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ZRANB3 - zinc finger RANBP2-type containing 3 Gene

Also Known as AH2; 4933425L19Rik

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84083

About ZRANB3

Cytogenetic location: 2q21.3 Genomic coordinates (GRCh38): 2:135,196,969-135,531,218 (from NCBI)

This gene has 11 transcripts (splice variants), 197 orthologues and 30 paralogues. Broad expression in testis (RPKM 1.8), thyroid (RPKM 0.8) and 24 other tissues.

Summary

Enables ATP-dependent DNA/DNA annealing activity; K63-linked polyubiquitin modification-dependent protein binding activity; and endodeoxyribonuclease activity. Involved in several processes, including DNA metabolic process; DNA rewinding; and negative regulation of DNA recombination. Located in nuclear replication fork and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ZRANB3 Products (3)

mRNA	Protein	Name
NM_001286568.2	NP_001273497.1	DNA annealing helicase and endonuclease ZRANB3 isoform 2
NM_001286569.1	NP_001273498.1	DNA annealing helicase and endonuclease ZRANB3 isoform 3
NM_032143.4	NP_115519.2	DNA annealing helicase and endonuclease ZRANB3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP-dependent DNA/DNA annealing activity	IDA IDA: Inferred from direct assay	21078962	GOA
enables DNA endonuclease activity	IDA IDA: Inferred from direct assay	22759634	GOA
NOT enables DNA helicase activity	IDA IDA: Inferred from direct assay	21078962	GOA
enables K63-linked polyubiquitin modification-dependent protein binding	IDA IDA: Inferred from direct assay	22704558	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22704558	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in DNA damage response	IDA IDA: Inferred from direct assay	22704558	GOA
involved in DNA repair	IDA IDA: Inferred from direct assay	22759634	GOA
involved in DNA rewinding	IDA IDA: Inferred from direct assay	21078962	GOA
involved in negative regulation of DNA recombination	IDA IDA: Inferred from direct assay	22704558	GOA
involved in replication fork processing	IDA IDA: Inferred from direct assay	22704558	GOA
involved in replication fork reversal	IDA IDA: Inferred from direct assay	22704558	GOA
involved in response to UV	IDA IDA: Inferred from direct assay	22704558	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nuclear replication fork	IDA IDA: Inferred from direct assay	22704558	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZRANB3 Protein Structure

SNF2_N

Helicase_C

zf-RanBP

HNH

0
200
400
600
800
1000
1079 a.a.

Protein Preferred Names	Protein Names
DNA annealing helicase and endonuclease ZRANB3	annealing helicase 2

ZRANB3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZRANB3	Q5FWF4	PCNA	Homo sapiens	P12004	Confocal	22759634
Intra	ZRANB3	Q5FWF4	PCNA	Homo sapiens	P12004	Anti Tag CoIP	22759634
Intra	ZRANB3	Q5FWF4	PCNA	Homo sapiens	P12004	Pull Down	22759634

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Schimke Immunoosseous Dysplasia	Schimke Immuno-Osseous Dysplasia SIOD Immunoosseous Dysplasia, Schimke Type Schimke Syndrome Immunoosseous Dysplasia Schimke Type Spondyloepiphyseal Dysplasia - Nephrotic Syndrome Spondyloepiphyseal Dysplasia Nephrotic Syndrome Spondyloepiphyseal Dysplasia-Nephrotic Syndrome
Amelogenesis Imperfecta, Type If	Amelogenesis Imperfecta Type 1f AI1F Amelogenesis Imperfecta, Hypoplastic Type If Amelogenesis Imperfecta Type If Amelogenesis Imperfecta Hypoplastic Type If Amelogenesis Imperfecta 1f
Chronic Inducible Urticaria
Hypotrichosis 7	Woolly Hair, Autosomal Recessive 2, With Or Without Hypotrichosis HYPT7 Hypotrichosis, Localized, Autosomal Recessive 2 Lah2 Ah Total Hypotrichosis, Mari Type Wh/Ht Hypotrichosis, Autosomal Recessive Hypotrichosis, Total, Mari Type Woolly Hair, Autosomal Recessive 2 With Or Without Hypotrichosis Total Mari Type Hypotrichosis Alopecia Universalis Congenita, Mari Type Mari Type Alopecia Universalis Congenita Autosomal Recessive Hypotrichosis Autosomal Recessive Localized Hypotrichosis Autosomal Recessive Woolly Hair With Or Without Hypotrichosis Htl Hypotrichoses Hypotrichosis Lah Alopecia Universalis Congenita Mari Type Hypotrichosis Autosomal Recessive Hypotrichosis Localized Autosomal Recessive 2 Total Hypotrichosis Mari Type Woolly Hair Autosomal Recessive 2 ARWH2 Woolly Hair Autosomal Recessive 2 With Or Without Hypotrichosis
Chronic Intestinal Vascular Insufficiency	Chronic Mesenteric Ischemia Cmi - Chronic Mesenteric Ischaemia
Cerebellar Ataxia Type 9	Sca9
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16195	ZRANB3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ZRANB3	MGD	MGI:1918362
Macaca mulatta	ZRANB3	VGNC	VGNC:79486
Felis catus	ZRANB3	VGNC	VGNC:80416
Canis familiaris	ZRANB3	VGNC	VGNC:48849
Rattus norvegicus	ZRANB3	RGD	RGD:1564952
Bos taurus	ZRANB3	VGNC	VGNC:37373
Others	ZRANB3	NCBI