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ZNRF3 - zinc and ring finger 3 Gene

Also Known as RNF203; BK747E2.3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84133

About ZNRF3

Cytogenetic location: 22q12.1 Genomic coordinates (GRCh38): 22:28,883,572-29,057,488 (from NCBI)

This gene has 3 transcripts (splice variants), 202 orthologues, 1 paralogue and is associated with 81 phenotypes. Ubiquitous expression in kidney (RPKM 4.8), brain (RPKM 4.7) and 24 other tissues.

Summary

Enables Frizzled binding activity and ubiquitin-protein transferase activity. Involved in cellular protein metabolic process and negative regulation of Wnt signaling pathway. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

ZNRF3 Products (2)

mRNA	Protein	Name
NM_001206998.2	NP_001193927.1	E3 ubiquitin-protein ligase ZNRF3 isoform 1 precursor
NM_032173.4	NP_115549.2	E3 ubiquitin-protein ligase ZNRF3 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables frizzled binding	IPI IPI: Inferred from physical interaction	22575959	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22575959	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	22575959	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Wnt receptor catabolic process	IMP IMP: Inferred from mutant phenotype	22575959	GOA
involved in negative regulation of canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	22575959	GOA
involved in negative regulation of non-canonical Wnt signaling pathway	IMP IMP: Inferred from mutant phenotype	22575959	GOA
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	22575959	GOA
involved in ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	22575959	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	22575959	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZNRF3 Protein Structure

zf-RING_2

0
200
400
600
800
936 a.a.

Protein Preferred Names	Protein Names
E3 ubiquitin-protein ligase ZNRF3	CTA-292E10.6

ZNRF3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	ZNRF3	Q9ULT6	RSPO1	Homo sapiens	Q2MKA7	SPR	24165923
Intra	ZNRF3	Q9ULT6	RSPO1	Homo sapiens	Q2MKA7	Pull Down	22575959
Intra	ZNRF3	Q9ULT6	RSPO1	Homo sapiens	Q2MKA7	Anti Tag CoIP	22575959
Intra	ZNRF3	Q9ULT6	LGR4	Homo sapiens	Q9BXB1	Anti Tag CoIP	22575959
Intra	ZNRF3	Q9ULT6	FZD6	Homo sapiens	O60353	Anti Bait CoIP	22575959
Intra	ZNRF3	Q9ULT6	LRP6	Homo sapiens	O75581	Anti Bait CoIP	22575959

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ZNRF3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78750	ZNRF3 Protein, Human (HEK293, His)	Q9ULT6-1 (K56-M219)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Adrenal Carcinoma	Adrenal Cancer Adrenal Gland Cancer Malignant Neoplasm Of Adrenal Gland Adrenal Gland Neoplasms Carcinoma Of The Adrenal Gland Adrenal Neoplasm Malignant Adrenal Tumor Neoplasm Of Adrenal Gland Tumor Of The Adrenal Gland Adrenal Gland Neoplasm Adrenocortical Carcinoma Adrenal Gland Malignancy Suprarenal Cancer Malignant Neoplasm Of Suprarenal Gland Malignant Neoplasm Of Adrenal Gland, Unspecified Malignant Tumour Of Adrenal Gland Suprarenal Gland Cancer Primary Malignant Neoplasm Of Adrenal Gland
Tetraamelia Syndrome	Tetra-Amelia Syndrome Tetraamelia-Multiple Malformations Syndrome Tetra-Amelia Tetra-Amelia, Autosomal Recessive Tetraamelia, Autosomal Recessive Total Amelia Zimmer Phocomelia Tetams Zimmer Taub Sova Syndrome
Uterine Corpus Endometrial Carcinoma
Osteoblastoma
Adrenal Cortex Disease	Adrenal Cortex Diseases
Skin Melanoma	Cutaneous Melanoma Malignant Ear Melanoma Malignant Lip Melanoma Malignant Lower Limb Melanoma Malignant Melanoma Of Ear And/Or External Auricular Canal Malignant Melanoma Of Skin Of Lower Limb Malignant Melanoma Of Skin Of Trunk Except Scrotum Malignant Melanoma Of Skin Of Upper Limb Malignant Neck Melanoma Malignant Scalp Melanoma Malignant Trunk Melanoma Malignant Upper Limb Melanoma Melanoma, Cutaneous Malignant Melanoma Malignant Melanoma Of Skin Melanoma Nos Malignant Mole, Meaning Melanoma Of Unspecified Site Melanoma Of Unspecified Site Cutaneous Malignant Melanoma Mm - [Malignant Melanoma]
Adrenal Cortical Carcinoma	Adrenocortical Carcinoma Adrenal Cortex Carcinoma Carcinoma Of The Adrenal Cortex Acc Adrenocortical Cancer Carcinoma Adrenocortical
Carney Complex Variant	Carney Complex Carney Syndrome Carney Complex, Type 1 Lamb Syndrome Name Syndrome Myxoma-Spotty Pigmentation-Endocrine Overactivity Syndrome Carney Complex - Trismus - Pseudocamptodactyly Syndrome Carney Complex, Type 2 Car Cnc1 Carney Myxoma-Endocrine Complex Myxoma - Spotty Pigmentation - Endocrine Overactivity Myxoma, Spotty Pigmentation, And Endocrine Overactivity Lamb - Lentigines, Atrial Myxoma, Mucocutaneous Myoma, Blue Nevus Syndrome Name - Nevi, Atrial Myxoma, Skin Myxoma, Ephelides Syndrome Carney Complex-Trismus-Pseudocamptodactyly Syndrome CACOV
Li-Fraumeni Syndrome	Sarcoma Family Syndrome Of Li And Fraumeni Sbla Syndrome LFS Li-Fraumeni Familiar Cancer Susceptibility Syndrome Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome Lfs1 Li Fraumeni Syndrome Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome Lfl Sbla Syndrome Li-Fraumeni-Like Syndrome Li-Fraumeni Syndrome 1
Beckwith-Wiedemann Syndrome	Wiedemann-Beckwith Syndrome BWS Exomphalos-Macroglossia-Gigantism Syndrome Emg Syndrome Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation Emg Abnormality Wbs Exomphalos Macroglossia Gigantism Syndrome Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation Macroglossia Exomphalos Gigantism

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10810	QPH-FR	Inhibitor	99.54%	Unkown
HY-RS16185	ZNRF3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17716	Znrf3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24181	Znrf3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	ZNRF3	VGNC	VGNC:67372
Macaca mulatta	ZNRF3	VGNC	VGNC:79114
Canis familiaris	ZNRF3	VGNC	VGNC:48840
Mus musculus	ZNRF3	MGD	MGI:3039616
Rattus norvegicus	ZNRF3	RGD	RGD:1593771
Bos taurus	ZNRF3	VGNC	VGNC:55766
Others	ZNRF3	NCBI