ARHGAP24 - Rho GTPase activating protein 24 Gene

Also Known as p73; FILGAP; RCGAP72; RC-GAP72; p73RhoGAP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83478

About ARHGAP24

Cytogenetic location: 4q21.23-q21.3 Genomic coordinates (GRCh38): 4:85,475,150-86,002,666 (from NCBI)

This gene has 12 transcripts (splice variants), 201 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 13.8), thyroid (RPKM 4.3) and 20 other tissues.

Summary

This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

ARHGAP24 Products (5)

mRNA	Protein	Name
NM_001025616.3	NP_001020787.2	rho GTPase-activating protein 24 isoform 1
NM_001042669.2	NP_001036134.1	rho GTPase-activating protein 24 isoform 3
NM_001287805.2	NP_001274734.1	rho GTPase-activating protein 24 isoform 4
NM_001346093.2	NP_001333022.1	rho GTPase-activating protein 24 isoform 5
NM_031305.3	NP_112595.2	rho GTPase-activating protein 24 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16862148	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP24 Protein Structure

PH

RhoGAP

0
200
400
600
748 a.a.

Protein Preferred Names	Protein Names
rho GTPase-activating protein 24	RAC1- and CDC42-specific GTPase-activating protein of 72 kDa

ARHGAP24 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ARHGAP24	Q8N264	FLNA	Homo sapiens	P21333	Anti Bait CoIP	16862148
Intra	ARHGAP24	Q8N264	FLNA	Homo sapiens	P21333	Y2H	16862148
Intra	ARHGAP24	Q8N264	FLNA	Homo sapiens	P21333	Pull Down	16862148
Intra	ARHGAP24	Q8N264	FLNA	Homo sapiens	P21333	IF	16862148
Intra	ARHGAP24	Q8N264	HTT	Homo sapiens	P42858	Y2H	17500595

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Genetic Steroid-Resistant Nephrotic Syndrome	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Genetic Srns Hereditary Steroid-Resistant Nephrotic Syndrome Familial Idiopathic Nephrotic Syndrome Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive Srn1
Tarp Syndrome	TARPS Pierre Robin Syndrome With Congenital Heart Malformation And Clubfoot Pierre Robin Sequence-Congenital Heart Defect-Talipes Syndrome Pierre Robin Syndrome-Congenital Heart Defect-Talipes Syndrome Talipes Equinovarus-Atrial Septal Defect-Robin Sequence-Persistence Of The Left Superior Vena Cava Syndrome Talipes Equinovarus, Atrial Septal Defect, Robin Sequence, And Persistence Of Left Superior Vena Cava Pierre Robin Sequence - Congenital Heart Defect - Talipes Pierre Robin Syndrome - Congenital Heart Defect - Talipes Talipes Equinovarus - Atrial Septal Defect - Robin Sequence - Persistence Of The Left Superior Vena Cava Talipes Equinovarus Atrial Septal Defect Robin Sequence And Persistence Of Left Superior Vena Cava
Melnick-Needles Syndrome	MNS Melnick-Needles Osteodysplasty Osteodysplasty Of Melnick And Needles Osteochondrodysplasias
Frasier Syndrome	FS
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Alport Syndrome	Hereditary Nephritis Alport Syndrome, X-Linked Hemorrhagic Hereditary Nephritis Congenital Hereditary Hematuria Hemorrhagic Familial Nephritis Familial Nephritis Thin Basement Membrane Disease Thin Basement Membrane Nephropathy Hematuria-Nephropathy-Deafness Syndrome Hematuric Hereditary Nephritis Hereditary Familial Congenital Hemorrhagic Nephritis Hereditary Hematuria Syndrome Hereditary Interstitial Pyelonephritis Alport Deafness-Nephropathy Alport Hearing Loss-Nephropathy Alports Syndrome Nephritis, Hereditary
Periventricular Nodular Heterotopia	Periventricular Heterotopia Pvnh Familial Nodular Heterotopia Heterotopia, Periventricular Periventricular Heterotopia, X-Linked
Focal Segmental Glomerulosclerosis	Familial Idiopathic Steroid-Resistant Nephrotic Syndrome Focal Glomerulosclerosis Fsgs Segmental Glomerulosclerosis Glomerulosclerosis, Focal Segmental Fgs Focal Glomerular Sclerosis Familial Idiopathic Nephrotic Syndrome Focal Sclerosis With Hyalinosis Glomerulosclerosis, Focal Glomerulosclerosis Focal Glomerulosclerosis, Segmental, Focal Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00924	ARHGAP24 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARHGAP24	VGNC	VGNC:69904
Mus musculus	ARHGAP24	MGD	MGI:1922647
Rattus norvegicus	ARHGAP24	RGD	RGD:1306669
Canis familiaris	ARHGAP24	VGNC	VGNC:38053
Bos taurus	ARHGAP24	VGNC	VGNC:26082
Felis catus	ARHGAP24	VGNC	VGNC:59881
Others	ARHGAP24	NCBI