USP42 - ubiquitin specific peptidase 42 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84132

About USP42

This gene has 7 transcripts (splice variants), 255 orthologues and 71 paralogues. Broad expression in testis (RPKM 9.2), bone marrow (RPKM 4.1) and 24 other tissues.

Summary

Enables thiol-dependent Deubiquitinase. Involved in protein deubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

USP42 Products (3)

mRNA Protein Name
NM_001365764.1 NP_001352693.1 ubiquitin carboxyl-terminal hydrolase 42 isoform 1
NM_001389650.1 NP_001376579.1 ubiquitin carboxyl-terminal hydrolase 42 isoform 3
NM_032172.3 NP_115548.1 ubiquitin carboxyl-terminal hydrolase 42 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables cysteine-type deubiquitinase activity IDA
IDA: Inferred from direct assay
14715245 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22085928 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP42 Protein Structure

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (111 - 409)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1316 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 42

  • deubiquitinating enzyme 42

USP42 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
USP42 Q9H9J4 TP53 Homo sapiens P04637
Anti Bait CoIP
22085928
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Deafness, Autosomal Dominant 21

  • DFNA21

  • Autosomal Dominant Nonsyndromic Deafness 21

  • Autosomal Dominant Deafness 21

  • Deafness, Autosomal Dominant, 21
Myelodysplastic Syndrome

  • Myelodysplastic Syndromes

  • Myelodysplasia

  • MDS

  • Myelodysplastic Syndrome Included

  • Myelodysplastic Syndrome, Susceptibility To, Included

  • Myelodysplastic Syndrome, Somatic

  • Myelodysplastic Syndrome, Susceptibility To
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15553 USP42 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22902 Usp42 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29416 Usp42 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus USP42 VGNC VGNC:50065
Macaca mulatta USP42 VGNC VGNC:79225
Canis familiaris USP42 VGNC VGNC:54087
Mus musculus USP42 MGD MGI:1924050
Rattus norvegicus USP42 RGD RGD:1305231
Felis catus USP42 VGNC VGNC:107828
Others USP42 NCBI