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DNAL1 - dynein axonemal light chain 1 Gene

Also Known as LC1; CILD16; C14orf168

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 83544

About DNAL1

Cytogenetic location: 14q24.3 Genomic coordinates (GRCh38): 14:73,644,986-73,703,732 (from NCBI)

This gene has 9 transcripts (splice variants), 196 orthologues and is associated with 2 phenotypes. Broad expression in thyroid (RPKM 3.1), brain (RPKM 3.1) and 25 other tissues.

Summary

This gene encodes an axonemal dynein light chain which functions as a component of the outer dynein arms complex. This complex acts as the molecular motor that provides the force to move cilia in an ATP-dependent manner. The encoded protein is expressed in tissues with motile cilia or flagella and may be involved in the movement of sperm flagella. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2011]

DNAL1 Products (2)

mRNA	Protein	Name
NM_001201366.2	NP_001188295.1	dynein axonemal light chain 1 isoform 2
NM_031427.4	NP_113615.2	dynein axonemal light chain 1 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables alpha-tubulin binding	IMP IMP: Inferred from mutant phenotype	21496787	GOA
enables dynein heavy chain binding	IDA IDA: Inferred from direct assay	15845866	GOA
enables dynein heavy chain binding	IMP IMP: Inferred from mutant phenotype	21496787	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	29601588	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in outer dynein arm assembly	IMP IMP: Inferred from mutant phenotype	21496787	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DNAL1 Protein Structure

LRR_9

0
100
190 a.a.

Protein Preferred Names	Protein Names
dynein axonemal light chain 1

DNAL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DNAL1	Q4LDG9	LRRC40	Homo sapiens	Q9H9A6	Y2H Prey Pooling	32296183
Intra	DNAL1	Q4LDG9	LRRC40	Homo sapiens	Q9H9A6	Validated Y2H	32296183
Intra	DNAL1	Q4LDG9	LRRC40	Homo sapiens	Q9H9A6	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Ciliary Dyskinesia, Primary, 16	CILD16 Primary Ciliary Dyskinesia 16 Primary Ciliary Dyskinesia 16 With Or Without Situs Inversus Ciliary Dyskinesia, Primary, 16, With Or Without Situs Inversus Ics16 Immotile Cilia Syndrome 16 Dyskinesia, Ciliary, Primary, 16
Primary Ciliary Dyskinesia	Immotile Cilia Syndrome Kartagener Syndrome Dextrocardia Bronchiectasis And Sinusitis Pcd Ciliary Motility Disorders Ciliary Motility Disorder Immotile Ciliary Syndrome Ciliary Dyskinesia Primary Ics Polynesian Bronchiectasis Dextrocardia-Bronchiectasis-Sinusitis Syndrome Immotile Cilia Syndrome, Kartagener Type Primary Ciliary Dyskinesia And Situs Inversus Primary Ciliary Dyskinesia, Kartagener Type Siewert Syndrome Dyskinesia, Ciliary, Primary
Amelogenesis Imperfecta, Type Ib	AI1B Aih2 Amelogenesis Imperfecta Type 1b Amelogenesis Imperfecta Type Ib Hereditary Localized Enamel Hypoplasia Amelogenesis Imperfecta - Hypoplastic Autosomal Dominant - Local Amelogenesis Imperfecta, Hypoplastic Local, Autosomal Dominant Enamel Hypoplasia, Hereditary Localized Autosomal Dominant Hypoplastic Local Amelogenesis Imperfecta Amelogenesis Imperfecta 1b Amelogenesis Imperfecta Hypoplastic 2 Amelogenesis Imperfecta Hypoplastic Local Autosomal Dominant
Amelogenesis Imperfecta, Type Ie	Aih1 Amelogenesis Imperfecta Type 1e AI1E Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 1 Amelogenesis Imperfecta, Hypomaturation Type, With Snow-Capped Teeth Enamel Hypoplasia, X-Linked Amelogenesis Imperfecta Type Ie Amelogenesis Imperfecta Hypoplastic/Hypomaturation X-Linked 1 Enamel Hypoplasia X-Linked Amelogenesis Imperfecta, X-Linked 1 Amelogenesis Imperfecta, Type 1e Amelogenesis Imperfecta Hypomaturationtype With Snow-Capped Teeth X-Linked Amelogenesis Imperfecta 1 X-Linked Amelogenesis Imperfecta Hypoplastic/Hypomaturation 1 X-Linked Enamel Hypoplasia Amelogenesis Imperfecta X-Linked 1 Amelogenesis Imperfecta 1e Amelogenesis Imperfecta, Hypoplastic/Hypomaturation Type 1e Amelogenesis Imperfecta Hypomaturation Type With Snow-Capped Teeth Xai X-Linked Amelogenesis Imperfecta Amelogenesis Imperfecta, Hypoplastic/Hypomaturation, X-Linked 2
Kartagener Syndrome	Kartagener'S Syndrome
Situs Inversus	Situs Inversus Viscerum Laterality Sequence Complete Transposition Siv
Paranoid Personality Disorder
Autoimmune Cholangitis	Autoimmune Cholangiopathy
Drug-Induced Hepatitis	Drug-Induced Chronic Hepatitis Chemical And Drug Induced Liver Injury, Chronic Hepatitis, Drug-Induced Hepatitis, Chronic, Drug-Induced
Sclerosing Cholangitis	Fibrosing Cholangitis Cholangitis, Sclerosing Primary Sclerosing Cholangitis
Cholangitis, Primary Sclerosing	Primary Sclerosing Cholangitis PSC Sclerosing Cholangitis Cholangitis, Sclerosing Cholangitis Primary Sclerosing Psc - [Primary Sclerosing Cholangitis]
Amelogenesis Imperfecta	Ai Congenital Enamel Hypoplasia Al - [Amelogenesis Imperfecta]
Primary Biliary Cholangitis	Primary Biliary Cirrhosis Biliary Liver Cirrhosis Chronic Nonsuppurative Destructive Cholangitis Familial Primary Biliary Cirrhosis Pbc Hanot Syndrome Cholestatic Cirrhosis Biliary Cirrhosis Primary Liver Cirrhosis, Biliary Hanot'S Cirrhosis Biliary Cirrhosis Pericholangiolic Biliary Cirrhosis Tannhauser-Magendantz Syndrome Hanot-Rossle Syndrome Hypertrophic Cirrhosis Todd Cirrhosis Hanot Cirrhosis Charcot Cirrhosis Mahon-Tannhauser Syndrome Toxic Cirrhosis Hypertrophic Biliary Cirrhosis Monolobular Cirrhosis Unilobar Cirrhosis Xanthomatous Biliary Cirrhosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03891	DNAL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DNAL1	VGNC	VGNC:71885
Canis familiaris	DNAL1	VGNC	VGNC:50523
Mus musculus	DNAL1	MGD	MGI:1921462
Bos taurus	DNAL1	VGNC	VGNC:55111
Rattus norvegicus	DNAL1	RGD	RGD:1591349
Felis catus	DNAL1	VGNC	VGNC:61549