, Northern Epilepsy Variant

  • Cln8 Disease, Late Infantile

  • Ceroid Lipofuscinosis Neuronal 8

  • Ncl, Northern Epilepsy Variant

  • Neuronal Ceroid Lipofuscinosis, Northern Epilepsy Variant

  • Progressive Epilepsy - Intellectual Disability, Finnish Type

  • Progressive Epilepsy-Intellectual Disability Syndrome, Finnish Type

  • Turkish Variant Late Infantile Ncl

  • Ceroid Lipofuscinosis, Neuronal 8

  • Lipofuscinosis, Ceroid, Neuronal, Type 8

  • Northern Epilepsy Syndrome
Bainbridge-Ropers Syndrome

  • BRPS

  • Severe Feeding Difficulties-Failure To Thrive-Microcephaly Due To Asxl3 Deficiency Syndrome

  • Asxl3-Related Disorder
Meningioma, Familial

  • Meningioma

  • Familial Meningioma

  • Meningioma, Familial, Susceptibility To

  • Meningeal Neoplasm

  • Meningeal Neoplasms

  • Meningiomas

  • Meningioma, Nf2-Related, Somatic

  • Meningioma, Sis-Related

  • Meningothelial Cell Tumor

  • Neoplasm Of The Meninges

  • Primary Meningeal Tumor

  • Familial Multiple Meningioma

  • MNGMA

  • Meningioma, Benign, No Icd-O Subtype

  • Intracranial Meningioma

  • Meningothelial Cell Neoplasm

  • Supratentorial Meningioma

  • Primary Neoplasm Of Spinal Meninges

  • Benign Intracranial Meningioma

  • Benign Meningioma

  • Meningeal Tumours

  • Meningeal Sarcoma Of Unspecified Site

  • Meningothelial Sarcoma Of Unspecified Site
Coffin-Siris Syndrome 1

  • Coffin-Siris Syndrome

  • Fifth Digit Syndrome

  • Css

  • CSS1

  • Mrd12

  • Mental Retardation, Autosomal Dominant 12

  • Hhid

  • Dwarfism-Onychodysplasia

  • Hypertrichosis, Hyperkeratosis, Mental Retardation, And Distinctive Facial Features

  • Autosomal Dominant Mental Retardation 12

  • Short Stature-Onychodysplasia.

  • Intellectual Disability With Absent Fifth Fingernail And Terminal Phalanx

  • Mental Retardation With Hypoplastic Fifth Fingernails And Toenails

  • Short Stature-Onychodysplasia

  • Coffin-Siris Syndrome, Type 1

  • Mental Retardation, Autosomal Dominant, Type 12
Autism

  • Autistic Disorder

  • Autism Susceptibility 1

  • Childhood Autism

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Kanner'S Syndrome

  • Autistic
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07086 KATNAL2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta KATNAL2 VGNC VGNC:73904
Bos taurus KATNAL2 VGNC VGNC:30407
Mus musculus KATNAL2 MGD MGI:1924234
Rattus norvegicus KATNAL2 RGD RGD:1564708
Felis catus KATNAL2 VGNC VGNC:63029
Canis familiaris KATNAL2 VGNC VGNC:42218
Others KATNAL2 NCBI